PMID- 29207384
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20190215
IS  - 1423-0259 (Electronic)
IS  - 0030-3747 (Linking)
VI  - 61
IP  - 1
DP  - 2019
TI  - SLC2A1 Tag SNPs in Greek Patients with Diabetic Retinopathy and Nephropathy.
PG  - 26-35
LID - 10.1159/000480241 [doi]
AB  - Backround: Genetic variants are implicated in the development of diabetic 
      retinopathy (DR) and nephropathy (DN). The role of solute carrier family 
      2-facilitated glucose transporter member 1 (SLC2A1), also known as glucose 
      transporter (GLUT1), on DR and DN remain controversial. OBJECTIVE: Examination of 
      the influence of tag SLC2A1 single-nucleotide polymorphisms (SNPs) on the 
      development of DR and DN during the course of type 2 diabetes mellitus (T2DM). 
      METHODS: A total of 169 patients with DR or DN, 107 uncomplicated T2DM patients, 
      and 315 controls were recruited and genotyped for 14 SLC2A1 tag SNPs. SNPs and 
      haplotypes were tested for associations with microvascular diabetes' 
      complications. RESULTS: rs3768029 TT genotype was associated with a lower risk of 
      DR + DN, compared to the CC wild-type (p = 0.0024). Moreover, CT and TT rs841847 
      genotypes were associated with a higher risk of DR + DN compared to the CC 
      genotype (p = 0.0028). A common haplotype (GGCCCGCATCAAT) was associated with an 
      increased risk of DR, DN, DR +/- DN, and DR + DN phenotypes. Mutational loads of 
      rs3768029, rs3729548, rs841853, and rs841847 were found to influence the 
      development of microvascular complications during the T2DM course. CONCLUSIONS: 
      This study provides evidence that SLC2A1 gene variants might be implicated in the 
      development of T2DM microvascular complications.
CI  - (c) 2017 S. Karger AG, Basel.
FAU - Siokas, Vasileios
AU  - Siokas V
AD  - Laboratory of Neurogenetics, Department of Neurology, University Hospital of 
      Larissa, Larissa, Greece.
FAU - Fotiadou, Anatoli
AU  - Fotiadou A
FAU - Dardiotis, Efthimios
AU  - Dardiotis E
FAU - Kotoula, Maria G
AU  - Kotoula MG
FAU - Tachmitzi, Sophia V
AU  - Tachmitzi SV
FAU - Chatzoulis, Dimitrios Z
AU  - Chatzoulis DZ
FAU - Zintzaras, Elias
AU  - Zintzaras E
FAU - Stefanidis, Ioannis
AU  - Stefanidis I
FAU - Tsironi, Evangelia E
AU  - Tsironi EE
LA  - eng
PT  - Journal Article
DEP - 20171206
PL  - Switzerland
TA  - Ophthalmic Res
JT  - Ophthalmic research
JID - 0267442
RN  - 0 (Glucose Transporter Type 1)
RN  - 0 (SLC2A1 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Retinopathy/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - Genotype
MH  - Glucose Transporter Type 1/*genetics
MH  - Greece
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Diabetes type 2
OT  - Diabetic nephropathy
OT  - Diabetic retinopathy
OT  - SLC2A1
OT  - Tag single nucleotide polymorphisms
EDAT- 2017/12/06 06:00
MHDA- 2019/02/12 06:00
CRDT- 2017/12/06 06:00
PHST- 2017/01/18 00:00 [received]
PHST- 2017/08/10 00:00 [accepted]
PHST- 2017/12/06 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
PHST- 2017/12/06 06:00 [entrez]
AID - 000480241 [pii]
AID - 10.1159/000480241 [doi]
PST - ppublish
SO  - Ophthalmic Res. 2019;61(1):26-35. doi: 10.1159/000480241. Epub 2017 Dec 6.