PMID- 29201327
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2008-6164 (Print)
IS  - 2008-6172 (Electronic)
IS  - 2008-6164 (Linking)
VI  - 8
IP  - 4
DP  - 2017 Fall
TI  - Stiff person case misdiagnosed as conversion disorder: A case report.
PG  - 329-331
LID - 10.22088/cjim.8.4.329 [doi]
AB  - BACKGROUND: Stiff person syndrome (SPS) is a rare neurological disease resulting 
      in stiffness and spasm of muscles. It initially affects the axial muscles and 
      then spread to limb muscles. Emotional stress exacerbated the symptoms and signs 
      of the disease. The pathophysiology of the disease is caused by the decreased 
      level of the glutamic acid decarboxylase (GAD) activity due to an autoantibody 
      against GAD that decreases the level of gamma-aminobutyric acid (GABA). In this 
      paper, we present a case of atypical presentation of SPS with lower limb 
      stiffness misdiagnosed as conversion disorder. CASE PRESENTATION: We report a 
      patient with atypical presentation of SPS with lower limb stiffness and gait 
      disorder misdiagnosed as conversion disorder for a year. Her antithyroid 
      peroxidase antibody (anti-TPO Ab) level was 75 IU (normal value: 0-34 IU). 
      Intravenous immunoglobulin (IVIG) was administered (2gr/kg, 5 days) for the 
      patient that showed significant improvement in the follow-up visit. CONCLUSION: 
      It is essential that in any patient with bizarre gait disorder and suspicious to 
      conversion disorder due to the reversibility of symptoms, SPS and other movement 
      disorder should be considered.
FAU - Razmeh, Saeed
AU  - Razmeh S
AD  - Department of Neurology, Rasoul Akram Hospital, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Habibi, Amir Hasan
AU  - Habibi AH
AD  - Department of Neurology, Rasoul Akram Hospital, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Sina, Farzad
AU  - Sina F
AD  - Department of Neurology, Rasoul Akram Hospital, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Alizadeh, Elham
AU  - Alizadeh E
AD  - Department of Neurology, Rasoul Akram Hospital, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Eslami, Monireh
AU  - Eslami M
AD  - Department of Neurology, Rasoul Akram Hospital, Iran University of Medical 
      Sciences, Tehran, Iran.
LA  - eng
PT  - Case Reports
PL  - Iran
TA  - Caspian J Intern Med
JT  - Caspian journal of internal medicine
JID - 101523876
PMC - PMC5686315
OTO - NOTNLM
OT  - Conversion disorder
OT  - Gait disorder
OT  - Stiff person syndrome
COIS- All the authors declare that there are no competing interests.
EDAT- 2017/12/05 06:00
MHDA- 2017/12/05 06:01
PMCR- 2017/09/01
CRDT- 2017/12/05 06:00
PHST- 2017/12/05 06:00 [entrez]
PHST- 2017/12/05 06:00 [pubmed]
PHST- 2017/12/05 06:01 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - 10.22088/cjim.8.4.329 [doi]
PST - ppublish
SO  - Caspian J Intern Med. 2017 Fall;8(4):329-331. doi: 10.22088/cjim.8.4.329.