PMID- 29201451
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 9
IP  - Suppl 15
DP  - 2017 Nov
TI  - Neuroendocrine tumors of the thymus.
PG  - S1484-S1490
LID - 10.21037/jtd.2017.10.83 [doi]
AB  - Primary neuroendocrine tumors of the thymus (NETTs) are rare and biologically 
      very aggressive neoplasms, usually located in the anterior mediastinal space. 
      They are more frequently observed in males, in their fourth/fifth decades of 
      life. In 50% of cases, NETTs are associated with endocrinopaties [Cushing's 
      syndrome, acromegaly or Multiple Endocrine Neoplasia-1 (MEN-1) syndrome]. NETTs 
      very often present with invasion of the surrounding mediastinal anatomical 
      structures. Surgery, even in advanced stages, is the mainstay of treatment: a 
      compete resection through a median sternotomy or a combined access (sternotomy + 
      thoracotomy) should be always attempted. Induction chemotherapy (+/- radiotherapy) 
      is usually administered in advanced neoplasms, with the aim to achieve tumor 
      shinkage, increasing, therefore, the chance to obtain a complete resection. 
      Postoperative radiotherapy (+/- chemotherapy) is administered in case of invasive 
      lesions, or incomplete resections. NETTs long-term outcome is poor, even in case 
      of completely resected tumors, due to high risk of recurrence or distant 
      metastases development. Prognosis mainly depends on tumor stage, invasivity, 
      completeness of resection, possible association with endocrinopaties and 
      recurrence/distant metastases development.
FAU - Filosso, Pier Luigi
AU  - Filosso PL
AD  - Department of Surgical Sciences, University of Torino, Corso Dogliotti, Torino, 
      Italy.
FAU - Ruffini, Enrico
AU  - Ruffini E
AD  - Department of Surgical Sciences, University of Torino, Corso Dogliotti, Torino, 
      Italy.
FAU - Solidoro, Paolo
AU  - Solidoro P
AD  - San Giovanni Battista Hospital, Service of Pulmonology, Via Genova, Torino, 
      Italy.
FAU - Roffinella, Matteo
AU  - Roffinella M
AD  - Department of Surgical Sciences, University of Torino, Corso Dogliotti, Torino, 
      Italy.
FAU - Lausi, Paolo Olivo
AU  - Lausi PO
AD  - Department of Surgical Sciences, University of Torino, Corso Dogliotti, Torino, 
      Italy.
FAU - Lyberis, Paraskevas
AU  - Lyberis P
AD  - Department of Surgical Sciences, University of Torino, Corso Dogliotti, Torino, 
      Italy.
FAU - Oliaro, Alberto
AU  - Oliaro A
AD  - Department of Surgical Sciences, University of Torino, Corso Dogliotti, Torino, 
      Italy.
FAU - Guerrera, Francesco
AU  - Guerrera F
AD  - Department of Surgical Sciences, University of Torino, Corso Dogliotti, Torino, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC5690945
OTO - NOTNLM
OT  - Thymus
OT  - diagnosis
OT  - neuroendocrine carcinoma
OT  - outcome
OT  - recurrences
OT  - surgery
OT  - symptoms
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2017/12/05 06:00
MHDA- 2017/12/05 06:01
PMCR- 2017/11/01
CRDT- 2017/12/05 06:00
PHST- 2017/12/05 06:00 [entrez]
PHST- 2017/12/05 06:00 [pubmed]
PHST- 2017/12/05 06:01 [medline]
PHST- 2017/11/01 00:00 [pmc-release]
AID - jtd-09-S15-S1484 [pii]
AID - 10.21037/jtd.2017.10.83 [doi]
PST - ppublish
SO  - J Thorac Dis. 2017 Nov;9(Suppl 15):S1484-S1490. doi: 10.21037/jtd.2017.10.83.