PMID- 29199894
OWN - NLM
STAT- MEDLINE
DCOM- 20180817
LR  - 20180828
IS  - 1521-0499 (Electronic)
IS  - 0190-2148 (Linking)
VI  - 43
IP  - 9-10
DP  - 2017 Nov-Dec
TI  - Local and systemic effects of a silver nitrate coated indwelling pleural catheter 
      in an animal model of pleurodesis.
PG  - 388-394
LID - 10.1080/01902148.2017.1384865 [doi]
AB  - Purpose/Aim of the study: This study assessed the safety and potential toxicity 
      of a silver nitrate coated indwelling pleural catheter (SNCIPC) designed to 
      create pleurodesis in a large animal model. MATERIALS AND METHODS: Sixteen 
      animals underwent insertion of either a SNCIPC or an uncoated silicone catheter. 
      Half of the animals were sacrificed at day 7 and the others at day 30. Animal 
      weight and assessment of well-being, pleural fluid and blood collection were 
      performed at regular intervals. Pleurodesis was assessed at necropsy and 
      histopathological examination of organs performed. RESULTS: No mortality or 
      significant clinical findings were observed throughout the experiment. SNCIPC 
      treated animals had increased pleural fluid drainage overall (p < 0.001) and 
      specifically on days 1-4. No differences in hemoglobin, white blood cell count or 
      neutrophil counts were detected between groups. No treatment related histological 
      findings were observed in any of the evaluated tissues outside of the treated 
      area. Serum silver levels in SNCIPC catheter treated animals peaked on Day 4 
      (0.185 mug/mL, 30 day group) then gradually decreased for the remainder of the 
      study period. The highest tissue silver concentrations were noted in the SNCIPC 
      groups in tissues close to the treatment site in addition to the liver (59.8ug/g 
      +/- 8.6 and 73.3ug/g +/- 25). Pleurodesis scores were significantly higher in 
      SNCIPC treated animals for both the 7 day (median 6.5 vs. 1.0, p = 0.029) and 
      30 day cohorts (median 7.0 vs. 1.5, p = 0.029). CONCLUSIONS: SNCIPC are well 
      tolerated and not associated with any significant signs of toxicity. Silver 
      levels were elevated in local tissues, serum and liver but without evidence of 
      pathological impact. Effective pleurodesis was present by day 7 and more 
      established by day 30. Clinical studies to investigate the safety and efficacy of 
      this device in patients with malignant pleural effusions appear warranted.
FAU - Tremblay, Alain
AU  - Tremblay A
AUID- ORCID: 0000-0002-0025-7426
AD  - a Department of Medicine , University of Calgary Cumming School of Medicine , 
      Calgary , AB. Canada.
FAU - Kearney, Christine T
AU  - Kearney CT
AD  - b Becton, Dickinson and Company Inc. , Vernon Hills , Illinois , USA.
FAU - Hanks, Chris
AU  - Hanks C
AD  - c Sinclair Research Center L.L.C , Auxvasse , MO , USA.
FAU - Hughes Hanks, Jennifer
AU  - Hughes Hanks J
AD  - c Sinclair Research Center L.L.C , Auxvasse , MO , USA.
FAU - White, David S
AU  - White DS
AD  - c Sinclair Research Center L.L.C , Auxvasse , MO , USA.
FAU - Pereira, Marcia E
AU  - Pereira ME
AD  - d Histo-Scientific Research Laboratories Inc. , Mount Jackson , VA , USA.
FAU - Zook, Craig E
AU  - Zook CE
AD  - d Histo-Scientific Research Laboratories Inc. , Mount Jackson , VA , USA.
FAU - Sargis, Karen
AU  - Sargis K
AD  - b Becton, Dickinson and Company Inc. , Vernon Hills , Illinois , USA.
FAU - Zhang, Luke
AU  - Zhang L
AD  - c Sinclair Research Center L.L.C , Auxvasse , MO , USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171204
PL  - England
TA  - Exp Lung Res
JT  - Experimental lung research
JID - 8004944
RN  - 0 (Coated Materials, Biocompatible)
RN  - 3M4G523W1G (Silver)
RN  - 95IT3W8JZE (Silver Nitrate)
SB  - IM
MH  - Animals
MH  - Catheters, Indwelling/adverse effects/*standards
MH  - Coated Materials, Biocompatible/chemistry
MH  - *Pleura
MH  - Pleurodesis/*methods
MH  - Silver/analysis/pharmacokinetics
MH  - Silver Nitrate/*therapeutic use/toxicity
MH  - Tissue Distribution
OTO - NOTNLM
OT  - cancer
OT  - pleural effusion
OT  - pleurodesis
OT  - silver nitrate
EDAT- 2017/12/05 06:00
MHDA- 2018/08/18 06:00
CRDT- 2017/12/05 06:00
PHST- 2017/12/05 06:00 [pubmed]
PHST- 2018/08/18 06:00 [medline]
PHST- 2017/12/05 06:00 [entrez]
AID - 10.1080/01902148.2017.1384865 [doi]
PST - ppublish
SO  - Exp Lung Res. 2017 Nov-Dec;43(9-10):388-394. doi: 10.1080/01902148.2017.1384865. 
      Epub 2017 Dec 4.