PMID- 29191565
OWN - NLM
STAT- MEDLINE
DCOM- 20190501
LR  - 20190501
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 121
IP  - 3
DP  - 2018 Feb 1
TI  - Magnetic Resonance Imaging Correlates of Left Bundle Branch Disease in Patients 
      With Nonischemic Cardiomyopathy.
PG  - 370-376
LID - S0002-9149(17)31681-8 [pii]
LID - 10.1016/j.amjcard.2017.10.024 [doi]
AB  - The pathologic correlates of intraventricular conduction delays in patients with 
      nonischemic cardiomyopathy (NIC) have been scarcely investigated. We assessed 
      left ventricular (LV) structural, functional, and tissue abnormalities associated 
      with intraventricular conduction left bundle disease (LBD), including left 
      anterior hemiblock or complete left bundle branch block, in a cohort of patients 
      with NIC submitted to cardiovascular magnetic resonance. Twelve-lead 
      electrocardiogram and cardiovascular magnetic resonance were performed in 196 
      consecutive patients with NIC. The presence and extent of myocardial fibrosis was 
      evaluated with late gadolinium enhancement (LGE) technique. Compared with normal 
      intraventricular conduction patients, those with LBD were older (66 vs 59 years, 
      p = 0.001), had greater LV volumes (p = 0.035 for end-diastolic and p = 0.009 for 
      end-systolic volume) and mass (p = 0.034), and showed lower LV ejection fraction 
      (33% vs 40%, p = 0.008). LGE was observed more commonly in LBD than in normal 
      intraventricular conduction patients and was more often located in the 
      ventricular septum (p < 0.001). On multivariate analysis, septal LGE was 
      independently associated with a higher likelihood of LBD (odds ratio 6.1, 95% 
      confidence interval 2.9 to 12.7, p < 0.001), even after correction for LV 
      volumes, mass, and ejection fraction. In conclusion, in NIC, the presence of LBD 
      is associated with worse LV remodeling and dysfunction than normal 
      intraventricular conduction. Septal fibrosis yielded a 6-fold greater likelihood 
      of LBD, independently of the degree of LV dilatation and systolic dysfunction.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Grigoratos, Chrysanthos
AU  - Grigoratos C
AD  - Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy; Institute of Life 
      Sciences, Scuola Superiore Sant'Anna, Pisa, Italy. Electronic address: 
      cgrigoratos@ftgm.it.
FAU - Liga, Riccardo
AU  - Liga R
AD  - Cardiac, Thoracic and Vascular Department, University of Pisa, Pisa, Italy.
FAU - Bennati, Elena
AU  - Bennati E
AD  - Department of Cardiovascular Diseases, University of Siena, Siena, Italy.
FAU - Barison, Andrea
AU  - Barison A
AD  - Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy; Institute of Life 
      Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
FAU - Todiere, Giancarlo
AU  - Todiere G
AD  - Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy.
FAU - Aquaro, Giovanni Donato
AU  - Aquaro GD
AD  - Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy.
FAU - Dell'Omodarme, Matteo
AU  - Dell'Omodarme M
AD  - Department of Physics, University of Pisa, Pisa, Italy.
FAU - Emdin, Michele
AU  - Emdin M
AD  - Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy; Institute of Life 
      Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
FAU - Masci, Pier Giorgio
AU  - Masci PG
AD  - Centre for cardiac MRI/Department of Cardiology, University Hospital of Lausanne, 
      Lausanne, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20171106
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Contrast Media)
SB  - IM
MH  - Aged
MH  - Bundle-Branch Block/*diagnostic imaging/physiopathology
MH  - Cardiomyopathies/*diagnostic imaging/physiopathology
MH  - Contrast Media
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/physiopathology
EDAT- 2017/12/02 06:00
MHDA- 2019/05/02 06:00
CRDT- 2017/12/02 06:00
PHST- 2017/07/17 00:00 [received]
PHST- 2017/10/13 00:00 [revised]
PHST- 2017/10/13 00:00 [accepted]
PHST- 2017/12/02 06:00 [pubmed]
PHST- 2019/05/02 06:00 [medline]
PHST- 2017/12/02 06:00 [entrez]
AID - S0002-9149(17)31681-8 [pii]
AID - 10.1016/j.amjcard.2017.10.024 [doi]
PST - ppublish
SO  - Am J Cardiol. 2018 Feb 1;121(3):370-376. doi: 10.1016/j.amjcard.2017.10.024. Epub 
      2017 Nov 6.