PMID- 29193677
OWN - NLM
STAT- MEDLINE
DCOM- 20190123
LR  - 20220330
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 62
IP  - 4
DP  - 2018 Feb
TI  - Gallic Acid Improves Health-Associated Biochemical Parameters and Prevents 
      Oxidative Damage of DNA in Type 2 Diabetes Patients: Results of a 
      Placebo-Controlled Pilot Study.
LID - 10.1002/mnfr.201700482 [doi]
AB  - SCOPE: Oxidative imbalance plays a key role in cancer induction and 
      cardiovascular diseases (CVD) in patients with type 2 diabetes mellitus (T2DM). 
      The aim of this study is to find out if gallic acid (GA) prevents oxidative 
      stress in diabetic patients. Therefore, we investigate its impact on oxidation of 
      DNA bases and on other health-related macromolecules. METHODS AND RESULTS: We 
      perform an intervention study (n = 19) with GA and monitored alterations of the 
      DNA stability in single cell gel electrophoresis (SCGE) assays in lymphocytes. 
      Furthermore, a panel of health-related biomarkers is measured before and after 
      consumption of GA (15 mg p(-1)  d(-1) ) for 7 d. Significant reduction of 
      oxidized purines (by 31%, p < 0.001, effect size 0.404) and pyrimidines (by 2%, 
      p < 0.022, effect size 0.089) is observed in SCGE assays. Furthermore, the plasma 
      concentrations of oxidized-LDL and C-reactive protein are reduced after the 
      intervention by 24% (p = 0.014, effect size 0.384) and 39% (p < 0.001, effect 
      size 0.686), respectively. No alterations of other biomarkers are found. 
      CONCLUSIONS: A small amount of GA (in the range of daily consumption in Central 
      Europe) prevents oxidative DNA damage and reduces markers which reflect 
      inflammation and increased risks of cancer and CVD.
CI  - (c) 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Ferk, Franziska
AU  - Ferk F
AD  - Institute of Cancer Research, Department of Internal Medicine I, Medical 
      University of Vienna, Austria.
FAU - Kundi, Michael
AU  - Kundi M
AD  - Institute for Environmental Health, Center for Public Health, Medical University 
      of Vienna, Austria.
FAU - Brath, Helmut
AU  - Brath H
AD  - Diabetes Outpatient Clinic, Health Centre South, Vienna, Austria.
FAU - Szekeres, Thomas
AU  - Szekeres T
AD  - Department of Medical and Chemical Laboratory Diagnostics, Medical University of 
      Vienna, Austria.
FAU - Al-Serori, Halh
AU  - Al-Serori H
AD  - Institute of Cancer Research, Department of Internal Medicine I, Medical 
      University of Vienna, Austria.
FAU - Misik, Miroslav
AU  - Misik M
AD  - Institute of Cancer Research, Department of Internal Medicine I, Medical 
      University of Vienna, Austria.
FAU - Saiko, Philipp
AU  - Saiko P
AD  - Department of Medical and Chemical Laboratory Diagnostics, Medical University of 
      Vienna, Austria.
FAU - Marculescu, Rodrig
AU  - Marculescu R
AD  - Department of Medical and Chemical Laboratory Diagnostics, Medical University of 
      Vienna, Austria.
FAU - Wagner, Karl-Heinz
AU  - Wagner KH
AD  - Department of Nutritional Sciences, University of Vienna, Austria.
FAU - Knasmueller, Siegfried
AU  - Knasmueller S
AD  - Institute of Cancer Research, Department of Internal Medicine I, Medical 
      University of Vienna, Austria.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180115
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (oxidized low density lipoprotein)
RN  - 632XD903SP (Gallic Acid)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - C-Reactive Protein/analysis
MH  - Cardiovascular Diseases/prevention & control
MH  - Cross-Over Studies
MH  - DNA Damage/*drug effects
MH  - Diabetes Mellitus, Type 2/complications/*metabolism
MH  - Double-Blind Method
MH  - Female
MH  - Gallic Acid/*pharmacology
MH  - Health Status
MH  - Humans
MH  - Lipoproteins, LDL/blood
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/prevention & control
MH  - Oxidative Stress/*drug effects
MH  - Pilot Projects
OTO - NOTNLM
OT  - CRP
OT  - DNA damage
OT  - SCGE assay
OT  - gallic acid
OT  - oxo-LDL
EDAT- 2017/12/02 06:00
MHDA- 2019/01/24 06:00
CRDT- 2017/12/02 06:00
PHST- 2017/06/02 00:00 [received]
PHST- 2017/11/10 00:00 [revised]
PHST- 2017/12/02 06:00 [pubmed]
PHST- 2019/01/24 06:00 [medline]
PHST- 2017/12/02 06:00 [entrez]
AID - 10.1002/mnfr.201700482 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2018 Feb;62(4). doi: 10.1002/mnfr.201700482. Epub 2018 Jan 15.