PMID- 29193910
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20180727
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 46
IP  - 2
DP  - 2018 Feb
TI  - Does noninvasive follicular thyroid neoplasm with papillary-like nuclear features 
      have distinctive features on sonography?
PG  - 139-147
LID - 10.1002/dc.23863 [doi]
AB  - BACKGROUND: The noninvasive encapsulated follicular variant of papillary 
      carcinoma (nEFVPTC) has recently been reclassified to "noninvasive follicular 
      thyroid neoplasm with papillary-like nuclear features (NIFTP)," removing this 
      entity from the malignant category. This re-categorization has had major 
      implications for clinical management. NIFTP has overlapping cytohistologic 
      features with papillary thyroid carcinoma (PTC) and with follicular adenomas 
      (FA), but sonographic data comparing NIFTP to PTC and FA is lacking. Our study 
      examines the sonographic features of NIFTP as compared with PTC and FA. METHODS: 
      Ultrasound scans and Doppler blood flow from subjects who had pre-surgical 
      sonograms and fine needle aspiration biopsies with final surgical pathology 
      diagnoses of NIFTP/nEFVPTC, classical PTC, and FA between 01/2013-08/2016 were 
      assessed. Sonographic and Doppler features as well as Bethesda System (TBS) 
      diagnoses were recorded and analyzed. RESULTS: 40 NIFTP, 58 classical PTC, and 23 
      FA cases were included. The most common NIFTP pre-surgical TBS cytology diagnosis 
      was Atypia of Undetermined Significance (AUS/FLUS) (40%). NIFTP cases 
      predominantly displayed wider-than-tall shape (100%), smooth borders (75%), 
      occurrence in multinodular glands (82.5%), heterogeneous echogenicity (50%), both 
      perinodular and intranodular Doppler flow patterns (70%), minimal Doppler flow 
      grade (62.5%), and no calcifications (90%). CONCLUSIONS: Our study demonstrates 
      that NIFTP, PTC, and FA display several distinguishing and overlapping 
      sonographic and Doppler features. Sonographic features appear to complement 
      cytology findings and may help raise pre-operative concern for NIFTP in the 
      proper clinical setting, potentially leading to a more conservative management 
      approach.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Brandler, Tamar C
AU  - Brandler TC
AUID- ORCID: 0000-0001-8272-9900
AD  - Department of Pathology, New York University School of Medicine, New York.
FAU - Yee, Joseph
AU  - Yee J
AD  - Department of Radiology, New York University School of Medicine, New York.
FAU - Zhou, Fang
AU  - Zhou F
AD  - Department of Pathology, New York University School of Medicine, New York.
FAU - Cho, Margaret
AU  - Cho M
AD  - Department of Pathology, New York University School of Medicine, New York.
FAU - Cangiarella, Joan
AU  - Cangiarella J
AD  - Department of Pathology, New York University School of Medicine, New York.
FAU - Wei, Xiao-Jun
AU  - Wei XJ
AD  - Department of Pathology, New York University School of Medicine, New York.
FAU - Yee-Chang, Melissa
AU  - Yee-Chang M
AD  - Department of Pathology, New York University School of Medicine, New York.
FAU - Sun, Wei
AU  - Sun W
AD  - Department of Pathology, New York University School of Medicine, New York.
LA  - eng
PT  - Journal Article
DEP - 20171129
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
SB  - IM
MH  - Carcinoma, Papillary, Follicular/diagnostic imaging/*pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Thyroid Neoplasms/diagnostic imaging/*pathology
MH  - Ultrasonography, Doppler/standards
OTO - NOTNLM
OT  - Doppler
OT  - FNA
OT  - NIFTP
OT  - noninvasive encapsulated follicular variant of papillary thyroid carcinoma
OT  - noninvasive follicular thyroid neoplasm with papillary-like nuclear features
OT  - ultrasound
EDAT- 2017/12/02 06:00
MHDA- 2018/07/28 06:00
CRDT- 2017/12/02 06:00
PHST- 2017/09/11 00:00 [received]
PHST- 2017/10/18 00:00 [revised]
PHST- 2017/11/06 00:00 [accepted]
PHST- 2017/12/02 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2017/12/02 06:00 [entrez]
AID - 10.1002/dc.23863 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2018 Feb;46(2):139-147. doi: 10.1002/dc.23863. Epub 2017 Nov 
      29.