PMID- 29191432
OWN - NLM
STAT- MEDLINE
DCOM- 20190620
LR  - 20190620
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 32
IP  - 2
DP  - 2018 Feb
TI  - Cereal fiber, fruit fiber, and type 2 diabetes: Explaining the paradox.
PG  - 240-245
LID - S1056-8727(17)30812-7 [pii]
LID - 10.1016/j.jdiacomp.2017.11.002 [doi]
AB  - While the relationship between dietary fiber and type 2 diabetes mellitus (T2DM) 
      has been much studied, the evidence about its role in the prevention and control 
      of this condition has been conflicting. We critically evaluate prospective cohort 
      studies and randomized controlled trials (RCTs) that examined 
      insoluble/nonviscous/cereal fiber and soluble/viscous/fruit fiber in relation to 
      risk of T2DM. Taken as a whole this evidence indicates that, in the quantities 
      typically eaten, cereal fiber is protective against T2DM while fruit fiber gives 
      little protection. We argue that the protective action of cereal fiber may be 
      explained by the modulating effects of gut microbiota through mechanisms such as: 
      1) improving glucose tolerance via energy metabolism pathways (colonic 
      fermentation and generation of short-chain fatty acids); 2) reducing 
      inflammation; and 3) altering the immune response. By gaining more knowledge of 
      specific host and gut microbial functional pathways involved in T2DM development 
      and the potential role of cereal fiber, appropriate disease prevention and 
      intervention strategies may be developed.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Davison, Karen M
AU  - Davison KM
AD  - Health Science Program, Department of Biology, Kwantlen Polytechnic University, 
      Surrey, British Columbia, Canada. Electronic address: karend@athabascau.ca.
FAU - Temple, Norman J
AU  - Temple NJ
AD  - Centre for Science, Athabasca University, Athabasca, Alberta T9S 3A3, Canada. 
      Electronic address: normant@athabascau.ca.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171110
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Dietary Fiber)
SB  - IM
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/complications/diet therapy/*epidemiology/microbiology
MH  - *Dietary Fiber/administration & dosage/adverse effects
MH  - *Edible Grain/adverse effects/physiology
MH  - Feeding Behavior/*physiology
MH  - *Fruit/adverse effects/chemistry
MH  - Gastrointestinal Microbiome/physiology
MH  - Humans
MH  - Risk Factors
OTO - NOTNLM
OT  - Cereal fiber
OT  - Diabetes
OT  - Dietary fiber
OT  - Microbiome
OT  - Type 2 diabetes
EDAT- 2017/12/02 06:00
MHDA- 2019/06/21 06:00
CRDT- 2017/12/02 06:00
PHST- 2017/06/10 00:00 [received]
PHST- 2017/10/10 00:00 [revised]
PHST- 2017/11/03 00:00 [accepted]
PHST- 2017/12/02 06:00 [pubmed]
PHST- 2019/06/21 06:00 [medline]
PHST- 2017/12/02 06:00 [entrez]
AID - S1056-8727(17)30812-7 [pii]
AID - 10.1016/j.jdiacomp.2017.11.002 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2018 Feb;32(2):240-245. doi: 
      10.1016/j.jdiacomp.2017.11.002. Epub 2017 Nov 10.