PMID- 29207943 OWN - NLM STAT- MEDLINE DCOM- 20180702 LR - 20191210 IS - 1471-2261 (Electronic) IS - 1471-2261 (Linking) VI - 17 IP - 1 DP - 2017 Dec 6 TI - Auxiliary diagnostic potential of ventricle geometry and late gadolinium enhancement in left ventricular non-compaction; non-randomized case control study. PG - 286 LID - 10.1186/s12872-017-0721-0 [doi] LID - 286 AB - BACKGROUND: There are still ambiguities existing in regard to left ventricular non-compaction (LVNC) diagnostic imaging. The aim of our study was to analyze diagnostic potential of late gadolinium enhancement (LGE) and ventricle geometry in patients with LVNC and controls. METHODS: Data on cardiac magnetic resonance imaging (CMR) studies for LVNC were reassessed from the hospital's database (3.75 years; n=1975 exams). Matching sample of controls included cases with no structural heart disease, hypertrophic or dilative cardiomyopathy, arrhythmogenic right ventricular dysplasia or subacute myocarditis. Eccentricity of the left ventricle was measured at end diastole in the region with pronounced NC and maximal to minimal ratio (MaxMinEDDR) was calculated. RESULTS: Study included 255 patients referred for CMR, 100 (39.2%) with LVNC (prevalence in the studied period 5.01%) and 155 (60.8%) controls. Existing LGE had sensitivity of 52.5% (95%-CI:42.3-62.5), specificity of 80.4% (95%-CI:73.2-86.5) for LVNC, area under curve (AUC) 0.664 (95%-CI:0.603-0.722);p<0.001. MaxMinEDDR>1.10 had sensitivity of 95.0% (95%-CI:88.7-98.4), specificity of 82.6% (95%-CI: 75.7-88.2) for LVNC, AUC 0.917 (95%-CI:0.876-0.948); p<0.001. LGE correlated with Max-Min-EDD-R (Rho=0.130; p=0.038) and there was significant difference in ROC analysis DeltaAUC0.244 (95%-CI:0.175-0.314); p<0.001. LGE also correlated negatively with stroke volume and systolic function (both p<0.05, respectively). CONCLUSIONS: LGE was found to be frequently expressed in patients with LVNC, but without sufficient power to be used as a discriminative diagnostic parameter. Both LGE and eccentricity of the left ventricle were found to be relatively solid diagnostic landmarks of complex infrastructural and functional changes within the failing heart. FAU - Boban, Marko AU - Boban M AUID- ORCID: 0000-0002-6129-575X AD - Department of Cardiology, University hospital "Thalassotherapia Opatija", Faculty of Medicine, University of Rijeka, M. Tita 188/1, 51 440, Opatija, Croatia. marcoboban@yahoo.com. AD - Department of Internal medicine, Faculty of Medicine, "J.J. Strossmayer" University of Osijek, Osijek, Croatia. marcoboban@yahoo.com. FAU - Pesa, Vladimir AU - Pesa V AD - Department of Cardiology, University hospital "Thalassotherapia Opatija", Faculty of Medicine, University of Rijeka, M. Tita 188/1, 51 440, Opatija, Croatia. FAU - Gabric, Ivo Darko AU - Gabric ID AD - Department of Cardiology, University Hospital "Sestre Milosrdnice" Zagreb, Zagreb, Croatia. FAU - Manola, Sime AU - Manola S AD - Department of Cardiology, University Hospital "Sestre Milosrdnice" Zagreb, Zagreb, Croatia. FAU - Persic, Viktor AU - Persic V AD - Department of Cardiology, University hospital "Thalassotherapia Opatija", Faculty of Medicine, University of Rijeka, M. Tita 188/1, 51 440, Opatija, Croatia. AD - Department of Internal medicine, Faculty of Medicine, "J.J. Strossmayer" University of Osijek, Osijek, Croatia. FAU - Antic-Kauzlaric, Helena AU - Antic-Kauzlaric H AD - Department of Cardiology, University hospital "Thalassotherapia Opatija", Faculty of Medicine, University of Rijeka, M. Tita 188/1, 51 440, Opatija, Croatia. FAU - Zulj, Marinko AU - Zulj M AD - Department of Internal medicine, Faculty of Medicine, "J.J. Strossmayer" University of Osijek, Osijek, Croatia. FAU - Vcev, Aleksandar AU - Vcev A AD - Department of Internal medicine, Faculty of Medicine, "J.J. Strossmayer" University of Osijek, Osijek, Croatia. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20171206 PL - England TA - BMC Cardiovasc Disord JT - BMC cardiovascular disorders JID - 100968539 RN - 0 (Contrast Media) RN - 84F6U3J2R6 (gadodiamide) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Adult MH - Area Under Curve MH - Contrast Media/*administration & dosage MH - Female MH - Gadolinium DTPA/*administration & dosage MH - Heart Ventricles/abnormalities/*diagnostic imaging/physiopathology MH - Humans MH - Isolated Noncompaction of the Ventricular Myocardium/*diagnostic imaging/physiopathology MH - *Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Predictive Value of Tests MH - Prognosis MH - ROC Curve MH - Registries MH - Reproducibility of Results MH - Retrospective Studies MH - Stroke Volume MH - Ventricular Function, Left PMC - PMC5718034 OTO - NOTNLM OT - Cardiac magnetic resonance imaging (CMR) OT - Late gadolinium enhancement (LGE) OT - Left ventricle non-compaction (LVNC) OT - Left ventricular geometry COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: This study was conducted in Thalassotherapia Opatija University hospital, associated with the Faculty of Medicine of the University of Rijeka and Faculty of Medicine of the University of Osijek. It was approved by the ethical committee of the Hospital. Patients were included after signing of an informed consent form. Study was conducted in accordance with the Declaration of Helsinki and good clinical practice principles. CONSENT FOR PUBLICATION: Not applicable COMPETING INTERESTS: The authors declare they have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2017/12/07 06:00 MHDA- 2018/07/03 06:00 PMCR- 2017/12/06 CRDT- 2017/12/07 06:00 PHST- 2017/08/26 00:00 [received] PHST- 2017/11/27 00:00 [accepted] PHST- 2017/12/07 06:00 [entrez] PHST- 2017/12/07 06:00 [pubmed] PHST- 2018/07/03 06:00 [medline] PHST- 2017/12/06 00:00 [pmc-release] AID - 10.1186/s12872-017-0721-0 [pii] AID - 721 [pii] AID - 10.1186/s12872-017-0721-0 [doi] PST - epublish SO - BMC Cardiovasc Disord. 2017 Dec 6;17(1):286. doi: 10.1186/s12872-017-0721-0.