PMID- 29197592
OWN - NLM
STAT- MEDLINE
DCOM- 20180202
LR  - 20180202
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 646
DP  - 2018 Mar 10
TI  - Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by 
      interfering p65 nuclear translocation.
PG  - 47-55
LID - S0378-1119(17)31035-1 [pii]
LID - 10.1016/j.gene.2017.11.070 [doi]
AB  - Porcine butyrophilin-like 5 (Btnl5) is a novel member of the butyrophilin family, 
      which consists of immune regulators. The expression pattern and the function of 
      this gene remain unclear. In this study, Btnl5 is identified as a negative 
      regulator of the NF-kappaB pathway. Our study indicates that Btnl5 is mainly 
      expressed in intestinal epithelial cells (IECs) and expressed in membrane 
      systems. Btnl5 inhibits MyD88-mediated activation of the NF-kappaB pathway. Btnl5 
      interacts with TNF receptor-associated factor 2 (TRAF2) and transcription factor 
      p65. Besides, Btnl5 inhibits p65-mediated activation of the NF-kappaB pathway and 
      inhibits nuclear translocation of p65. These results suggest that Btnl5 may 
      inhibit NF-kappaB pathway through binding and interfere nuclear translocation of p65.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Bao, Qi
AU  - Bao Q
AD  - Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute 
      of Plateau Biology, Chinese Academy of Sciences, Xining 810001, China; Laboratory 
      of Plateau Fish Evolutionary and Functional Genomics, Northwest Institute of 
      Plateau Biology, Chinese Academy of Sciences, Xining 810001, China; Genetic 
      Resource Center, Institute of Genetics and Developmental Biology, Chinese Academy 
      of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, 
      Beijing 100049, China.
FAU - Li, Chong
AU  - Li C
AD  - Core Facility for Protein Research, Institute of Biophysics, Chinese Academy of 
      Sciences, Beijing 100101, China.
FAU - Xu, Chongfeng
AU  - Xu C
AD  - Genetic Resource Center, Institute of Genetics and Developmental Biology, Chinese 
      Academy of Sciences, Beijing 100101, China.
FAU - Zhang, Ruiying
AU  - Zhang R
AD  - Genetic Resource Center, Institute of Genetics and Developmental Biology, Chinese 
      Academy of Sciences, Beijing 100101, China.
FAU - Zhao, Kai
AU  - Zhao K
AD  - Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute 
      of Plateau Biology, Chinese Academy of Sciences, Xining 810001, China; Laboratory 
      of Plateau Fish Evolutionary and Functional Genomics, Northwest Institute of 
      Plateau Biology, Chinese Academy of Sciences, Xining 810001, China. Electronic 
      address: zhaokai@neopb.ac.cn.
FAU - Duan, Ziyuan
AU  - Duan Z
AD  - Genetic Resource Center, Institute of Genetics and Developmental Biology, Chinese 
      Academy of Sciences, Beijing 100101, China. Electronic address: 
      zyduan@genetics.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20171129
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Butyrophilins)
RN  - 0 (Transcription Factor RelA)
SB  - IM
MH  - Animals
MH  - Butyrophilins/*metabolism
MH  - Cell Line
MH  - Cell Nucleus/*metabolism
MH  - Enterocytes/cytology/*metabolism
MH  - Gene Expression Regulation
MH  - HEK293 Cells
MH  - Humans
MH  - Intestine, Small/metabolism
MH  - Protein Transport
MH  - Signal Transduction
MH  - Swine
MH  - Transcription Factor RelA/*metabolism
OTO - NOTNLM
OT  - Btnl5
OT  - IECs
OT  - Immune regulation
OT  - Interacting proteins
OT  - NF-kappaB
EDAT- 2017/12/05 06:00
MHDA- 2018/02/03 06:00
CRDT- 2017/12/04 06:00
PHST- 2017/07/02 00:00 [received]
PHST- 2017/11/12 00:00 [revised]
PHST- 2017/11/28 00:00 [accepted]
PHST- 2017/12/05 06:00 [pubmed]
PHST- 2018/02/03 06:00 [medline]
PHST- 2017/12/04 06:00 [entrez]
AID - S0378-1119(17)31035-1 [pii]
AID - 10.1016/j.gene.2017.11.070 [doi]
PST - ppublish
SO  - Gene. 2018 Mar 10;646:47-55. doi: 10.1016/j.gene.2017.11.070. Epub 2017 Nov 29.