PMID- 29209238
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 8
DP  - 2017
TI  - Disrupted Control-Related Functional Brain Networks in Drug-Naive Children with 
      Attention-Deficit/Hyperactivity Disorder.
PG  - 246
LID - 10.3389/fpsyt.2017.00246 [doi]
LID - 246
AB  - Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental 
      disease featuring executive control deficits as a prominent neuropsychological 
      trait. Executive functions are implicated in multiple sub-networks of the brain; 
      however, few studies examine these sub-networks as a whole in ADHD. By combining 
      resting-state functional MRI and graph-based approaches, we systematically 
      investigated functional connectivity patterns among four control-related 
      networks, including the frontoparietal network (FPN), cingulo-opercular network, 
      cerebellar network, and default mode network (DMN), in 46 drug-naive children 
      with ADHD and 31 age-, gender-, and intelligence quotient-matched healthy 
      controls (HCs). Compared to the HCs, the ADHD children showed significantly 
      decreased functional connectivity that primarily involved the DMN and FPN regions 
      and cross-network long-range connections. Further graph-based network analysis 
      revealed that the ADHD children had fewer connections, lower network efficiency, 
      and more functional modules compared with the HCs. The ADHD-related alterations 
      in functional connectivity but not topological organization were correlated with 
      clinical symptoms of the ADHD children and differentiated the patients from the 
      HCs with a good performance. Taken together, our findings suggest a 
      less-integrated functional brain network in children with ADHD due to selective 
      disruption of key long-range connections, with important implications for 
      understanding the neural substrates of ADHD, particularly executive dysfunction.
FAU - Tao, Jiejie
AU  - Tao J
AD  - Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, 
      Wenzhou Medical University, Wenzhou, China.
FAU - Jiang, Xueyan
AU  - Jiang X
AD  - Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, 
      China.
AD  - Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, 
      Hangzhou, China.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Radiology, Yancheng First Peoples' Hospital, Yancheng, China.
FAU - Liu, Huiru
AU  - Liu H
AD  - Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, 
      Wenzhou Medical University, Wenzhou, China.
FAU - Qian, Andan
AU  - Qian A
AD  - Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, 
      Wenzhou Medical University, Wenzhou, China.
FAU - Yang, Chuang
AU  - Yang C
AD  - Department of Psychiatry, First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou Medical University, Wenzhou, China.
FAU - Chen, Hong
AU  - Chen H
AD  - Department of Psychiatry, First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou Medical University, Wenzhou, China.
FAU - Li, Jiance
AU  - Li J
AD  - Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, 
      Wenzhou Medical University, Wenzhou, China.
FAU - Ye, Qiong
AU  - Ye Q
AD  - Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, 
      Wenzhou Medical University, Wenzhou, China.
FAU - Wang, Jinhui
AU  - Wang J
AD  - Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, 
      China.
AD  - Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, 
      Hangzhou, China.
FAU - Wang, Meihao
AU  - Wang M
AD  - Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, 
      Wenzhou Medical University, Wenzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20171121
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC5702526
OTO - NOTNLM
OT  - brain network
OT  - executive control
OT  - graph theory
OT  - long-range connectivity
OT  - resting-state fMRI
EDAT- 2017/12/07 06:00
MHDA- 2017/12/07 06:01
PMCR- 2017/11/21
CRDT- 2017/12/07 06:00
PHST- 2016/08/05 00:00 [received]
PHST- 2017/11/06 00:00 [accepted]
PHST- 2017/12/07 06:00 [entrez]
PHST- 2017/12/07 06:00 [pubmed]
PHST- 2017/12/07 06:01 [medline]
PHST- 2017/11/21 00:00 [pmc-release]
AID - 10.3389/fpsyt.2017.00246 [doi]
PST - epublish
SO  - Front Psychiatry. 2017 Nov 21;8:246. doi: 10.3389/fpsyt.2017.00246. eCollection 
      2017.