PMID- 29199261
OWN - NLM
STAT- MEDLINE
DCOM- 20180809
LR  - 20181113
IS  - 2185-4610 (Electronic)
IS  - 0016-2590 (Print)
IS  - 0016-2590 (Linking)
VI  - 63
IP  - 3
DP  - 2017 Dec 19
TI  - TBX19 is overexpressed in colorectal cancer and associated with lymph node 
      metastasis.
PG  - 141-151
LID - 10.5387/fms.2017-08 [doi]
AB  - The T-box 19 (TBX19) gene encodes a transcription factor characterized by a 
      highly conserved DNA-binding motif (T-box). Recent studies have revealed that 
      TBX19 has been identified as one of the genes activated by KRAS mutations, and is 
      upregulated in colon adenoma. These results indicate that TBX19 may work as an 
      oncogene in colorectal cancer (CRC). However, the expression and role of TBX19 
      have yet to be investigated. Here, we investigated TBX19 mRNA and protein 
      expressions in colon cancer cells or surgically resected CRC. We found that TBX19 
      mRNA expression was significantly increased in tumorous tissues compared to that 
      in non-tumorous tissues, and increased TBX19 mRNA expression was associated with 
      positive lymph node metastasis in our cohort. The expression of TBX19 mRNA was 
      not correlated with that of TBX19 protein in tissue sample taken from the CRC 
      patients. Moreover, TBX19 showed positive staining even in the normal colonic 
      tissues and the adjacent non-tumorous tissues. These results suggest that the 
      expression of TBX19 protein is not correlated with the expression of TBX19 mRNA. 
      In addition, our results promote further investigations into the impact of TBX19 
      upregulation on colorectal carcinogenesis, as well as the underlying mechanisms.
FAU - Ando, Jin
AU  - Ando J
AD  - Department of Gastrointestinal Tract Surgery, Fukushima Medical University School 
      of Medicine.
FAU - Saito, Motonobu
AU  - Saito M
AD  - Department of Gastrointestinal Tract Surgery, Fukushima Medical University School 
      of Medicine.
FAU - Imai, Jun-Ichi
AU  - Imai JI
AD  - Medical-Industrial Translational Research Center, Fukushima Medical University.
FAU - Ito, Emi
AU  - Ito E
AD  - Medical-Industrial Translational Research Center, Fukushima Medical University.
FAU - Yanagisawa, Yuka
AU  - Yanagisawa Y
AD  - Nippon Gene Co., Ltd.
FAU - Honma, Reiko
AU  - Honma R
AD  - Nippon Gene Co., Ltd.
FAU - Saito, Katsuharu
AU  - Saito K
AD  - Department of Gastrointestinal Tract Surgery, Fukushima Medical University School 
      of Medicine.
FAU - Tachibana, Kazunoshin
AU  - Tachibana K
AD  - Department of Breast Surgery, Fukushima Medical University School of Medicine.
FAU - Momma, Tomoyuki
AU  - Momma T
AD  - Department of Gastrointestinal Tract Surgery, Fukushima Medical University School 
      of Medicine.
FAU - Ohki, Shinji
AU  - Ohki S
AD  - Department of Gastrointestinal Tract Surgery, Fukushima Medical University School 
      of Medicine.
FAU - Ohtake, Tohru
AU  - Ohtake T
AD  - Department of Breast Surgery, Fukushima Medical University School of Medicine.
FAU - Watanabe, Shinya
AU  - Watanabe S
AD  - Medical-Industrial Translational Research Center, Fukushima Medical University.
FAU - Waguri, Satoshi
AU  - Waguri S
AD  - Department of Anatomy and Histology, Fukushima Medical University School of 
      Medicine.
FAU - Kono, Koji
AU  - Kono K
AD  - Department of Gastrointestinal Tract Surgery, Fukushima Medical University School 
      of Medicine.
FAU - Takenoshita, Seiichi
AU  - Takenoshita S
AD  - Department of Gastrointestinal Tract Surgery, Fukushima Medical University School 
      of Medicine.
LA  - eng
PT  - Journal Article
DEP - 20171201
PL  - Japan
TA  - Fukushima J Med Sci
JT  - Fukushima journal of medical science
JID - 0374626
RN  - 0 (Homeodomain Proteins)
RN  - 0 (KRAS protein, human)
RN  - 0 (RNA, Messenger)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (TBX19 protein, human)
RN  - EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras))
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cell Line, Tumor
MH  - Colorectal Neoplasms/genetics/metabolism/*pathology
MH  - Female
MH  - Homeodomain Proteins/analysis/genetics/*physiology
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Mutation
MH  - Proto-Oncogene Proteins p21(ras)/genetics
MH  - RNA, Messenger/analysis
MH  - T-Box Domain Proteins/analysis/genetics/*physiology
PMC - PMC5792498
OTO - NOTNLM
OT  - TBX19
OT  - colorectal cancer
OT  - cytoplasmic granular signal
OT  - diagnostic biomarker
OT  - lymph node metastasis
EDAT- 2017/12/05 06:00
MHDA- 2018/08/10 06:00
PMCR- 2017/01/01
CRDT- 2017/12/05 06:00
PHST- 2017/12/05 06:00 [pubmed]
PHST- 2018/08/10 06:00 [medline]
PHST- 2017/12/05 06:00 [entrez]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.5387/fms.2017-08 [doi]
PST - ppublish
SO  - Fukushima J Med Sci. 2017 Dec 19;63(3):141-151. doi: 10.5387/fms.2017-08. Epub 
      2017 Dec 1.