PMID- 29194206
OWN - NLM
STAT- MEDLINE
DCOM- 20190802
LR  - 20190802
IS  - 1536-481X (Electronic)
IS  - 1057-0829 (Linking)
VI  - 27
IP  - 2
DP  - 2018 Feb
TI  - Predictive Factors for Visual Field Conversion: Comparison of Scanning Laser 
      Polarimetry and Optical Coherence Tomography.
PG  - 157-163
LID - 10.1097/IJG.0000000000000833 [doi]
AB  - PURPOSE: The purpose of this study was to compare the ability of scanning laser 
      polarimetry (SLP) and spectral-domain optical coherence tomography (SD-OCT) to 
      predict future visual field conversion of subjects with ocular hypertension and 
      early glaucoma. METHODS: All patients were recruited from the Erlangen glaucoma 
      registry and examined using standard automated perimetry, 24-hour intraocular 
      pressure profile, and optic disc photography. Peripapillary retinal nerve fiber 
      layer thickness (RNFL) measurements were obtained by SLP (GDx-VCC) and SD-OCT 
      (Spectralis OCT). Positive and negative predictive values (PPV, NPV) were 
      calculated for morphologic parameters of SLP and SD-OCT. Kaplan-Meier survival 
      curves were plotted and log-rank tests were performed to compare the survival 
      distributions. Contingency tables and Venn-diagrams were calculated to compare 
      the predictive ability. RESULTS: The study included 207 patients-75 with ocular 
      hypertension, 85 with early glaucoma, and 47 controls. Median follow-up was 4.5 
      years. A total of 29 patients (14.0%) developed visual field conversion during 
      follow-up. SLP temporal-inferior RNFL [0.667; 95% confidence interval (CI), 
      0.281-0.935] and SD-OCT temporal-inferior RNFL (0.571; 95% CI, 0.317-0.802) 
      achieved the highest PPV; nerve fiber indicator (0.923; 95% CI, 0.876-0.957) and 
      SD-OCT mean (0.898; 95% CI, 0.847-0.937) achieved the highest NPV of all 
      investigated parameters. The Kaplan-Meier curves confirmed significantly higher 
      survival for subjects within normal limits of measurements of both devices 
      (P<0.001). Venn diagrams tested with McNemar test statistics showed no 
      significant difference for PPV (P=0.219) or NPV (P=0.678). CONCLUSIONS: Both 
      GDx-VCC and SD-OCT demonstrate comparable results in predicting future visual 
      field conversion if taking typical scans for GDx-VCC. In addition, the likelihood 
      ratios suggest that GDx-VCC's nerve fiber indicator<30 may be the most useful 
      parameter to confirm future nonconversion. (http://www.ClinicalTrials.gov number, 
      NTC00494923; Erlangen Glaucoma Registry).
FAU - Diekmann, Theresa
AU  - Diekmann T
AD  - Department of Ophthalmology, University of Erlangen-Nuremberg, Erlangen, Germany.
FAU - Schrems-Hoesl, Laura M
AU  - Schrems-Hoesl LM
FAU - Mardin, Christian Y
AU  - Mardin CY
FAU - Laemmer, Robert
AU  - Laemmer R
FAU - Horn, Folkert K
AU  - Horn FK
FAU - Kruse, Friedrich E
AU  - Kruse FE
FAU - Schrems, Wolfgang A
AU  - Schrems WA
LA  - eng
SI  - ClinicalTrials.gov/NCT00494923
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Glaucoma
JT  - Journal of glaucoma
JID - 9300903
MH  - Aged
MH  - False Positive Reactions
MH  - Female
MH  - Follow-Up Studies
MH  - Glaucoma, Open-Angle/*diagnosis/physiopathology
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Ocular Hypertension/diagnosis/physiopathology
MH  - Predictive Value of Tests
MH  - Retinal Ganglion Cells/pathology
MH  - Retrospective Studies
MH  - Scanning Laser Polarimetry/*methods
MH  - Tomography, Optical Coherence/*methods
MH  - Tonometry, Ocular
MH  - Vision Disorders/*diagnosis/physiopathology
MH  - Visual Field Tests
MH  - Visual Fields/*physiology
EDAT- 2017/12/02 06:00
MHDA- 2019/08/03 06:00
CRDT- 2017/12/02 06:00
PHST- 2017/12/02 06:00 [pubmed]
PHST- 2019/08/03 06:00 [medline]
PHST- 2017/12/02 06:00 [entrez]
AID - 10.1097/IJG.0000000000000833 [doi]
PST - ppublish
SO  - J Glaucoma. 2018 Feb;27(2):157-163. doi: 10.1097/IJG.0000000000000833.