PMID- 29207308
OWN - NLM
STAT- MEDLINE
DCOM- 20190130
LR  - 20190130
IS  - 1879-0364 (Electronic)
IS  - 1369-5274 (Linking)
VI  - 43
DP  - 2018 Jun
TI  - Road MAPs to engineer host microbiomes.
PG  - 46-54
LID - S1369-5274(17)30195-9 [pii]
LID - 10.1016/j.mib.2017.11.023 [doi]
AB  - Microbiomes contribute directly or indirectly to host health and fitness. Thus 
      far, investigations into these emergent traits, referred to here as 
      microbiome-associated phenotypes (MAPs), have been primarily qualitative and 
      taxonomy-driven rather than quantitative and trait-based. We present the 
      MAPs-first approach, a theoretical and experimental roadmap that involves 
      quantitative profiling of MAPs across genetically variable hosts and subsequent 
      identification of the underlying mechanisms. We outline strategies for developing 
      'modular microbiomes'-synthetic microbial consortia that are engineered in 
      concert with the host genotype to confer different but mutually compatible MAPs 
      to a single host or host population. By integrating host and microbial traits, 
      these strategies will facilitate targeted engineering of microbiomes to the 
      benefit of agriculture, human/animal health and biotechnology.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Oyserman, Ben O
AU  - Oyserman BO
AD  - Bioinformatics Group, Wageningen University, Wageningen, Netherlands; Department 
      of Microbial Ecology, Netherlands Institute of Ecology (NIOO/KNAW), Wageningen, 
      Netherlands.
FAU - Medema, Marnix H
AU  - Medema MH
AD  - Bioinformatics Group, Wageningen University, Wageningen, Netherlands.
FAU - Raaijmakers, Jos M
AU  - Raaijmakers JM
AD  - Department of Microbial Ecology, Netherlands Institute of Ecology (NIOO/KNAW), 
      Wageningen, Netherlands; Institute of Biology, Leiden University, Wageningen, 
      Netherlands. Electronic address: j.raaijmakers@nioo.knaw.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20171205
PL  - England
TA  - Curr Opin Microbiol
JT  - Current opinion in microbiology
JID - 9815056
SB  - IM
MH  - Animals
MH  - Genetic Engineering/*methods
MH  - Host Microbial Interactions/*genetics
MH  - Humans
MH  - Microbial Consortia/*genetics
MH  - Microbiota/genetics
MH  - Phenotype
MH  - Probiotics
EDAT- 2017/12/06 06:00
MHDA- 2019/01/31 06:00
CRDT- 2017/12/06 06:00
PHST- 2017/10/19 00:00 [received]
PHST- 2017/11/20 00:00 [revised]
PHST- 2017/11/21 00:00 [accepted]
PHST- 2017/12/06 06:00 [pubmed]
PHST- 2019/01/31 06:00 [medline]
PHST- 2017/12/06 06:00 [entrez]
AID - S1369-5274(17)30195-9 [pii]
AID - 10.1016/j.mib.2017.11.023 [doi]
PST - ppublish
SO  - Curr Opin Microbiol. 2018 Jun;43:46-54. doi: 10.1016/j.mib.2017.11.023. Epub 2017 
      Dec 5.