PMID- 29205876
OWN - NLM
STAT- MEDLINE
DCOM- 20190123
LR  - 20240227
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 62
IP  - 4
DP  - 2018 Feb
TI  - Vitamin D Does Not Play a Functional Role in Adipose Tissue Development in Rodent 
      Models.
LID - 10.1002/mnfr.201700726 [doi]
AB  - SCOPE: Several studies have proposed a role of vitamin D in adipogenesis. Here, 
      we sought to study the impact of the vitamin D receptor (Vdr) on adipocyte size 
      in young and old mice and the effect of maternal vitamin D deficiency on fetal 
      adipogenesis. METHODS AND RESULTS: Histological analysis of adipose tissues shows 
      that Vdr knockout (KO) mice have smaller adipocytes than wild-type (WT) mice. 
      Next, we compare young and old Vdr-KO and WT mice and find no differences in 
      adipocyte sizes between weaned Vdr-KO and WT mice. However, 1-year-old Vdr-KO 
      mice, suffering from alopecia, have smaller-sized adipocytes than WT mice, 
      although they consume more food. To elucidate whether vitamin D can directly 
      impact adipocyte development at a critical stage of adipogenesis, we feed rat 
      dams a vitamin D deficient (0 IU kg(-1) ) or vitamin D adequate (1000 IU kg(-1) ) 
      diet. Neither DNA microarray analysis of the adipose tissues of the newborn rats 
      nor the adipocyte sizes of 21-day-old offspring show significant differences 
      between the two groups. CONCLUSION: Data indicate that vitamin D does not play a 
      fundamental role in adipogenesis because vitamin D does not affect fetal 
      adipogenesis. Moreover, the smaller adipocytes observed in adult Vdr-KO mice are 
      presumably caused by an increased energy expenditure due to alopecia.
CI  - (c) 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Schutkowski, Alexandra
AU  - Schutkowski A
AUID- ORCID: 0000-0002-9387-7869
AD  - Institute of Agricultural and Nutritional Sciences, Martin Luther University 
      Halle-Wittenberg, Halle (Saale), Germany.
FAU - Max, Daniela
AU  - Max D
AD  - Institute of Agricultural and Nutritional Sciences, Martin Luther University 
      Halle-Wittenberg, Halle (Saale), Germany.
FAU - Bonn, Markus
AU  - Bonn M
AD  - Department of Soil Ecology, UFZ Helmholtz Centre for Environmental Research, 
      Halle (Saale), Germany.
AD  - German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, 
      Leipzig, Germany.
FAU - Brandsch, Corinna
AU  - Brandsch C
AD  - Institute of Agricultural and Nutritional Sciences, Martin Luther University 
      Halle-Wittenberg, Halle (Saale), Germany.
FAU - Grundmann, Sarah M
AU  - Grundmann SM
AD  - Institute of Agricultural and Nutritional Sciences, Martin Luther University 
      Halle-Wittenberg, Halle (Saale), Germany.
FAU - Hirche, Frank
AU  - Hirche F
AD  - Institute of Agricultural and Nutritional Sciences, Martin Luther University 
      Halle-Wittenberg, Halle (Saale), Germany.
FAU - Staege, Martin S
AU  - Staege MS
AD  - University Clinic and Polyclinic for Child and Adolescent Medicine, Martin Luther 
      University Halle-Wittenberg, Halle (Saale), Germany.
FAU - Stangl, Gabriele I
AU  - Stangl GI
AD  - Institute of Agricultural and Nutritional Sciences, Martin Luther University 
      Halle-Wittenberg, Halle (Saale), Germany.
AD  - Competence Cluster of Cardiovascular Health and Nutrition (nutriCARD), 
      Halle-Jena-Leipzig, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180112
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (Receptors, Calcitriol)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Animals
MH  - Female
MH  - Male
MH  - Mice
MH  - Rats
MH  - Adipocytes/pathology
MH  - *Adipogenesis
MH  - Energy Metabolism
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Models, Animal
MH  - Rats, Sprague-Dawley
MH  - Receptors, Calcitriol/physiology
MH  - *Vitamin D/physiology
OTO - NOTNLM
OT  - adipocytes
OT  - adipose tissue
OT  - vitamin D
EDAT- 2017/12/06 06:00
MHDA- 2019/01/24 06:00
CRDT- 2017/12/06 06:00
PHST- 2017/08/24 00:00 [received]
PHST- 2017/10/26 00:00 [revised]
PHST- 2017/12/06 06:00 [pubmed]
PHST- 2019/01/24 06:00 [medline]
PHST- 2017/12/06 06:00 [entrez]
AID - 10.1002/mnfr.201700726 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2018 Feb;62(4). doi: 10.1002/mnfr.201700726. Epub 2018 Jan 12.