PMID- 29200666 OWN - NLM STAT- MEDLINE DCOM- 20180709 LR - 20181113 IS - 1466-1861 (Electronic) IS - 0962-9351 (Print) IS - 0962-9351 (Linking) VI - 2017 DP - 2017 TI - Prevention of Memory Impairment and Neurotrophic Factors Increased by Lithium in Wistar Rats Submitted to Pneumococcal Meningitis Model. PG - 6490652 LID - 10.1155/2017/6490652 [doi] LID - 6490652 AB - The aim of this study was to investigate the effects of lithium on brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial cell line-derived neurotrophic factor (GDNF) expression in the hippocampus and on memory in experimental pneumococcal meningitis. The mood-stabilizer lithium is known as a neuroprotective agent with many effects on the brain. In this study, animals received either artificial cerebrospinal fluid or Streptococcus pneumoniae suspension at a concentration of 5 x 10(9) CFU/mL. Eighteen hours after induction, all animals received ceftriaxone. The animals received saline or lithium (47.5 mg/kg) or tamoxifen (1 mg/kg) as adjuvant treatment, and they were separated into six groups: control/saline, control/lithium, control/tamoxifen, meningitis/saline, meningitis/lithium, and meningitis/tamoxifen. Ten days after meningitis induction, animals were subjected to open-field habituation and the step-down inhibitory avoidance tasks. Immediately after these tasks, the animals were killed and their hippocampus was removed to evaluate the expression of BDNF, NGF, and GDNF. In the meningitis group, treatment with lithium and tamoxifen resulted in improvement in memory. Meningitis group showed decreased expression of BDNF and GDNF in the hippocampus while lithium reestablished the neurotrophin expression. Lithium was able to prevent memory impairment and reestablishes hippocampal neurotrophin expression in experimental pneumococcal meningitis. FAU - Simoes, Lutiana R AU - Simoes LR AD - Laboratory of Experimental Microbiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil. FAU - Abreu, Roberta R E S AU - Abreu RRES AD - Laboratory of Experimental Microbiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil. FAU - Generoso, Jaqueline S AU - Generoso JS AUID- ORCID: 0000-0003-0571-6764 AD - Laboratory of Experimental Microbiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil. FAU - Goularte, Jessica A AU - Goularte JA AD - Laboratory of Experimental Microbiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil. FAU - Collodel, Allan AU - Collodel A AD - Laboratory of Experimental Microbiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil. FAU - Giridharan, Vijayasree Vayalanellore AU - Giridharan VV AD - Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA. FAU - Arumanayagam, Anitha Christy Sigamani AU - Arumanayagam ACS AUID- ORCID: 0000-0001-6924-0705 AD - Department of Pathology, Houston Methodist Research Institute, Houston, TX 77030, USA. FAU - Valvassori, Samira S AU - Valvassori SS AUID- ORCID: 0000-0002-7314-6946 AD - Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil. FAU - Quevedo, Joao AU - Quevedo J AUID- ORCID: 0000-0003-3114-6611 AD - Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA. AD - Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil. AD - Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA. AD - Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. FAU - Barichello, Tatiana AU - Barichello T AUID- ORCID: 0000-0001-7776-8454 AD - Laboratory of Experimental Microbiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil. AD - Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA. LA - eng PT - Journal Article DEP - 20171022 PL - United States TA - Mediators Inflamm JT - Mediators of inflammation JID - 9209001 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Glial Cell Line-Derived Neurotrophic Factor) RN - 0 (Neuroprotective Agents) RN - 9FN79X2M3F (Lithium) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/metabolism MH - Disease Models, Animal MH - Glial Cell Line-Derived Neurotrophic Factor/metabolism MH - Hippocampus/drug effects/*metabolism MH - Lithium/*therapeutic use MH - Male MH - Memory Disorders/*metabolism/*prevention & control MH - Meningitis, Pneumococcal/*metabolism MH - Neuroprotective Agents/*therapeutic use MH - Rats MH - Rats, Wistar PMC - PMC5671739 EDAT- 2017/12/05 06:00 MHDA- 2018/07/10 06:00 PMCR- 2017/10/22 CRDT- 2017/12/05 06:00 PHST- 2017/02/19 00:00 [received] PHST- 2017/09/10 00:00 [accepted] PHST- 2017/12/05 06:00 [entrez] PHST- 2017/12/05 06:00 [pubmed] PHST- 2018/07/10 06:00 [medline] PHST- 2017/10/22 00:00 [pmc-release] AID - 10.1155/2017/6490652 [doi] PST - ppublish SO - Mediators Inflamm. 2017;2017:6490652. doi: 10.1155/2017/6490652. Epub 2017 Oct 22.