PMID- 29192848
OWN - NLM
STAT- MEDLINE
DCOM- 20180815
LR  - 20181202
IS  - 1521-0758 (Electronic)
IS  - 0191-3123 (Linking)
VI  - 42
IP  - 1
DP  - 2018 Jan-Feb
TI  - Effects of resveratrol on high-fructose-induced testis injury in rats.
PG  - 65-73
LID - 10.1080/01913123.2017.1397075 [doi]
AB  - This study investigated whether a high-fructose (HFr) diet changes the morphology 
      of seminiferous tubules (ST) in rats and resveratrol (RES) has a possible 
      restoring effect in this sense. Fructose (30%; w/v) was administered to rats 
      alone or together with RES (50 mg/L) in drinking water for 8 weeks. In the HFr 
      group, destruction of the germinal epithelium led to the detection of immature 
      germ cells in the lumen. HFr diet gave rise to a decrease in the ST diameters 
      (p < 0.05), Johnsen's tubular biopsy score values (p < 0.001), and an increase in 
      the apoptotic index (p < 0.05). Ultrastructurally, HFr feeding increased lipid 
      accumulation (p < 0.01), mitochondrial damage, and acrosomal abnormalities in 
      spermatogenic cells. Treatment of HFr -fed rats with RES improved the reduced ST 
      diameters and overall general histological and ultrastructural abnormalities of 
      the STs, but did not change the increased apoptotic index.
FAU - Meydanli, Elif Guzel
AU  - Meydanli EG
AD  - a Department of Histology & Embryology , Istanbul University Cerrahpasa Medical 
      Faculty , Istanbul , Turkey.
FAU - Gumusel, Asli
AU  - Gumusel A
AD  - a Department of Histology & Embryology , Istanbul University Cerrahpasa Medical 
      Faculty , Istanbul , Turkey.
FAU - Ozkan, Serbay
AU  - Ozkan S
AD  - a Department of Histology & Embryology , Istanbul University Cerrahpasa Medical 
      Faculty , Istanbul , Turkey.
FAU - Tanriverdi, Gamze
AU  - Tanriverdi G
AD  - a Department of Histology & Embryology , Istanbul University Cerrahpasa Medical 
      Faculty , Istanbul , Turkey.
FAU - Balci, M B Can
AU  - Balci MBC
AD  - b Department of Urology , G.O.P Taksim Training and Research Hospital , Istanbul 
      , Turkey.
FAU - Develi Is, Seval
AU  - Develi Is S
AD  - c Department of Biochemistry , Istanbul University Istanbul Medical Faculty , 
      Istanbul , Turkey.
FAU - Hazar, A Ismet
AU  - Hazar AI
AD  - b Department of Urology , G.O.P Taksim Training and Research Hospital , Istanbul 
      , Turkey.
FAU - Uysal, Mujdat
AU  - Uysal M
AD  - c Department of Biochemistry , Istanbul University Istanbul Medical Faculty , 
      Istanbul , Turkey.
FAU - Bekpinar, Seldag
AU  - Bekpinar S
AD  - c Department of Biochemistry , Istanbul University Istanbul Medical Faculty , 
      Istanbul , Turkey.
LA  - eng
PT  - Journal Article
DEP - 20171201
PL  - England
TA  - Ultrastruct Pathol
JT  - Ultrastructural pathology
JID - 8002867
RN  - 0 (Stilbenes)
RN  - 30237-26-4 (Fructose)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Fructose/*toxicity
MH  - Male
MH  - Microscopy, Electron, Transmission
MH  - Rats
MH  - Rats, Wistar
MH  - Resveratrol
MH  - Stilbenes/*pharmacology
MH  - Testis/*drug effects/*pathology/ultrastructure
OTO - NOTNLM
OT  - Apoptosis
OT  - electron microscopy
OT  - high-fructose diet
OT  - resveratrol
OT  - testis
EDAT- 2017/12/02 06:00
MHDA- 2018/08/16 06:00
CRDT- 2017/12/02 06:00
PHST- 2017/12/02 06:00 [pubmed]
PHST- 2018/08/16 06:00 [medline]
PHST- 2017/12/02 06:00 [entrez]
AID - 10.1080/01913123.2017.1397075 [doi]
PST - ppublish
SO  - Ultrastruct Pathol. 2018 Jan-Feb;42(1):65-73. doi: 10.1080/01913123.2017.1397075. 
      Epub 2017 Dec 1.