PMID- 29198013
OWN - NLM
STAT- MEDLINE
DCOM- 20181001
LR  - 20181113
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 41
IP  - 2
DP  - 2018 Mar
TI  - Short- and Long-Term Protective Effects of Melatonin in a Mouse Model of 
      Sepsis-Associated Encephalopathy.
PG  - 515-529
LID - 10.1007/s10753-017-0708-0 [doi]
AB  - Brain dysfunction is a common complication after sepsis and is an independent 
      risk factor for a poor prognosis, which is partly attributed to the dysregulated 
      inflammatory response and oxidative damage. Melatonin regulates the sleep-wake 
      cycle and also has potent anti-inflammatory and antioxidant properties, yet the 
      protective effects of melatonin on sepsis-induced neurobehavioral dysfunction 
      remain to be elucidated. In the present study, melatonin was administered 
      intraperitoneally daily at a dose of 10 mg/kg for three consecutive days 
      immediately (early treatment) or 7 days (delayed treatment) after sham operation 
      or cecal ligation and puncture (CLP), followed by an additional treatment in 
      drinking water until the end of behavioral tests. The concentrations of 
      pro-inflammatory cytokines (tumor necrosis factor (TNF-alpha), interleukin-1beta 
      (IL-1beta), IL-6, IL-10), malondialdehyde (MDA), superoxide dismutase (SOD), 
      reactive oxygen species (ROS), brain-derived neurotrophic factor (BDNF), and 
      glial cell line-derived neurotrophic factor (GDNF) were determined at the 
      indicated time points. Compared with the CLP + vehicle group, we found that early 
      melatonin treatment resulted in increased survival rate but not improvement in 
      measures of neurobehavioral outcomes, which was accompanied by significantly 
      lower plasma level of IL-1beta. Intriguingly, delayed melatonin treatment improved 
      neurobehavioral dysfunction by normalization of hippocampal BDNF and GDNF 
      expressions. In conclusion, our study suggests the beneficial effects of both 
      early and delayed melatonin treatment after sepsis development, which implicates 
      melatonin has a potential therapeutic value in sepsis-associated organ damage 
      including brain dysfunction.
FAU - Ji, Mu-Huo
AU  - Ji MH
AD  - Department of Anesthesiology, Jinling Clinical Medical College of Nanjing Medical 
      University, Nanjing, China.
FAU - Xia, De-Guo
AU  - Xia DG
AD  - Department of Anesthesiology, Clinical Medical College of Yangzhou University 
      (Subei People's Hospital of Jiangsu Province), Yangzhou, Jiangsu Province, China.
FAU - Zhu, Lan-Yue
AU  - Zhu LY
AD  - Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast 
      University, Nanjing, China.
FAU - Zhu, Xia
AU  - Zhu X
AD  - Department of Anesthesiology, Jinling Clinical Medical College of Nanjing Medical 
      University, Nanjing, China.
FAU - Zhou, Xiao-Yan
AU  - Zhou XY
AD  - Department of Anesthesiology, Jinling Clinical Medical College of Nanjing Medical 
      University, Nanjing, China.
FAU - Xia, Jiang-Yan
AU  - Xia JY
AD  - Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast 
      University, Nanjing, China.
FAU - Yang, Jian-Jun
AU  - Yang JJ
AD  - Department of Anesthesiology, Jinling Clinical Medical College of Nanjing Medical 
      University, Nanjing, China. yjyangjj@126.com.
LA  - eng
GR  - 81771156/National Science Foundation of China/
GR  - 81471105,81772126/National Natural Science Foundation of China (CN)/
PT  - Journal Article
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Protective Agents)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cytokines/analysis
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - Hippocampus/metabolism
MH  - Melatonin/administration & dosage/*pharmacology/therapeutic use
MH  - Mice
MH  - Protective Agents/pharmacology
MH  - Sepsis-Associated Encephalopathy/*drug therapy
MH  - Survival Rate
MH  - Time Factors
OTO - NOTNLM
OT  - cognitive function
OT  - melatonin
OT  - neuroplasticity
OT  - sepsis
EDAT- 2017/12/05 06:00
MHDA- 2018/10/03 06:00
CRDT- 2017/12/04 06:00
PHST- 2017/12/05 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2017/12/04 06:00 [entrez]
AID - 10.1007/s10753-017-0708-0 [pii]
AID - 10.1007/s10753-017-0708-0 [doi]
PST - ppublish
SO  - Inflammation. 2018 Mar;41(2):515-529. doi: 10.1007/s10753-017-0708-0.