PMID- 29201217
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 14
IP  - 5
DP  - 2017 Nov
TI  - Curcumin inhibits the development of non-small cell lung cancer by inhibiting 
      autophagy and apoptosis.
PG  - 5075-5080
LID - 10.3892/etm.2017.5172 [doi]
AB  - Among patients with primary lung cancer, 75-80% present with non-small cell lung 
      cancer (NSCLC). However, there is a lack of studies into the potential preventive 
      effects of curcumin against the activation of autophagy in NSCLC. Therefore, the 
      present study primarily focused on the protective role of curcumin in NSCLC. It 
      was demonstrated that curcumin decreased the viability of the human lung cancer 
      cells lines, A549 and H1299, in a time-and dose-dependent manner (P<0.05). 
      Treatment with curcumin also suppressed the colony formation capacities of A549 
      and H1299 cells. Following incubation with 10 microM curcumin for 48 h, cell 
      apoptosis was significantly increased by 2.35- and 3.02-fold in A549 and H1299 
      cells, respectively, when compared with controls (P<0.01). Furthermore, curcumin 
      treatment markedly increased the number and volume of autophagosomes in A549 and 
      H1299 cells when compared with controls. Treatment with 10 microM curcumin for 48 h 
      also significantly reduced the phosphorylation levels of mechanistic target of 
      rapamycin (mTOR), ribosomal protein S6, phosphoinositide 3-kinase and AKT 
      (protein kinase B) in A549 and H1299 cells (P<0.05). These data indicated that 
      curcumin enhanced autophagy and apoptosis in NSCLC cells by acting as an mTOR 
      complex1/2 inhibitor.
FAU - Wang, Aili
AU  - Wang A
AD  - Department of Respiratory and Critical Care Medicine, Beijing Luhe Hospital, 
      Capital Medical University, Beijing 101100, P.R. China.
FAU - Wang, Jinxiang
AU  - Wang J
AD  - Department of Respiratory and Critical Care Medicine, Beijing Luhe Hospital, 
      Capital Medical University, Beijing 101100, P.R. China.
FAU - Zhang, Shuming
AU  - Zhang S
AD  - Department of Respiratory and Critical Care Medicine, Beijing Luhe Hospital, 
      Capital Medical University, Beijing 101100, P.R. China.
FAU - Zhang, Hongxia
AU  - Zhang H
AD  - Department of Respiratory and Critical Care Medicine, Beijing Luhe Hospital, 
      Capital Medical University, Beijing 101100, P.R. China.
FAU - Xu, Zhenyang
AU  - Xu Z
AD  - Department of Respiratory and Critical Care Medicine, Beijing Luhe Hospital, 
      Capital Medical University, Beijing 101100, P.R. China.
FAU - Li, Xiaohui
AU  - Li X
AD  - Department of Respiratory and Critical Care Medicine, Beijing Luhe Hospital, 
      Capital Medical University, Beijing 101100, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170921
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5704273
OTO - NOTNLM
OT  - apoptosis
OT  - autophagy
OT  - curcumin
OT  - non-small cell lung cancer
EDAT- 2017/12/05 06:00
MHDA- 2017/12/05 06:01
PMCR- 2017/09/21
CRDT- 2017/12/05 06:00
PHST- 2016/09/06 00:00 [received]
PHST- 2017/05/15 00:00 [accepted]
PHST- 2017/12/05 06:00 [entrez]
PHST- 2017/12/05 06:00 [pubmed]
PHST- 2017/12/05 06:01 [medline]
PHST- 2017/09/21 00:00 [pmc-release]
AID - ETM-0-0-5172 [pii]
AID - 10.3892/etm.2017.5172 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Nov;14(5):5075-5080. doi: 10.3892/etm.2017.5172. Epub 2017 Sep 
      21.