PMID- 29202837 OWN - NLM STAT- MEDLINE DCOM- 20180727 LR - 20240327 IS - 1477-7819 (Electronic) IS - 1477-7819 (Linking) VI - 15 IP - 1 DP - 2017 Dec 4 TI - Predictive power of splenic thickness for post-hepatectomy liver failure in HBV-associated hepatocellular carcinoma patients. PG - 216 LID - 10.1186/s12957-017-1281-6 [doi] LID - 216 AB - BACKGROUND: The purpose of this case series is to investigate the relationship between splenic thickness (ST) and postoperative outcomes after hepatic resection in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) patients. METHODS: The clinical data of 320 patients with HBV-associated HCC who had undergone liver resection were retrospectively analyzed. The value of ST in predicting postoperative outcomes was evaluated. RESULTS: A total of 320 patients were enrolled in the study. An increase in ST was significantly associated with an increase in portal vein diameter (PVD), indocyanine green retention rate 15 min (ICG R15), and total bilirubin (TBIL); however, it was negatively correlated with platelet count (PLT). Post-hepatectomy liver failure (PHLF) occurred in 35 (10.9%) patients. Multivariate logistic regression analysis showed that ST was an independent predictor of morbidity and mortality after hepatectomy. Meanwhile, ST was associated with an almost sixfold increased risk for developing perioperative complications (OR 5.678; 95% CI 2.873 to 11.224; P < 0.001) and almost 13-fold increased risk for mortality after hepatectomy (OR 13.007; 95% CI 1.238 to 136.627; P = 0.033).The area under the receiver operating characteristic (ROC) curve (AUC) of ST for predicting the incidence of PHLF was 0.754 (95% confidence interval (CI) 0.667 to 0.841; P < 0.001), with a sensitivity of 57.1% and a specificity of 82.5%, which were significantly greater than those of the ICG R15 level (AUC 0.670; 95% CI 0.560 to 0.779; P < 0.001). The critical value of ST was 43.5 mm. CONCLUSIONS: ST, which is an easy, inexpensive, and routinely available perioperative marker, showed a favorable predictive value for postoperative outcomes in HBV-associated HCC patients. FAU - Chen, Xiang AU - Chen X AD - Department of General Surgery, The Second Xiangya Hospital, Central South University, Renmin Road 139, Changsha, 410011, Hunan, People's Republic of China. FAU - Zou, Heng AU - Zou H AD - Department of General Surgery, The Second Xiangya Hospital, Central South University, Renmin Road 139, Changsha, 410011, Hunan, People's Republic of China. FAU - Xiong, Li AU - Xiong L AD - Department of General Surgery, The Second Xiangya Hospital, Central South University, Renmin Road 139, Changsha, 410011, Hunan, People's Republic of China. FAU - Huang, Sheng-Fu AU - Huang SF AD - Department of General Surgery, The Second Xiangya Hospital, Central South University, Renmin Road 139, Changsha, 410011, Hunan, People's Republic of China. FAU - Miao, Xiong-Ying AU - Miao XY AD - Department of General Surgery, The Second Xiangya Hospital, Central South University, Renmin Road 139, Changsha, 410011, Hunan, People's Republic of China. FAU - Wen, Yu AU - Wen Y AUID- ORCID: 0000-0002-4413-2115 AD - Department of General Surgery, The Second Xiangya Hospital, Central South University, Renmin Road 139, Changsha, 410011, Hunan, People's Republic of China. wenyu2861@csu.edu.cn. LA - eng GR - 2017DK2010/The Key Research and Development Program of Hunan Province/ GR - 81773293/The National Nature Science Foundation of China/ PT - Evaluation Study PT - Journal Article DEP - 20171204 PL - England TA - World J Surg Oncol JT - World journal of surgical oncology JID - 101170544 SB - IM MH - Adult MH - Carcinoma, Hepatocellular/diagnostic imaging/mortality/*surgery/virology MH - Female MH - Hepatectomy/adverse effects MH - Hepatitis B virus/isolation & purification MH - Humans MH - Liver/blood supply/diagnostic imaging/surgery/virology MH - Liver Failure/*epidemiology/etiology MH - Liver Function Tests MH - Liver Neoplasms/diagnostic imaging/mortality/*surgery/virology MH - Male MH - Middle Aged MH - Organ Size MH - Portal Vein/diagnostic imaging MH - Postoperative Complications/*epidemiology/etiology MH - Postoperative Period MH - Predictive Value of Tests MH - Prognosis MH - ROC Curve MH - Retrospective Studies MH - Risk Factors MH - Spleen/diagnostic imaging/*pathology PMC - PMC5716337 OTO - NOTNLM OT - Hepatitis B virus OT - Hepatocellular carcinoma OT - Morbidity OT - Mortality OT - Post-hepatectomy liver failure OT - Splenic thickness COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Ethics approvals were obtained from the ethics committee at Central South University, and written consent of each patient was obtained. CONSENT FOR PUBLICATION: Written informed consent was obtained from the patients for publication of this case series. A copy of the written consent is available for review by the Editor-in-chief of this journal. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2017/12/06 06:00 MHDA- 2018/07/28 06:00 PMCR- 2017/12/04 CRDT- 2017/12/06 06:00 PHST- 2017/07/21 00:00 [received] PHST- 2017/11/20 00:00 [accepted] PHST- 2017/12/06 06:00 [entrez] PHST- 2017/12/06 06:00 [pubmed] PHST- 2018/07/28 06:00 [medline] PHST- 2017/12/04 00:00 [pmc-release] AID - 10.1186/s12957-017-1281-6 [pii] AID - 1281 [pii] AID - 10.1186/s12957-017-1281-6 [doi] PST - epublish SO - World J Surg Oncol. 2017 Dec 4;15(1):216. doi: 10.1186/s12957-017-1281-6.