PMID- 2918936
OWN - NLM
STAT- MEDLINE
DCOM- 19890405
LR  - 20061115
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 338
IP  - 6211
DP  - 1989 Mar 9
TI  - Preferential mutation of paternally derived RB gene as the initial event in 
      sporadic osteosarcoma.
PG  - 156-8
AB  - Successive loss of function of both alleles of the retinoblastoma susceptibility 
      gene (RB) on human chromosome 13 seems to be critical in the development of 
      retinoblastoma and osteosarcoma. In cases where the tumour is familial and 
      susceptibility is inherited, a mutation in one of the alleles is carried in the 
      germline. We have recently shown that cytogenetically visible germline mutations 
      are usually in the paternally derived gene. Such a bias would not be expected for 
      sporadic (non-familial) tumours, where both mutations occur in somatic tissue, 
      but there has been some indication of a bias towards initial somatic mutation in 
      the paternally derived gene on chromosome 11 in sporadic Wilms tumour. We have 
      now examined 13 sporadic osteosarcomas and find evidence which indicates that in 
      12 cases the initial mutation was in the paternal gene, suggesting the 
      involvement of germinal imprinting in producing the differential susceptibility 
      of the two genes to mutation.
FAU - Toguchida, J
AU  - Toguchida J
AD  - Radiation Biology Center, Faculty of Medicine, Kyoto University, Japan.
FAU - Ishizaki, K
AU  - Ishizaki K
FAU - Sasaki, M S
AU  - Sasaki MS
FAU - Nakamura, Y
AU  - Nakamura Y
FAU - Ikenaga, M
AU  - Ikenaga M
FAU - Kato, M
AU  - Kato M
FAU - Sugimot, M
AU  - Sugimot M
FAU - Kotoura, Y
AU  - Kotoura Y
FAU - Yamamuro, T
AU  - Yamamuro T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
MH  - Blotting, Southern
MH  - *Chromosomes, Human, Pair 13
MH  - Humans
MH  - Mutation
MH  - Osteosarcoma/*genetics
MH  - Retinoblastoma/*genetics
EDAT- 1989/03/09 00:00
MHDA- 1989/03/09 00:01
CRDT- 1989/03/09 00:00
PHST- 1989/03/09 00:00 [pubmed]
PHST- 1989/03/09 00:01 [medline]
PHST- 1989/03/09 00:00 [entrez]
AID - 10.1038/338156a0 [doi]
PST - ppublish
SO  - Nature. 1989 Mar 9;338(6211):156-8. doi: 10.1038/338156a0.