PMID- 29213793
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 1980-5764 (Print)
IS  - 1980-5764 (Linking)
VI  - 6
IP  - 3
DP  - 2012 Jul-Sep
TI  - Behavioral and psychological symptoms and hippocampal atrophy in subcortical 
      ischaemic vascular disease.
PG  - 175-179
LID - 10.1590/S1980-57642012DN06030011 [doi]
AB  - BACKGROUND: Neuropsychiatric symptoms are common in patients with cognitive 
      impairments, mediated by both neurodegenerative processes and cerebrovascular 
      disease. Previous studies have reported that Behavioral and Psychological 
      Symptoms of Dementia (BPSD) might correlate with severity of cognitive decline. 
      Thus far, the impact of the association between white-matter hyperintensities 
      (WHM) and hippocampal atrophy (HA) on the incidence of these symptoms has been 
      less studied. OBJECTIVE: This cross-sectional study aimed to describe the 
      clinical profile of a sample with large extensions of WMH, examining the 
      association between different degrees of HA and cognitive, functional, and 
      behavioral status. METHODS: Fifty outpatients (mean age: 76.86+/-8.70 years; 58% 
      female; mean schooling: 7.44+/-4.69 years) with large extensions of WMH 
      (modified-Fazekas scale=3) on MRI and different degrees of hippocampal atrophy 
      (according to de Leon Score) underwent cognitive, functional, and behavioral 
      assessments. RESULTS: Patients with mild-moderate to severe HA had worse 
      performance on the Mini-Mental State Examination, Cambridge Cognitive 
      Examination, Clinical Dementia Rating and Pfeffer's Functional Activities 
      Questionnaire, compared to the group with none or questionable HA. 
      Appetite/Eating Behavior was the only cluster of neuropsychiatric symptoms 
      associated with presence of HA in Vascular Cognitive Impairment patients. 
      DISCUSSION: Although HA may exhibit distinct impact on cognitive performance and 
      functional status, it appears to have little effect on behavioral symptoms in 
      patients with high severity WMH.
FAU - Tiel, Chan
AU  - Tiel C
AD  - Instituto de Neurologia Deolindo Couto, Universidade Federal do Rio de Janeiro, 
      Rio de Janeiro RJ, Brazil.
AD  - Cognitive and Behavioral Neurology Unit, INDC-CDA/IPUB, Universidade Federal do 
      Rio de Janeiro, Rio de Janeiro RJ, Brazil.
FAU - Sudo, Felipe Kenji
AU  - Sudo FK
AD  - Instituto de Psiquiatria, Center for Alzheimer's Disease (CDA/IPUB), Universidade 
      Federal do Rio de Janeiro, Rio de Janeiro RJ, Brazil.
FAU - Alves, Carlos Eduardo Oliveira
AU  - Alves CEO
AD  - Instituto de Psiquiatria, Center for Alzheimer's Disease (CDA/IPUB), Universidade 
      Federal do Rio de Janeiro, Rio de Janeiro RJ, Brazil.
FAU - Alves, Gilberto Sousa
AU  - Alves GS
AD  - Instituto de Psiquiatria, Center for Alzheimer's Disease (CDA/IPUB), Universidade 
      Federal do Rio de Janeiro, Rio de Janeiro RJ, Brazil.
FAU - Ericeira-Valente, Letice
AU  - Ericeira-Valente L
AD  - Instituto de Psiquiatria, Center for Alzheimer's Disease (CDA/IPUB), Universidade 
      Federal do Rio de Janeiro, Rio de Janeiro RJ, Brazil.
FAU - Moreira, Denise Madeira
AU  - Moreira DM
AD  - Instituto de Neurologia Deolindo Couto, Universidade Federal do Rio de Janeiro, 
      Rio de Janeiro RJ, Brazil.
AD  - Hospital Pro-Cardiaco, Rio de Janeiro, Rio de Janeiro RJ, Brazil.
FAU - Laks, Jerson
AU  - Laks J
AD  - Instituto de Psiquiatria, Center for Alzheimer's Disease (CDA/IPUB), Universidade 
      Federal do Rio de Janeiro, Rio de Janeiro RJ, Brazil.
AD  - Universidade do Estado Rio de Janeiro, Rio de Janeiro RJ, Brazil.
FAU - Engelhardt, Eliasz
AU  - Engelhardt E
AD  - Instituto de Neurologia Deolindo Couto, Universidade Federal do Rio de Janeiro, 
      Rio de Janeiro RJ, Brazil.
AD  - Cognitive and Behavioral Neurology Unit, INDC-CDA/IPUB, Universidade Federal do 
      Rio de Janeiro, Rio de Janeiro RJ, Brazil.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Dement Neuropsychol
JT  - Dementia & neuropsychologia
JID - 101506587
PMC - PMC5618966
OTO - NOTNLM
OT  - cerebrovascular disease
OT  - executive function
OT  - neuroimaging
OT  - neuropsychiatry
OT  - neuropsychology
OT  - vascular dementia
COIS- Disclosure: The authors report no conflicts of interest.
EDAT- 2012/07/01 00:00
MHDA- 2012/07/01 00:01
PMCR- 2012/07/01
CRDT- 2017/12/08 06:00
PHST- 2017/12/08 06:00 [entrez]
PHST- 2012/07/01 00:00 [pubmed]
PHST- 2012/07/01 00:01 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - 10.1590/S1980-57642012DN06030011 [doi]
PST - ppublish
SO  - Dement Neuropsychol. 2012 Jul-Sep;6(3):175-179. doi: 
      10.1590/S1980-57642012DN06030011.