PMID- 29192418
OWN - NLM
STAT- MEDLINE
DCOM- 20180712
LR  - 20180816
IS  - 0017-0011 (Print)
IS  - 0017-0011 (Linking)
VI  - 88
IP  - 10
DP  - 2017
TI  - Novel biomarkers of overactive bladder syndrome.
PG  - 568-573
LID - 10.5603/GP.a2017.0102 [doi]
AB  - The social aspect of overactive bladder syndrome (OAB) and the lack of objective 
      diagnostic methods for this syndrome have spurred research into its potential 
      biomarkers which can constitute useful diagnostic tools, while also allowing the 
      evaluation of the intensity of clinical symptoms and the efficacy of implemented 
      pharmacotherapy in OAB patients. Due to the complex etiopathogenesis of this 
      syndrome, the researchers are seeking biomarkers connected with inflammation or 
      nerve growth. The aim of this review was to analyse the latest literature data 
      regarding potential biomarkers in OAB. The most promising opportunities are 
      connected with the diagnostic use of the nerve growth factor (NGF), the brain 
      derived neurotrophic factor (BDNF), C-reactive protein (CRP), prostaglandins and 
      cytokines. Despite the most promising results to date having been obtained with 
      regards to neurotrophic factors, it seems that, at the moment, none of these 
      meets the criteria for becoming an isolated OAB marker. It is also suggested that 
      the combined use of several biomarkers will facilitate obtaining the appropriate 
      level of specificity and selectivity to allow their use in clinical practice.
FAU - Wrobel, Andrzej Franciszek
AU  - Wrobel AF
AD  - Second Department of Gynecology, Medical University of Lublin,, Jaczewskiego 8, 
      PL 20-090 Lublin, Poland, 20-090, Lublin, Poland. wrobelandrzej@yahoo.com.
FAU - Kluz, Tomasz
AU  - Kluz T
FAU - Surkont, Grzegorz
AU  - Surkont G
FAU - Wlazlak, Edyta
AU  - Wlazlak E
FAU - Skorupski, Pawel
AU  - Skorupski P
FAU - Filipczak, Aleksandra
AU  - Filipczak A
FAU - Rechberger, Tomasz
AU  - Rechberger T
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Poland
TA  - Ginekol Pol
JT  - Ginekologia polska
JID - 0374641
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NGF protein, human)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Biomarkers/*urine
MH  - Brain-Derived Neurotrophic Factor/urine
MH  - C-Reactive Protein/urine
MH  - Female
MH  - Humans
MH  - Nerve Growth Factor/urine
MH  - Urinary Bladder, Overactive/*diagnosis/urine
OTO - NOTNLM
OT  - biomarker
OT  - diagnosis
OT  - overactive bladder
EDAT- 2017/12/02 06:00
MHDA- 2018/07/13 06:00
CRDT- 2017/12/02 06:00
PHST- 2017/09/01 00:00 [received]
PHST- 2017/10/10 00:00 [accepted]
PHST- 2017/10/08 00:00 [revised]
PHST- 2017/12/02 06:00 [entrez]
PHST- 2017/12/02 06:00 [pubmed]
PHST- 2018/07/13 06:00 [medline]
AID - VM/OJS/J/55086 [pii]
AID - 10.5603/GP.a2017.0102 [doi]
PST - ppublish
SO  - Ginekol Pol. 2017;88(10):568-573. doi: 10.5603/GP.a2017.0102.