PMID- 29199483
OWN - NLM
STAT- MEDLINE
DCOM- 20181102
LR  - 20181102
IS  - 1465-3478 (Electronic)
IS  - 0963-7486 (Linking)
VI  - 69
IP  - 6
DP  - 2018 Sep
TI  - Anthropometric and metabolic improvements in human type 2 diabetes after 
      introduction of an Okinawan-based Nordic diet are not associated with changes in 
      microbial diversity or SCFA concentrations.
PG  - 729-740
LID - 10.1080/09637486.2017.1408059 [doi]
AB  - The Okinawan-based Nordic (O-BN) diet improves anthropometry and metabolism in 
      type 2 diabetes mellitus (T2DM) patients. The aim of this study was to study 
      mechanisms behind improvements by examining Enterobacteriaceae abundance, 
      microbial diversity, and concentrations of short-chain fatty acids (SCFAs). A 
      secondary aim was exploring if metformin treatment affects microbiota or SCFAs. 
      Thirty T2DM patients received the O-BN diet for 12 weeks. Faecal and blood 
      samples were collected at baseline, 12 and 28 weeks. Although patients 
      experienced weight loss and improved metabolic parameters, there were no 
      significant changes in Enterobacteriaceae abundance or microbial diversity. 
      Patients on metformin displayed higher Enterobacteriaceae abundance throughout 
      the study (p = .008, p = .038, and p = .001, respectively). Isovaleric acid was 
      decreased after 12 weeks (p = .018). Butyric acid was decreased at follow-up 
      (p = .007). Improved anthropometry and metabolism in T2DM after introduction of 
      the O-BN diet is not associated with changes in Enterobacteriaceae abundance, 
      microbial diversity or SCFA concentrations.
FAU - Huang, Fang
AU  - Huang F
AD  - a Food for Health Science Centre , Lund University , Lund , Sweden.
FAU - Nilholm, Clara
AU  - Nilholm C
AD  - b Department of Internal Medicine , Skane University Hospital, Lund University , 
      Malmo , Sweden.
FAU - Roth, Bodil
AU  - Roth B
AD  - b Department of Internal Medicine , Skane University Hospital, Lund University , 
      Malmo , Sweden.
FAU - Linninge, Caroline
AU  - Linninge C
AD  - c Department of Food Technology, Engineering and Nutrition , Lund University , 
      Lund , Sweden.
FAU - Hoglund, Peter
AU  - Hoglund P
AD  - d Department of Clinical Chemistry & Pharmacology , Skane University Hospital, 
      Lund University , Lund , Sweden.
FAU - Nyman, Margareta
AU  - Nyman M
AD  - a Food for Health Science Centre , Lund University , Lund , Sweden.
FAU - Ohlsson, Bodil
AU  - Ohlsson B
AD  - b Department of Internal Medicine , Skane University Hospital, Lund University , 
      Malmo , Sweden.
LA  - eng
PT  - Journal Article
DEP - 20171204
PL  - England
TA  - Int J Food Sci Nutr
JT  - International journal of food sciences and nutrition
JID - 9432922
RN  - 0 (Dietary Fiber)
RN  - 0 (Fatty Acids, Volatile)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*diet therapy/microbiology
MH  - Diet/*classification
MH  - *Diet, Reducing
MH  - Dietary Fiber
MH  - Fatty Acids, Volatile/*blood
MH  - Feces/microbiology
MH  - Female
MH  - Gastrointestinal Microbiome
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sweden
MH  - Young Adult
OTO - NOTNLM
OT  - Enterobacteriaceae
OT  - Okinawan-based Nordic diet
OT  - microbial diversity
OT  - short-chain fatty acids (SCFA)
EDAT- 2017/12/05 06:00
MHDA- 2018/11/06 06:00
CRDT- 2017/12/05 06:00
PHST- 2017/12/05 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2017/12/05 06:00 [entrez]
AID - 10.1080/09637486.2017.1408059 [doi]
PST - ppublish
SO  - Int J Food Sci Nutr. 2018 Sep;69(6):729-740. doi: 10.1080/09637486.2017.1408059. 
      Epub 2017 Dec 4.