PMID- 29208176
OWN - NLM
STAT- MEDLINE
DCOM- 20180717
LR  - 20181023
IS  - 1165-158X (Electronic)
IS  - 0145-5680 (Linking)
VI  - 63
IP  - 11
DP  - 2017 Nov 30
TI  - Analysis of potential interactions between vitamins D and C using gene expression 
      profiles from mouse models.
PG  - 68-74
LID - 10.14715/cmb/2017.63.11.13 [doi]
AB  - Vitamin D (VD) and vitamin C (VC) have been recognized as essential elements for 
      human health.  Animal models, especially mouse models, have been widely used in 
      the study of VD and VC. This study is to investigate how VD and VC interact at 
      molecular level using whole genome expression profiles from spleens of 111 mouse 
      strains and livers from 40 mouse strains. We first identified the genes that are 
      closely correlated to vitamin D receptor (Vdr) and gulonolactone oxidase (Lgo). 
      We next analyzed the potential molecular pathways of Vdrand Lgo correlated genes 
      and examined how these two sets of pathways are connected in liver and spleen. 
      Our results indicated that Vdrand Lgo associate to distinct groups of genes. 
      While most of genes are not the same, a few of them are associated to both Vdrand 
      Lgo.  Our gene network construction suggests that there are interactions between 
      Vdrand Lgopathways.  Our work laid down the foundation for future study of the 
      interactions between VD and VC and revealed the potential bias when using animals 
      for the study of VD or VC, as humans do not produce VC.
FAU - Jiao, Yan
AU  - Jiao Y
AD  - Mudanjiang Medical College, Mudanjiang, 157001, HeilongJiang, PR China.
FAU - Niu, Mingming
AU  - Niu M
AD  - Department of Orthopedic Surgery and BME, University of Tennessee Health Science 
      Center, Memphis, TN, 38163, USA.
FAU - Tian, Cheng
AU  - Tian C
AD  - Department of Orthopedic Surgery and BME, University of Tennessee Health Science 
      Center, Memphis, TN, 38163, USA.
FAU - Yan, Jian
AU  - Yan J
AD  - Department of Orthopedic Surgery and BME, University of Tennessee Health Science 
      Center, Memphis, TN, 38163, USA.
FAU - Vancil, Aron W
AU  - Vancil AW
AD  - Department of Biology, Rhodes College, 2000 N. Parkway, Memphis, TN 38112, USA.
FAU - Yan, Xuenan
AU  - Yan X
AD  - Department of Science, University of Tennessee, Knoxville, TN 37996, USA.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Intergrative Research Center, The first hospital affilliated to Heilongjiang 
      University of Traditional Chinese Medicine.
LA  - eng
PT  - Journal Article
DEP - 20171130
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (Receptors, Calcitriol)
RN  - 1406-16-2 (Vitamin D)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Animals
MH  - Ascorbic Acid/*metabolism
MH  - Liver/metabolism
MH  - Mice
MH  - Receptors, Calcitriol/genetics
MH  - Spleen/metabolism
MH  - Vitamin D/*metabolism
OTO - NOTNLM
OT  - Gene Expression
OT  - Mouse
OT  - Network
OT  - Vitamin C
OT  - Vitamin D.
EDAT- 2017/12/07 06:00
MHDA- 2018/07/18 06:00
CRDT- 2017/12/07 06:00
PHST- 2017/04/18 00:00 [received]
PHST- 2017/10/20 00:00 [accepted]
PHST- 2017/12/07 06:00 [entrez]
PHST- 2017/12/07 06:00 [pubmed]
PHST- 2018/07/18 06:00 [medline]
AID - 10.14715/cmb/2017.63.11.13 [doi]
PST - epublish
SO  - Cell Mol Biol (Noisy-le-grand). 2017 Nov 30;63(11):68-74. doi: 
      10.14715/cmb/2017.63.11.13.