PMID- 29202110
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220314
IS  - 2451-9022 (Print)
IS  - 2451-9030 (Electronic)
IS  - 2451-9022 (Linking)
VI  - 2
IP  - 8
DP  - 2017 Nov
TI  - Aberrant Temporal Connectivity in Persons at Clinical High Risk for Psychosis.
PG  - 696-705
LID - 10.1016/j.bpsc.2016.12.008 [doi]
AB  - BACKGROUND: Schizophrenia, a neurodevelopmental disorder, involves abnormalities 
      in functional connectivity (FC) across distributed neural networks, which are 
      thought to antedate the emergence of psychosis. In a cohort of adolescents and 
      young adults at clinical high risk (CHR) for psychosis, we applied data-driven 
      approaches to resting-state fMRI data so as to systematically characterize FC 
      abnormalities during this period and determine whether these abnormalities are 
      associated with psychosis risk and severity of psychotic symptoms. METHODS: 
      Fifty-one CHR participants and 47 matched healthy controls (HCs) were included in 
      our analyses. Twelve of these CHR participants developed psychosis within 3.9 
      years. We estimated one multivariate measure of FC and studied its relationship 
      to CHR status, conversion to psychosis and positive symptom severity. RESULTS: 
      Multivariate analyses revealed between-group differences in whole-brain 
      connectivity patterns of bilateral temporal areas, mostly affecting their 
      functional connections to the thalamus. Further, more severe positive symptoms 
      were associated with greater connectivity abnormalities in the anterior cingulate 
      and frontal cortex. CONCLUSIONS: Our study demonstrates that the well-established 
      FC abnormalities of the thalamus and temporal areas observed in schizophrenia are 
      also present in the CHR period, with aberrant connectivity of the temporal cortex 
      most associated with psychosis risk.
FAU - Colibazzi, Tiziano
AU  - Colibazzi T
AD  - Department of Psychiatry, The New York State Psychiatric Institute, Columbia 
      College of Physicians and Surgeons, New York, NY, USA.
FAU - Yang, Zhen
AU  - Yang Z
AD  - Child Mind Institute, New York, NY, USA.
FAU - Horga, Guillermo
AU  - Horga G
AD  - Department of Psychiatry, The New York State Psychiatric Institute, Columbia 
      College of Physicians and Surgeons, New York, NY, USA.
FAU - Chao-Gan, Yan
AU  - Chao-Gan Y
AD  - Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research 
      Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
FAU - Corcoran, Cheryl M
AU  - Corcoran CM
AD  - Department of Psychiatry, The New York State Psychiatric Institute, Columbia 
      College of Physicians and Surgeons, New York, NY, USA.
FAU - Klahr, Kristin
AU  - Klahr K
AD  - Department of Psychiatry, The New York State Psychiatric Institute, Columbia 
      College of Physicians and Surgeons, New York, NY, USA.
FAU - Brucato, Gary
AU  - Brucato G
AD  - Department of Psychiatry, The New York State Psychiatric Institute, Columbia 
      College of Physicians and Surgeons, New York, NY, USA.
FAU - Girgis, Ragy
AU  - Girgis R
AD  - Department of Psychiatry, The New York State Psychiatric Institute, Columbia 
      College of Physicians and Surgeons, New York, NY, USA.
FAU - Abi-Dargham, Anissa
AU  - Abi-Dargham A
AD  - Department of Psychiatry, The New York State Psychiatric Institute, Columbia 
      College of Physicians and Surgeons, New York, NY, USA.
FAU - Milham, Michael P
AU  - Milham MP
AD  - Child Mind Institute, New York, NY, USA.
FAU - Peterson, Bradley S
AU  - Peterson BS
AD  - Institute for the Developing Mind, Children's Hospital Los Angeles and the Keck 
      School of Medicine, University of Southern California.
LA  - eng
GR  - K23 MH085063/MH/NIMH NIH HHS/United States
GR  - R01 MH107558/MH/NIMH NIH HHS/United States
GR  - T32 MH015144/MH/NIMH NIH HHS/United States
GR  - UL1 TR000040/TR/NCATS NIH HHS/United States
GR  - R21 MH086125/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20170121
PL  - United States
TA  - Biol Psychiatry Cogn Neurosci Neuroimaging
JT  - Biological psychiatry. Cognitive neuroscience and neuroimaging
JID - 101671285
PMC - PMC5708167
MID - NIHMS858026
OTO - NOTNLM
OT  - clinical high-risk
OT  - connectivity
OT  - connectome
OT  - prodrome
OT  - temporal cortex
OT  - thalamus
COIS- Financial Disclosures Dr Girgis has received research support from Otsuka and 
      Genentech. All other authors reported no biomedical financial interests and no 
      potential conflicts of interest.
EDAT- 2017/12/05 06:00
MHDA- 2017/12/05 06:01
PMCR- 2018/11/01
CRDT- 2017/12/05 06:00
PHST- 2017/12/05 06:00 [entrez]
PHST- 2017/12/05 06:00 [pubmed]
PHST- 2017/12/05 06:01 [medline]
PHST- 2018/11/01 00:00 [pmc-release]
AID - 10.1016/j.bpsc.2016.12.008 [doi]
PST - ppublish
SO  - Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Nov;2(8):696-705. doi: 
      10.1016/j.bpsc.2016.12.008. Epub 2017 Jan 21.