PMID- 29207691
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 2249-782X (Print)
IS  - 0973-709X (Electronic)
IS  - 0973-709X (Linking)
VI  - 11
IP  - 9
DP  - 2017 Sep
TI  - A Comparative Study of High Sensitivity C-Reactive Protein and Metabolic 
      Variables in Type 2 Diabetes Mellitus with and without Nephropathy.
PG  - BC01-BC04
LID - 10.7860/JCDR/2017/30272.10528 [doi]
AB  - INTRODUCTION: Diabetic nephropathy is a serious chronic complication of Type 2 
      Diabetes Mellitus (T2DM) which impairs the quality of life, leading to increased 
      morbidity and mortality. The high sensitivity C-reactive protein (hs-CRP) is an 
      acute phase reactant which acts as a non-specific systemic marker of 
      inflammation. AIM: To find out the relationship between serum hs-CRP and 
      metabolic variables in Type 2 diabetic patients with and without nephropathy. 
      MATERIALS AND METHODS: The study group consists of 96 subjects that include 
      non-diabetic healthy controls, Type 2 diabetic patients without any complications 
      and patients with diabetic nephropathy. The study group was composed of both 
      genders, aged 31-70 years, who reported after 10-12 hours overnight fasting; 
      then, venous blood and fresh urine samples were collected, in the morning from 
      all the study subjects. Data were analysed using Statistical Package for the 
      Social Sciences (SPSS). Independent t-test was used to compare between the groups 
      and Chi square test was used to find out the relationship between serum hs-CRP 
      and metabolic variables. RESULTS: The results showed a significantly (p<0.05) 
      increasing trend of serum hs-CRP with the degree of microalbumin excretion and 
      the severity of nephropathy in Type 2 diabetic patients. The result showed a 
      significant (p<0.05) relationship between hs-CRP and the metabolic variables like 
      Fasting Blood Glucose (FBG), Post Prandial Blood Glucose (PPBG), Total 
      Cholesterol (TC), Triglycerides (TG), LDL-Cholesterol (LDL-C), TC:HDL-Cholesterol 
      (HDL-C) ratio and estimated Glomerular Filtration Rate (eGFR) and no significance 
      (p>0.05) between hs-CRP and HDL-Cholesterol in both diabetic and diabetic 
      nephropathy subjects. CONCLUSION: Hs-CRP was strongly associated with the 
      metabolic variables and predictors of cardiovascular risk in Type 2 diabetes 
      mellitus with and without nephropathy. The hs-CRP might be considered as a 
      predictor or illness indicator for the development of nephropathy and 
      cardiovascular risk in Type 2 diabetic patients.
FAU - Shaheer, Abid K
AU  - Shaheer AK
AD  - Postgraduate Student, Department of Biochemistry, School of Health Sciences, 
      University of Calicut, Malappuram, Kerala, India.
FAU - Tharayil, Jithesh K
AU  - Tharayil JK
AD  - Associate Professor, Department of Biochemistry, MES Medical College, 
      Perinthalmanna, Kerala, India.
FAU - Krishna, Parvathi W
AU  - Krishna PW
AD  - Professor and Head, Department of Biochemistry, MES Medical College, 
      Perinthalmanna, Kerala, India.
LA  - eng
PT  - Journal Article
DEP - 20170901
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC5713713
OTO - NOTNLM
OT  - Dyslipidemia
OT  - Hyperglycemia
OT  - Inflammation
OT  - Insulin resistance
EDAT- 2017/12/07 06:00
MHDA- 2017/12/07 06:01
PMCR- 2017/09/01
CRDT- 2017/12/07 06:00
PHST- 2017/05/21 00:00 [received]
PHST- 2017/08/08 00:00 [accepted]
PHST- 2017/12/07 06:00 [entrez]
PHST- 2017/12/07 06:00 [pubmed]
PHST- 2017/12/07 06:01 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - 10.7860/JCDR/2017/30272.10528 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2017 Sep;11(9):BC01-BC04. doi: 10.7860/JCDR/2017/30272.10528. 
      Epub 2017 Sep 1.