PMID- 29207002
OWN - NLM
STAT- MEDLINE
DCOM- 20180518
LR  - 20181113
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Print)
IS  - 1462-0324 (Linking)
VI  - 57
IP  - 2
DP  - 2018 Feb 1
TI  - Disability, fatigue, pain and their associates in early diffuse cutaneous 
      systemic sclerosis: the European Scleroderma Observational Study.
PG  - 370-381
LID - 10.1093/rheumatology/kex410 [doi]
AB  - OBJECTIVES: Our aim was to describe the burden of early dcSSc in terms of 
      disability, fatigue and pain in the European Scleroderma Observational Study 
      cohort, and to explore associated clinical features. METHODS: Patients completed 
      questionnaires at study entry, 12 and 24 months, including the HAQ disability 
      index (HAQ-DI), the Cochin Hand Function Scale (CHFS), the Functional Assessment 
      of Chronic Illness Therapy-fatigue and the Short Form 36 (SF36). Associates 
      examined included the modified Rodnan skin score (mRSS), current digital ulcers 
      and internal organ involvement. Correlations between 12-month changes were also 
      examined. RESULTS: The 326 patients recruited (median disease duration 11.9 
      months) displayed high levels of disability [mean (s.d.) HAQ-DI 1.1 (0.83)], with 
      'grip' and 'activity' being most affected. Of the 18 activities assessed in the 
      CHFS, those involving fine finger movements were most affected. High HAQ-DI and 
      CHFS scores were both associated with high mRSS (rho = 0.34, P < 0.0001 and rho = 
      0.35, P < 0.0001, respectively). HAQ-DI was higher in patients with digital 
      ulcers (P = 0.004), pulmonary fibrosis (P = 0.005), cardiac (P = 0.005) and 
      muscle involvement (P = 0.002). As anticipated, HAQ-DI, CHFS, the Functional 
      Assessment of Chronic Illness Therapy and SF36 scores were all highly correlated, 
      in particular the HAQ-DI with the CHFS (rho = 0.84, P < 0.0001). Worsening HAQ-DI 
      over 12 months was strongly associated with increasing mRSS (rho = 0.40, P < 
      0.0001), decreasing hand function (rho = 0.57, P < 0.0001) and increasing fatigue 
      (rho = -0.53, P < 0.0001). CONCLUSION: The European Scleroderma Observational Study 
      highlights the burden of disability in early dcSSc, with high levels of 
      disability and fatigue, associating with the degree of skin thickening (mRSS). 
      Impaired hand function is a major contributor to overall disability.
CI  - (c) The Author 2017. Published by Oxford University Press on behalf of the British 
      Society for Rheumatology. All rights reserved. For Permissions, please email: 
      journals.permissions@oup.com
FAU - Peytrignet, Sebastien
AU  - Peytrignet S
AD  - Centre for Musculoskeletal Research, The University of Manchester, Manchester 
      Academic Health Science Centre, Manchester, UK.
FAU - Denton, Christopher P
AU  - Denton CP
AD  - Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, 
      Royal Free Campus, London, UK.
FAU - Lunt, Mark
AU  - Lunt M
AD  - Centre for Musculoskeletal Research, The University of Manchester, Manchester 
      Academic Health Science Centre, Manchester, UK.
FAU - Hesselstrand, Roger
AU  - Hesselstrand R
AD  - Department of Rheumatology, Lund University, Lund, Sweden.
FAU - Mouthon, Luc
AU  - Mouthon L
AD  - Service de Medecine Interne, Hopital Cochin, Centre de Reference pour les 
      Vascularites Necrosantes et la Sclerodermie Systemique, Universite Paris 
      Descartes, Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France.
FAU - Silman, Alan
AU  - Silman A
AD  - Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, 
      University of Oxford, Oxford, UK.
FAU - Pan, Xiaoyan
AU  - Pan X
AD  - Centre for Musculoskeletal Research, The University of Manchester, Manchester 
      Academic Health Science Centre, Manchester, UK.
FAU - Brown, Edith
AU  - Brown E
AD  - Centre for Musculoskeletal Research, The University of Manchester, Manchester 
      Academic Health Science Centre, Manchester, UK.
FAU - Czirjak, Laszlo
AU  - Czirjak L
AD  - Department of Rheumatology and Immunology, Medical Center, University of Pecs, 
      Pecs, Hungary, Erlangen, Germany.
FAU - Distler, Jorg H W
AU  - Distler JHW
AD  - Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, 
      Germany.
FAU - Distler, Oliver
AU  - Distler O
AD  - Department of Rheumatology, University of Zurich, Zurich, Switzerland.
FAU - Fligelstone, Kim
AU  - Fligelstone K
AD  - Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, 
      Royal Free Campus, London, UK.
FAU - Gregory, William J
AU  - Gregory WJ
AD  - Rehabilitation Services, Salford Royal NHS Foundation Trust, Salford, UK.
FAU - Ochiel, Rachel
AU  - Ochiel R
AD  - Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, 
      Royal Free Campus, London, UK.
FAU - Vonk, Madelon
AU  - Vonk M
AD  - Department of the Rheumatic Diseases, Radboud University Nijmegen Medical Centre, 
      Nijmegen, The Netherlands.
FAU - Ancuta, Codrina
AU  - Ancuta C
AD  - Rheumatology 2 Department, Clinical Rehabilitation Hospital, 'Grigore T. Popa' 
      University of Medicine and Pharmacy, Iasi, Romania.
FAU - Ong, Voon H
AU  - Ong VH
AD  - Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, 
      Royal Free Campus, London, UK.
FAU - Farge, Dominique
AU  - Farge D
AD  - Unite Clinique de Medecine Interne, Maladies Auto-immunes et Pathologie 
      Vasculaire, Hopital Saint-Louis, Paris, France.
FAU - Hudson, Marie
AU  - Hudson M
AD  - Lady Davis Institute, Jewish General Hospital, Montreal, Canada.
AD  - Department of Medicine, McGill University, Montreal, Canada.
FAU - Matucci-Cerinic, Marco
AU  - Matucci-Cerinic M
AD  - Department Experimental and Clinical Medicine, Division Rheumatology AOUC, 
      University of Florence, Florence, Italy.
FAU - Balbir-Gurman, Alexandra
AU  - Balbir-Gurman A
AD  - B. Shine Rheumatology Unit, Rambam Heath Care Campus, Rappaport Faculty of 
      Medicine, Technion, Haifa, Israel.
FAU - Midtvedt, Oyvind
AU  - Midtvedt O
AD  - Rheumatology Unit, Oslo University Hospital Rikshospitalet, Oslo, Norway.
FAU - Jordan, Alison C
AU  - Jordan AC
AD  - Queen Elizabeth Hospital Birmingham, UHB Foundation Trust, Birmingham, UK.
FAU - Stevens, Wendy
AU  - Stevens W
AD  - Rheumatology Unit, St Vincent's Hospital, Melbourne, Australia.
FAU - Moinzadeh, Pia
AU  - Moinzadeh P
AD  - Department for Dermatology, University of Cologne, Koln, Germany.
FAU - Hall, Frances C
AU  - Hall FC
AD  - Department of Clinical Medicine, Cambridge University NHS Hospital Foundation 
      Trust, Cambridge, UK.
FAU - Agard, Christian
AU  - Agard C
AD  - Department of Internal Medicine, Hotel-Dieu Hospital, University of Nantes, 
      Nantes, France.
FAU - Anderson, Marina E
AU  - Anderson ME
AD  - University of Liverpool, Aintree University Hospital, Liverpool, UK.
FAU - Diot, Elisabeth
AU  - Diot E
AD  - Service de Medecine Interne, Hopital Bretonneau Tours, Tours, France.
FAU - Madhok, Rajan
AU  - Madhok R
AD  - Centre for Rheumatic Diseases, Royal Infirmary, Glasgow, UK.
FAU - Akil, Mohammed
AU  - Akil M
AD  - Department of Rheumatology, Sheffield Teaching Hospitals, Sheffield, UK.
FAU - Buch, Maya H
AU  - Buch MH
AD  - Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 
      Leeds, UK.
AD  - NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS 
      Trust, Leeds, UK.
FAU - Chung, Lorinda
AU  - Chung L
AD  - Division of Immunology and Rheumatology, Stanford University, Stanford, CA, USA.
FAU - Damjanov, Nemanja
AU  - Damjanov N
AD  - Institute of Rheumatology, University of Belgrade School of Medicine, Belgrade, 
      Serbia.
FAU - Gunawardena, Harsha
AU  - Gunawardena H
AD  - Clinical and Academic Rheumatology, North Bristol NHS Trust, Bristol, UK.
FAU - Lanyon, Peter
AU  - Lanyon P
AD  - Rheumatology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
AD  - Rheumatology, Nottingham NHS Treatment Centre, Nottingham, UK.
FAU - Ahmad, Yasmeen
AU  - Ahmad Y
AD  - Peter Maddison Rheumatology Centre, Llandudno Hospital, Llandudno, UK.
FAU - Chakravarty, Kuntal
AU  - Chakravarty K
AD  - Department of Rheumatology, Queen's Hospital, Romford, UK.
FAU - Jacobsen, Soren
AU  - Jacobsen S
AD  - Copenhagen Lupus and Vasculitis Clinic, Center for Rheumatology and Spine 
      Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
FAU - MacGregor, Alexander J
AU  - MacGregor AJ
AD  - Department of Medicine, Norwich Medical School, University of East Anglia, 
      Norwich, UK.
FAU - McHugh, Neil
AU  - McHugh N
AD  - Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, 
      UK.
FAU - Muller-Ladner, Ulf
AU  - Muller-Ladner U
AD  - Department of Rheumatology and Clinical Immunology, Justus-Liebig University 
      Giessen, Kerckhoff Klinik, Bad Nauheim, Germany.
FAU - Riemekasten, Gabriela
AU  - Riemekasten G
AD  - Department of Rheumatology, University of Lubeck, Lubeck, Berlin, Germany.
FAU - Becker, Michael
AU  - Becker M
AD  - Department of Rheumatology and Clinical Immunology, University Hospital Charite 
      Berlin, Berlin, Germany.
FAU - Roddy, Janet
AU  - Roddy J
AD  - Department of Rheumatology, Royal Perth Hospital, Perth, Australia.
FAU - Carreira, Patricia E
AU  - Carreira PE
AD  - Servicio de Reumatologia, Hospital Universitario 12 de Octubre, Madrid, Spain.
FAU - Fauchais, Anne Laure
AU  - Fauchais AL
AD  - Internal Medicine Unit, Limoges University Hospital, Limoges, France.
FAU - Hachulla, Eric
AU  - Hachulla E
AD  - Centre National de Reference Maladies Systemiques et Auto-immunes Rares, 
      Departement de Medecine Interne et Immunologie Clinique, Universite de Lille, 
      Lille, France.
FAU - Hamilton, Jennifer
AU  - Hamilton J
AD  - Department of Rheumatology, Gateshead Hospitals Foundation Trust, Gateshead, UK.
FAU - Inanc, Murat
AU  - Inanc M
AD  - Department of Internal Medicine, Division of Rheumatology, Istanbul Medical 
      Faculty, Istanbul University, Istanbul, Turkey.
FAU - McLaren, John S
AU  - McLaren JS
AD  - Fife Rheumatic Diseases Unit, Whyteman's Brae Hospital, Kirkcaldy, Scotland, UK.
FAU - van Laar, Jacob M
AU  - van Laar JM
AD  - Department of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, the 
      Netherlands.
FAU - Pathare, Sanjay
AU  - Pathare S
AD  - Rheumatology, James Cook University Hospital, Middlesbrough, UK.
FAU - Proudman, Susanna
AU  - Proudman S
AD  - Rheumatology Unit, Royal Adelaide Hospital.
AD  - Discipline of Medicine, University of Adelaide, Adelaide, Australia.
FAU - Rudin, Anna
AU  - Rudin A
AD  - Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at 
      Gothenburg University, Gothenburg, Sweden.
FAU - Sahhar, Joanne
AU  - Sahhar J
AD  - Monash Centre for Inflammatory Diseases, Monash University, Melbourne, Australia.
FAU - Coppere, Brigitte
AU  - Coppere B
AD  - Department of Internal Medicine, Hopital Edouard Herriot, Lyon, France.
FAU - Serratrice, Christine
AU  - Serratrice C
AD  - Department of Internal Medicine, Foundation Hospital Saint Joseph, Marseille, 
      France.
FAU - Sheeran, Tom
AU  - Sheeran T
AD  - Department of Rheumatology, Cannock Chase Hospital, Cannock, UK.
FAU - Veale, Douglas J
AU  - Veale DJ
AD  - Rheumatology, St Vincent's University Hospital, Dublin, Ireland.
FAU - Grange, Claire
AU  - Grange C
AD  - Department of Internal Medicine 69310, Centre Hospitalier Lyon Sud, 
      Pierre-Benite, Lyon, France.
FAU - Trad, Georges-Selim
AU  - Trad GS
AD  - Internal Medecine, Ambroise Pare Hospital, Boulogne, Billancourt, France.
FAU - Herrick, Ariane L
AU  - Herrick AL
AD  - Centre for Musculoskeletal Research, The University of Manchester, Manchester 
      Academic Health Science Centre, Manchester, UK.
AD  - Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, 
      Manchester, UK.
AD  - NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS 
      Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
SB  - IM
MH  - Adult
MH  - Cost of Illness
MH  - *Disability Evaluation
MH  - Europe
MH  - Fatigue/etiology/*physiopathology
MH  - Female
MH  - Fingers
MH  - Hand Strength
MH  - Health Surveys
MH  - Humans
MH  - Male
MH  - Pain/etiology/*physiopathology
MH  - Prospective Studies
MH  - Scleroderma, Diffuse/complications/*physiopathology
MH  - *Severity of Illness Index
MH  - Skin Ulcer/etiology/physiopathology
PMC - PMC5850714
OTO - NOTNLM
OT  - disability
OT  - early diffuse cutaneous systemic sclerosis
OT  - fatigue
OT  - hand function
OT  - pain
EDAT- 2017/12/06 06:00
MHDA- 2018/05/19 06:00
PMCR- 2017/11/30
CRDT- 2017/12/06 06:00
PHST- 2017/01/30 00:00 [received]
PHST- 2017/12/06 06:00 [pubmed]
PHST- 2018/05/19 06:00 [medline]
PHST- 2017/12/06 06:00 [entrez]
PHST- 2017/11/30 00:00 [pmc-release]
AID - 4675178 [pii]
AID - kex410 [pii]
AID - 10.1093/rheumatology/kex410 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2018 Feb 1;57(2):370-381. doi: 
      10.1093/rheumatology/kex410.