PMID- 29193103
OWN - NLM
STAT- MEDLINE
DCOM- 20180904
LR  - 20180904
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 58
IP  - 2
DP  - 2018 Feb
TI  - Intravenous immunoglobulin-induced acute thrombocytopenia.
PG  - 493-497
LID - 10.1111/trf.14419 [doi]
AB  - BACKGROUND: Intravenous immunoglobulin (IVIG) has known efficacy in various 
      hematologic conditions, including immune thrombocytopenic purpura. STUDY DESIGN 
      AND METHODS: We present the clinical course of a patient with splenic marginal 
      zone lymphoma, who developed acute thrombocytopenia on three consecutive 
      episodes, with nadir counts of 27 x 10(9) , 50 x 10(9) , and 9 x 10(9) /L, upon 
      administration of Intratect IVIG for hypogammaglobulinemia. An immunofluorescence 
      test applying flow cytometry and monoclonal antibody immobilization of platelet 
      antigens (MAIPA) assay were used to evaluate the reaction between IgG present in 
      the IVIG preparations and the patient's or healthy donors' platelets (PLTs). 
      RESULTS: A strong direct binding reaction was observed between the patient's PLTs 
      and Intratect IgG using both methods. A similar reaction failed to materialize 
      with controls. Binding was not antigen specific according to MAIPA. CONCLUSIONS: 
      This is the first reported case of thrombocytopenia as a possible adverse effect 
      of IVIG.
CI  - (c) 2017 AABB.
FAU - Gurevich-Shapiro, Anna
AU  - Gurevich-Shapiro A
AUID- ORCID: 0000-0001-9698-1306
AD  - Internal Medicine H, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
AD  - Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital, Rabin 
      Medical Center, Petah-Tiqwa, Israel.
AD  - Sackler School of Medicine, Tel Aviv University, Ramat-Aviv, Israel.
FAU - Bonstein, Lilach
AU  - Bonstein L
AD  - Platelet Immunology Laboratory, Rambam Medical Center, Haifa, Israel.
FAU - Spectre, Galia
AU  - Spectre G
AD  - Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital, Rabin 
      Medical Center, Petah-Tiqwa, Israel.
AD  - Sackler School of Medicine, Tel Aviv University, Ramat-Aviv, Israel.
FAU - Atweh, Nardeen
AU  - Atweh N
AD  - Platelet Immunology Laboratory, Rambam Medical Center, Haifa, Israel.
FAU - Gruenewal, Tsipora
AU  - Gruenewal T
AD  - Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital, Rabin 
      Medical Center, Petah-Tiqwa, Israel.
FAU - Shapiro, Michael
AU  - Shapiro M
AD  - Sackler School of Medicine, Tel Aviv University, Ramat-Aviv, Israel.
FAU - Tadmor, Boaz
AU  - Tadmor B
AD  - Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital, Rabin 
      Medical Center, Petah-Tiqwa, Israel.
AD  - Sackler School of Medicine, Tel Aviv University, Ramat-Aviv, Israel.
FAU - Raanani, Pia
AU  - Raanani P
AD  - Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital, Rabin 
      Medical Center, Petah-Tiqwa, Israel.
AD  - Sackler School of Medicine, Tel Aviv University, Ramat-Aviv, Israel.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20171129
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Agammaglobulinemia/blood/*drug therapy
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/administration & dosage/*adverse effects
MH  - Lymphoma, B-Cell, Marginal Zone/blood/*drug therapy
MH  - Splenic Neoplasms/blood/*drug therapy
MH  - Thrombocytopenia/blood/*chemically induced
EDAT- 2017/12/02 06:00
MHDA- 2018/09/05 06:00
CRDT- 2017/12/02 06:00
PHST- 2017/08/03 00:00 [received]
PHST- 2017/10/09 00:00 [revised]
PHST- 2017/10/18 00:00 [accepted]
PHST- 2017/12/02 06:00 [pubmed]
PHST- 2018/09/05 06:00 [medline]
PHST- 2017/12/02 06:00 [entrez]
AID - 10.1111/trf.14419 [doi]
PST - ppublish
SO  - Transfusion. 2018 Feb;58(2):493-497. doi: 10.1111/trf.14419. Epub 2017 Nov 29.