PMID- 29195158
OWN - NLM
STAT- MEDLINE
DCOM- 20180817
LR  - 20220316
IS  - 1873-3379 (Electronic)
IS  - 0891-4222 (Linking)
VI  - 72
DP  - 2018 Jan
TI  - Corticospinal excitability during motor imagery is reduced in young adults with 
      developmental coordination disorder.
PG  - 214-224
LID - S0891-4222(17)30303-7 [pii]
LID - 10.1016/j.ridd.2017.11.009 [doi]
AB  - While a compelling body of behavioral research suggests that individuals with 
      developmental coordination disorder (DCD) experience difficulties engaging motor 
      imagery (MI), very little is known about the neural correlates of this deficit. 
      Since corticospinal excitability is a predictor of MI proficiency in healthy 
      adults, we reasoned that decreased MI efficiency in DCD may be paralleled by 
      atypical primary motor cortex (PMC) activity. Participants were 29 young adults 
      aged 18- 36 years: 8 with DCD (DCD) and 21 controls. Six participants with DCD 
      and 15 controls showed behavioral profiles consistent with the use of a MI 
      strategy (MI users) while performing a novel adaptation of the classic hand 
      laterality task (HLT). Single-pulse transcranial magnetic stimulation (TMS) was 
      administered to the hand node of the left PMC (hPMC) at 50ms, 400ms or 650ms post 
      stimulus presentation during the HLT. Motor-evoked potentials (MEPs) were 
      recorded from the right first dorsal interosseous (FDI) via electromyography. As 
      predicted, MI users with DCD were significantly less efficient than MI using 
      controls, shown by poorer performance on the HLT. Importantly, unlike healthy 
      controls, no evidence of enhanced hPMC activity during MI was detected in our DCD 
      group. Our data are consistent with the view that inefficient MI in DCD may be 
      subserved by decreased hPMC activity. These findings are an important step 
      towards clarifying the neuro-cognitive correlates of poor MI ability and motor 
      skill in individuals with DCD.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Hyde, C
AU  - Hyde C
AD  - Deakin Child Study Centre, School of Psychology, Deakin University, Geelong, 
      Australia. Electronic address: c.hyde@deakin.edu.au.
FAU - Fuelscher, I
AU  - Fuelscher I
AD  - Deakin Child Study Centre, School of Psychology, Deakin University, Geelong, 
      Australia.
FAU - Williams, J
AU  - Williams J
AD  - Institute of Sport, Exercise and Active Living, Victoria University, Melbourne, 
      Australia.
FAU - Lum, J A G
AU  - Lum JAG
AD  - Deakin Child Study Centre, School of Psychology, Deakin University, Geelong, 
      Australia.
FAU - He, J
AU  - He J
AD  - Deakin Child Study Centre, School of Psychology, Deakin University, Geelong, 
      Australia.
FAU - Barhoun, P
AU  - Barhoun P
AD  - Deakin Child Study Centre, School of Psychology, Deakin University, Geelong, 
      Australia.
FAU - Enticott, P G
AU  - Enticott PG
AD  - Deakin Child Study Centre, School of Psychology, Deakin University, Geelong, 
      Australia.
LA  - eng
PT  - Journal Article
DEP - 20171128
PL  - United States
TA  - Res Dev Disabil
JT  - Research in developmental disabilities
JID - 8709782
SB  - IM
MH  - Adaptation, Physiological
MH  - Adult
MH  - Electromyography/methods
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Functional Laterality
MH  - *Hand/physiology/physiopathology
MH  - Humans
MH  - Imagination/*physiology
MH  - Male
MH  - Motor Cortex/physiology
MH  - Motor Skills/*physiology
MH  - *Motor Skills Disorders/diagnosis/physiopathology/psychology
MH  - Transcranial Magnetic Stimulation/methods
OTO - NOTNLM
OT  - Corticospinal excitability
OT  - Developmental coordination disorder
OT  - Hand laterality task
OT  - Motor imagery
OT  - Primary motor cortex
OT  - TMS
EDAT- 2017/12/02 06:00
MHDA- 2018/08/18 06:00
CRDT- 2017/12/02 06:00
PHST- 2017/05/25 00:00 [received]
PHST- 2017/11/01 00:00 [revised]
PHST- 2017/11/19 00:00 [accepted]
PHST- 2017/12/02 06:00 [pubmed]
PHST- 2018/08/18 06:00 [medline]
PHST- 2017/12/02 06:00 [entrez]
AID - S0891-4222(17)30303-7 [pii]
AID - 10.1016/j.ridd.2017.11.009 [doi]
PST - ppublish
SO  - Res Dev Disabil. 2018 Jan;72:214-224. doi: 10.1016/j.ridd.2017.11.009. Epub 2017 
      Nov 28.