PMID- 29210121
OWN - NLM
STAT- MEDLINE
DCOM- 20180502
LR  - 20180502
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 32
IP  - 2
DP  - 2018 Feb
TI  - Proanthocyanidin-rich Pinus radiata bark extract inhibits mast cell-mediated 
      anaphylaxis-like reactions.
PG  - 290-297
LID - 10.1002/ptr.5973 [doi]
AB  - Mast cells play a critical role in the effector phase of immediate 
      hypersensitivity and allergic reactions. Pinus radiata bark extract exerts 
      multiple biological effects and exhibits immunomodulatory and antioxidant 
      properties. However, its role in mast cell-mediated anaphylactic reactions has 
      not been thoroughly investigated. In this study, we examined the effects of 
      proanthocyanidin-rich water extract (PAWE) isolated from P. radiata bark on 
      compound 48/80-induced or antidinitrophenyl (DNP) immunoglobulin E (IgE)-mediated 
      anaphylaxis-like reactions in vivo. In addition, we evaluated the mechanism 
      underlying the inhibitory effect of PAWE on mast cell activation, with a specific 
      focus on histamine release, using rat peritoneal mast cells. PAWE attenuated 
      compound 48/80-induced or anti-DNP IgE-mediated passive cutaneous 
      anaphylaxis-like reactions in mice, and it inhibited histamine release triggered 
      by compound 48/80, ionophore A23187, or anti-DNP IgE in rat peritoneal mast cells 
      in vitro. Moreover, PAWE suppressed compound 48/80-elicited calcium uptake in a 
      concentration-dependent manner and promoted a transient increase in intracellular 
      cyclic adenosine-3',5'-monophosphate levels. Together, these results suggest that 
      proanthocyanidin-rich P. radiata bark extract effectively inhibits 
      anaphylaxis-like reactions.
CI  - Copyright (c) 2017 John Wiley & Sons, Ltd.
FAU - Choi, Yun Ho
AU  - Choi YH
AUID- ORCID: 0000-0002-5908-9957
AD  - Department of Anatomy, Medical School, Institute for Medical Sciences, Chonbuk 
      National University, Jeonju, Jeonbuk, 561-180, Republic of Korea.
FAU - Song, Chang Ho
AU  - Song CH
AD  - Department of Anatomy, Medical School, Institute for Medical Sciences, Chonbuk 
      National University, Jeonju, Jeonbuk, 561-180, Republic of Korea.
FAU - Mun, Sung Phil
AU  - Mun SP
AD  - Department of Wood Science and Technology, College of Agriculture and Life 
      Sciences, Chonbuk National University, Jeonju, Jeonbuk, 54896, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20171206
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Plant Extracts)
RN  - 0 (Proanthocyanidins)
RN  - 18206-61-6 (proanthocyanidin)
SB  - IM
MH  - Anaphylaxis/*etiology
MH  - Animals
MH  - Hypersensitivity, Immediate
MH  - Male
MH  - Mast Cells/*drug effects
MH  - Mice
MH  - Pinus/*chemistry
MH  - Plant Extracts/*pharmacology
MH  - Proanthocyanidins/*chemistry
MH  - Rats
OTO - NOTNLM
OT  - Pinus radiata bark
OT  - anaphylactic reactions
OT  - histamine
OT  - mast cells
OT  - proanthocyanidin (PA)
EDAT- 2017/12/07 06:00
MHDA- 2018/05/03 06:00
CRDT- 2017/12/07 06:00
PHST- 2017/02/15 00:00 [received]
PHST- 2017/07/31 00:00 [revised]
PHST- 2017/10/11 00:00 [accepted]
PHST- 2017/12/07 06:00 [pubmed]
PHST- 2018/05/03 06:00 [medline]
PHST- 2017/12/07 06:00 [entrez]
AID - 10.1002/ptr.5973 [doi]
PST - ppublish
SO  - Phytother Res. 2018 Feb;32(2):290-297. doi: 10.1002/ptr.5973. Epub 2017 Dec 6.