PMID- 29199160
OWN - NLM
STAT- MEDLINE
DCOM- 20180724
LR  - 20180724
IS  - 2148-5607 (Electronic)
IS  - 1300-4948 (Linking)
VI  - 28
IP  - Suppl 1
DP  - 2017 Dec
TI  - What is the place of empirical proton pump inhibitor testing in the diagnosis of 
      gastroesophageal reflux disease? (Description, duration, and dosage).
PG  - S12-S15
LID - 10.5152/tjg.2017.05 [doi]
AB  - Empirical acid suppression tests that are performed with proton pump inhibitors 
      (PPI) are used to detect both the presence of acid-related gastrointestinal 
      symptoms and gastroesophageal reflux disease (GERD). In comparison to other 
      diagnostic methods, it is non-invasive, easily applicable, and cost-effective in 
      the diagnosis of GERD. In addition to typical reflux symptoms, it can also be 
      used for diagnostic purposes in patients with non-cardiac chest pain (NCCP). If 
      the symptom response is 50% and above when obtained using the PPI test in 
      patients with NCCP, it can be considered as positive and the treatment should be 
      continued sensitivity of the PPI test in patients with typical symptoms of GERD 
      is 27%-89%, while its specificity is 35%-83%. Although there are differences 
      related to the duration and dosage of the PPI test, a significant difference has 
      not been found according to the type of PPI. When PPI test sensitivity and 
      specificity were calculated by cumulatively evaluating the data regarding the PPI 
      test in the literature, a sensitivity of 82.3% and specificity of 51.5% was 
      obtained. It has been found that high doses of PPI were mostly used in studies, 
      and the duration of the median test was 14 days. As a result, the sensitivity of 
      PPI trial test is good, but the specificity is low in the diagnosis of GERD in 
      patients with typical reflux symptoms.
FAU - Vardar, Rukiye
AU  - Vardar R
AD  - Department of Gastroenterology, Ege University School of Medicine, Izmir, Turkey
FAU - Keskin, Muharrem
AU  - Keskin M
AD  - Department of Gastroenterology, Necmettin Erbakan University School of Medicine, 
      Konya, Turkey
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Turkey
TA  - Turk J Gastroenterol
JT  - The Turkish journal of gastroenterology : the official journal of Turkish Society 
      of Gastroenterology
JID - 9515841
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Chest Pain/*diagnosis
MH  - Female
MH  - Gastroesophageal Reflux/*diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/administration & dosage/*therapeutic use
MH  - Sensitivity and Specificity
MH  - Symptom Assessment/*methods
EDAT- 2017/12/05 06:00
MHDA- 2018/07/25 06:00
CRDT- 2017/12/05 06:00
PHST- 2017/12/05 06:00 [entrez]
PHST- 2017/12/05 06:00 [pubmed]
PHST- 2018/07/25 06:00 [medline]
AID - 10.5152/tjg.2017.05 [doi]
PST - ppublish
SO  - Turk J Gastroenterol. 2017 Dec;28(Suppl 1):S12-S15. doi: 10.5152/tjg.2017.05.