PMID- 29202546
OWN - NLM
STAT- MEDLINE
DCOM- 20180529
LR  - 20180529
IS  - 1735-9694 (Electronic)
IS  - 0044-6025 (Linking)
VI  - 55
IP  - 9
DP  - 2017 Sep
TI  - Correlation of Minichromosome Maintenance Protein 6 Expression Rate and Clinical 
      Outcome in Patients With Hodgkin's Lymphoma.
PG  - 550-555
AB  - Minichromosome maintenance complex component 6 (MCM-6) is one of the six proteins 
      of the MCM family, which are involved in the initiation of DNA replication, 
      represents a marker of proliferating cells. The goal of this study was to 
      evaluate the prognostic relevance of the neoplastic cell proliferation rate in 
      patients with Hodgkin's lymphoma (HL). We evaluated the formalin-fixed 
      paraffin-embedded lymph node biopsy specimens from 55 patients by using 
      monoclonal antibody against MCM-6 and compared these findings with clinical data 
      and treatment outcome. Median of MCM-6 expression was 85% (range: 35%-99%). In 
      multivariate analysis, MCM-6 expression, B symptoms, and age were not 
      statistically significant predictor for relapse in contrary to response (P=.001) 
      and stage of disease (P=.048). Patients with lower MCM-6 expression rates showed 
      higher relapse rate and lower disease-free survival (DFS). Meanwhile, patients 
      with MCM-6 expression less than 85% showed shorter DFS (P=.031). We hypothesize 
      that in group of patients with lower MCM-6 expression rate, a larger proportion 
      of proliferating malignant cells are arrested in the very early phase of mitosis, 
      in comparison to the group of patients with higher MCM-6 expression, and this 
      could imply a shorter and probably higher relapse rate in the former group.
FAU - Khodadad, Kian
AU  - Khodadad K
AD  - Department of Internal Medicine, Dalhousie University, Cape Breton Cancer Centre, 
      Sydney, Canada.
FAU - Karimi, Shirin
AU  - Karimi S
AD  - Mycobacteriology Research Center, National Research Institute of Tuberculosis and 
      Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, 
      Iran.
FAU - Esfahani-Monfared, Zahra
AU  - Esfahani-Monfared Z
AD  - Chronic Respiratory Diseases Research Center, National Research Institute of 
      Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Khosravi, Adnan
AU  - Khosravi A
AD  - Chronic Respiratory Diseases Research Center, National Research Institute of 
      Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Bandarchi-Chamkhaleh, Bizhan
AU  - Bandarchi-Chamkhaleh B
AD  - Department of Molecular Pathology, Princess Margaret Hospital, University of 
      Toronto, Toronto, Canada.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Acta Med Iran
JT  - Acta medica Iranica
JID - 14540050R
RN  - 0 (Biomarkers, Tumor)
RN  - EC 3.6.4.12 (MCM6 protein, human)
RN  - EC 3.6.4.12 (Minichromosome Maintenance Complex Component 6)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/analysis
MH  - Cell Proliferation
MH  - Disease-Free Survival
MH  - Female
MH  - Hodgkin Disease/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Minichromosome Maintenance Complex Component 6/*genetics
MH  - Neoplasm Recurrence, Local
MH  - Prognosis
MH  - Young Adult
OTO - NOTNLM
OT  - Hodgkin's disease
OT  - Lymphoma
OT  - Minichromosome maintenance complex component 6 (MCM-6)
EDAT- 2017/12/06 06:00
MHDA- 2018/05/31 06:00
CRDT- 2017/12/06 06:00
PHST- 2017/09/30 00:00 [accepted]
PHST- 2017/12/06 06:00 [entrez]
PHST- 2017/12/06 06:00 [pubmed]
PHST- 2018/05/31 06:00 [medline]
PST - ppublish
SO  - Acta Med Iran. 2017 Sep;55(9):550-555.