PMID- 29205667
OWN - NLM
STAT- MEDLINE
DCOM- 20180222
LR  - 20180222
IS  - 1099-0461 (Electronic)
IS  - 1095-6670 (Linking)
VI  - 31
IP  - 12
DP  - 2017 Dec
TI  - The effect of postnatal manganese exposure on the NMDA receptor signaling pathway 
      in rat hippocampus.
LID - 10.1002/jbt.21969 [doi]
AB  - Overexposure to manganese (Mn) is associated with neurological disorders in 
      children. Evidence indicated that N-methyl-d-aspartate (NMDA) receptor signaling 
      pathway was critical for neurobehavioral function. However, whether NMDA receptor 
      signaling pathway contributes to Mn-induced neurotoxicity remains unknown. In 
      this study, newborn Sprague-Dawley rats were randomly assigned to four groups 
      exposed to 0, 10, 20, and 30 mg/kg of Mn(2+) by intraperitoneal injection 
      (n = 10/group: five males and five females). After 3 weeks of Mn exposure, 
      messenger RNA (mRNA) and protein expression of NMDA receptor subunits (NR1, NR2A, 
      and NR2B), cAMP-response element binding protein (CREB), and brain-derived 
      neurotrophic factor (BDNF) in hippocampus were measured by real-time quantitative 
      RT-PCR and Western blot. In Mn-exposed rats, decreased mRNA and protein 
      expression of NR1, NR2A, and NR2B, CREB, and BDNF was observed. The results imply 
      that downregulated NMDA receptor signaling pathway may be of vital importance in 
      the neuropathological process of Mn-induced neurotoxicity.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Wang, Lei
AU  - Wang L
AD  - Department of Developmental and Behavioral Pediatrics, Shanghai Children's 
      Medical Center, Shanghai Jiao Tong University School of Medicine, Ministry of 
      Education Shanghai Key Laboratory of Children's Environmental Health, Shanghai 
      200127, China, Shanghai, 200127, China.
FAU - Fu, HuanHuan
AU  - Fu H
AD  - Department of Hematology and Oncology, Children's Hospital of Fudan University, 
      Shanghai, 201102, China.
FAU - Liu, Bin
AU  - Liu B
AD  - College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 
      350002, China.
FAU - Liu, XiaoYan
AU  - Liu X
AD  - College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 
      350002, China.
FAU - Chen, WeiWei
AU  - Chen W
AD  - Department of Developmental and Behavioral Pediatrics, Shanghai Children's 
      Medical Center, Shanghai Jiao Tong University School of Medicine, Ministry of 
      Education Shanghai Key Laboratory of Children's Environmental Health, Shanghai 
      200127, China, Shanghai, 200127, China.
FAU - Yu, XiaoDan
AU  - Yu X
AUID- ORCID: 0000-0003-2283-7138
AD  - Department of Developmental and Behavioral Pediatrics, Shanghai Children's 
      Medical Center, Shanghai Jiao Tong University School of Medicine, Ministry of 
      Education Shanghai Key Laboratory of Children's Environmental Health, Shanghai 
      200127, China, Shanghai, 200127, China.
LA  - eng
PT  - Journal Article
DEP - 20171204
PL  - United States
TA  - J Biochem Mol Toxicol
JT  - Journal of biochemical and molecular toxicology
JID - 9717231
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 42Z2K6ZL8P (Manganese)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/genetics/metabolism
MH  - Female
MH  - Gene Expression/drug effects
MH  - Hippocampus/drug effects/*metabolism
MH  - Male
MH  - Manganese/*toxicity
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/genetics/*metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - NMDA receptor
OT  - brain-derived neurotrophic factor
OT  - cAMP response element binding
OT  - manganese
OT  - rat hippocampus
EDAT- 2017/12/06 06:00
MHDA- 2018/02/23 06:00
CRDT- 2017/12/06 06:00
PHST- 2017/05/27 00:00 [received]
PHST- 2017/07/14 00:00 [revised]
PHST- 2017/07/20 00:00 [accepted]
PHST- 2017/12/06 06:00 [pubmed]
PHST- 2018/02/23 06:00 [medline]
PHST- 2017/12/06 06:00 [entrez]
AID - 10.1002/jbt.21969 [doi]
PST - ppublish
SO  - J Biochem Mol Toxicol. 2017 Dec;31(12). doi: 10.1002/jbt.21969. Epub 2017 Dec 4.