PMID- 29213676
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 1980-5764 (Print)
IS  - 1980-5764 (Linking)
VI  - 4
IP  - 2
DP  - 2010 Apr-Jun
TI  - Parkinson's disease: Impact of clinical and cognitive aspects on quality of life.
PG  - 131-137
LID - 10.1590/S1980-57642010DN40200010 [doi]
AB  - Parkinson's disease (PD) is a chronic disease manifested principally by motor 
      signs and symptoms, but with frequent neuropsychological alterations. OBJECTIVES: 
      To study the relationship between clinical and cognitive aspects and the 
      perception of quality of life (QOL) in PD patients. METHODS: Twenty consecutive 
      patients (13 men) with idiopathic PD (mean age: 64.5y), mean disease time of 7.8 
      years and at stages 1-3 according to the modified Hoehn and Yahr staging scale 
      (HYS), all outpatients from the Neurology Department of the Celso Pierro General 
      and Maternity Hospital (PUC-Campinas), were analyzed. The following were applied: 
      a clinical-neurological assessment, the Mini-Mental State Examination (MMSE), 
      standard neuropsychological battery of the CERAD (Consortium to Establish a 
      Registry for Alzheimer's Disease), Hamilton Depression Rating Scale (HAM-D) and a 
      QOL questionnaire (Parkinson's Disease Questionnaire - PDQ-39). Statistical 
      analysis was carried out at a significance level of p<0.05. RESULTS: On the 
      PDQ-39 under the sections total, mobility and activities of daily living, and the 
      items motor compromise (HYS) and language of the MMSE were predictors of worse 
      QOL. Verbal fluency was a factor for emotional well-being on the PDQ-39, whereas 
      higher scores for HAM-D and worse performance on the item attention and 
      calculation of the MMSE were associated with worse QOL in the social support 
      section. Total score on the MMSE and educational level were QOL factors in 
      cognition. CONCLUSIONS: The findings of the present study suggest that clinical, 
      cognitive, motor or other depression-related factors contribute differently to 
      the domains of QOL.
FAU - Tedrus, Gloria Maria Almeida Souza
AU  - Tedrus GMAS
AD  - Professor of Neurology, Pontificia Universidade Catolica de Campinas, Campinas 
      SP, Brazil (PUC-Campinas), Scholarship holders.
FAU - Fonseca, Lineu Correa
AU  - Fonseca LC
AD  - Professor of Neurology, Pontificia Universidade Catolica de Campinas, Campinas 
      SP, Brazil (PUC-Campinas), Scholarship holders.
FAU - Kange, Patricia Mencaroni
AU  - Kange PM
AD  - Student of Faculty of Medicine with FAPIC placement scholarship - Catholic 
      University of Campinas (PUC-Campinas), Campinas SP, Brazil.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Dement Neuropsychol
JT  - Dementia & neuropsychologia
JID - 101506587
PMC - PMC5619172
OTO - NOTNLM
OT  - Parkinson's disease
OT  - cognition
OT  - depression
OT  - quality of life
COIS- Disclosure: The authors report no conflicts of interest.
EDAT- 2010/04/01 00:00
MHDA- 2010/04/01 00:01
PMCR- 2010/04/01
CRDT- 2017/12/08 06:00
PHST- 2017/12/08 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2010/04/01 00:01 [medline]
PHST- 2010/04/01 00:00 [pmc-release]
AID - 10.1590/S1980-57642010DN40200010 [doi]
PST - ppublish
SO  - Dement Neuropsychol. 2010 Apr-Jun;4(2):131-137. doi: 
      10.1590/S1980-57642010DN40200010.