PMID- 29212520 OWN - NLM STAT- MEDLINE DCOM- 20180717 LR - 20181113 IS - 1743-422X (Electronic) IS - 1743-422X (Linking) VI - 14 IP - 1 DP - 2017 Dec 6 TI - The relationship between human leukocyte antigen-DP/DQ gene polymorphisms and the outcomes of HCV infection in a Chinese population. PG - 235 LID - 10.1186/s12985-017-0901-7 [doi] LID - 235 AB - BACKGROUND: Recently, human leukocyte antigen (HLA) class-II gene polymorphisms have been reported to be related to Hepatitis C virus (HCV) infection and chronicity. The objective of this study was to explore the relationship of HLA-DP rs9277535 and HLA-DQ rs7453920 with the outcomes of HCV infection. METHODS: The rs9277535 and rs7453920 were genotyped in 370 subjects with chronic HCV infection, 194 subjects with spontaneous HCV clearance, and 973 subjects with non-HCV infection from the Chinese population using the ABI TaqMan allelic discrimination assay. RESULTS: Logistic regression analyses showed that the minor allele A of rs7453920 significantly increased the susceptibility of HCV infection in dominant model (adjusted OR = 1.33, 95% CI: 1.04-1.71, P = 0.026) and additive models (adjusted OR = 1.30, 95% CI: 1.06-1.60, P = 0.012). Rs9277535 A allele significantly increased the risk of chronic HCV infection in dominant model (adjusted OR = 1.52, 95% CI: 1.01-2.28, P = 0.046). Haplotype AA showed a higher risk of HCV infection than the most frequent haplotype GG (adjusted OR = 1.37, 95% CI: 1.05-1.78, P = 0.018). CONCLUSION: The HLA-DQ rs7453920 and -DP rs9277535 mutations were significantly associated with HCV infection susceptibility and chronicity, respectively. FAU - Huang, Peng AU - Huang P AD - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. AD - Institute of Epidemiology and Microbiology, Huadong Research Institute for Medicine and Biotechnics, Nanjing, China. FAU - Fan, Haozhi AU - Fan H AD - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. FAU - Tian, Ting AU - Tian T AD - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. FAU - Liao, Peiwen AU - Liao P AD - Pubilc Health Sciences Department, Karolinska Institute, Solna, Sweden. FAU - Li, Jun AU - Li J AD - Department of Infectious Diseases, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. FAU - Yu, Rongbin AU - Yu R AD - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. FAU - Xia, Xueshan AU - Xia X AD - Faculty of Life Science and Technology, Kunming University of Science and Technology, Yunnan, 650500, China. FAU - Feng, Yue AU - Feng Y AD - Faculty of Life Science and Technology, Kunming University of Science and Technology, Yunnan, 650500, China. FAU - Wang, Jie AU - Wang J AD - Department of Basic and Community Nursing, School of Nursing, Nanjing Medical University, Nanjing, 211166, China. FAU - Liu, Yuan AU - Liu Y AD - Department of Infectious Diseases, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. FAU - Zhang, Yun AU - Zhang Y AD - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. AD - Institute of Epidemiology and Microbiology, Huadong Research Institute for Medicine and Biotechnics, Nanjing, China. FAU - Yue, Ming AU - Yue M AUID- ORCID: 0000-0003-0489-4331 AD - Department of Infectious Diseases, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. njym08@163.com. LA - eng GR - 81502853/National Natural Science Foundation of China/International GR - 81473028/National Natural Science Foundation of China/International GR - 81473029/National Natural Science Foundation of China/International GR - 81703273/National Natural Science Foundation of China/International GR - 81773499/National Natural Science Foundation of China/International GR - BK20151026/Natural Science Foundation of Jiangsu Province/International GR - BK20171054/Natural Science Foundation of Jiangsu Province/International GR - QNRC2016616/Jiangsu Province Medical Young Talent/International GR - 2016NJMUZD012/the Science and Technology Development Fund Key Project of Nanjing Medical University/International PT - Journal Article DEP - 20171206 PL - England TA - Virol J JT - Virology journal JID - 101231645 RN - 0 (HLA-DP Antigens) RN - 0 (HLA-DQ Antigens) SB - IM MH - Adult MH - Case-Control Studies MH - China MH - Female MH - *Genetic Predisposition to Disease MH - Genotype MH - Genotyping Techniques MH - HLA-DP Antigens/*genetics MH - HLA-DQ Antigens/*genetics MH - Haplotypes MH - Hepatitis C/blood/*genetics/pathology MH - Humans MH - Male MH - Middle Aged MH - *Polymorphism, Single Nucleotide PMC - PMC5719872 OTO - NOTNLM OT - Drug use OT - Gene polymorphism OT - HLA OT - Hemodialysis OT - Hepatitis C virus OT - Paid blood donors COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Each participates was recruited prior informed consent, agreed to participate in this study and sample collection. The study followed the Helsinki Declaration and was approved by the Institutional Review Board of Nanjing Medical University (Nanjing, China). CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2017/12/08 06:00 MHDA- 2018/07/18 06:00 PMCR- 2017/12/06 CRDT- 2017/12/08 06:00 PHST- 2017/07/10 00:00 [received] PHST- 2017/11/20 00:00 [accepted] PHST- 2017/12/08 06:00 [entrez] PHST- 2017/12/08 06:00 [pubmed] PHST- 2018/07/18 06:00 [medline] PHST- 2017/12/06 00:00 [pmc-release] AID - 10.1186/s12985-017-0901-7 [pii] AID - 901 [pii] AID - 10.1186/s12985-017-0901-7 [doi] PST - epublish SO - Virol J. 2017 Dec 6;14(1):235. doi: 10.1186/s12985-017-0901-7.