PMID- 29214461
OWN - NLM
STAT- MEDLINE
DCOM- 20180803
LR  - 20181113
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Linking)
VI  - 118
IP  - 2
DP  - 2018 Feb
TI  - Co-ingestion of protein or a protein hydrolysate with carbohydrate enhances 
      anabolic signaling, but not glycogen resynthesis, following recovery from 
      prolonged aerobic exercise in trained cyclists.
PG  - 349-359
LID - 10.1007/s00421-017-3775-x [doi]
AB  - PURPOSE: The effect of carbohydrate (CHO), or CHO supplemented with either sodium 
      caseinate protein (CHO-C) or a sodium caseinate protein hydrolysate (CHO-H) on 
      the recovery of skeletal muscle glycogen and anabolic signaling following 
      prolonged aerobic exercise was determined in trained male cyclists [n = 11, 
      mean +/- SEM age 28.8 +/- 2.3 years; body mass (BM) 75.0 +/- 2.3 kg; VO(2peak) 
      61.3 +/- 1.6 ml kg(-1) min(-1)]. METHODS: On three separate occasions, participants 
      cycled for 2 h at ~ 70% VO(2peak) followed by a 4-h recovery period. Isoenergetic 
      drinks were consumed at + 0 and + 2 h of recovery containing either (1) CHO 
      (1.2 g kg (-1) BM), (2) CHO-C, or (3) CHO-H (1.04 and 0.16 g kg(-1) BM, 
      respectively) in a randomized, double-blind, cross-over design. Muscle biopsies 
      from the vastus lateralis were taken prior to commencement of each trial, and at 
      + 0 and + 4 h of recovery for determination of skeletal muscle glycogen, and 
      intracellular signaling associated with protein synthesis. RESULTS: Despite an 
      augmented insulin response following CHO-H ingestion, there was no significant 
      difference in skeletal muscle glycogen resynthesis following recovery between 
      trials. CHO-C and CHO-H co-ingestion significantly increased phospho-mTOR 
      Ser(2448) and 4EBP1 Thr(37/46) versus CHO, with CHO-H displaying the greatest 
      change in phospho-4EBP1 Thr(37/46). Protein co-ingestion, compared to CHO alone, 
      during recovery did not augment glycogen resynthesis. CONCLUSION: Supplementing 
      CHO with intact sodium caseinate or an insulinotropic hydrolysate derivative 
      augmented intracellular signaling associated with skeletal muscle protein 
      synthesis following prolonged aerobic exercise.
FAU - Cogan, Karl E
AU  - Cogan KE
AD  - Institute for Sport and Health, University College Dublin, Dublin, Ireland.
AD  - Food for Health Ireland, University College Dublin, Dublin, Ireland.
FAU - Evans, Mark
AU  - Evans M
AD  - School of Health and Human Performance, Dublin City University, Glasnevin, Dublin 
      9, Ireland.
FAU - Iuliano, Enzo
AU  - Iuliano E
AD  - Institute for Sport and Health, University College Dublin, Dublin, Ireland.
AD  - Department of Medicine and Health Sciences, University of Molise, Campobasso, 
      Italy.
FAU - Melvin, Audrey
AU  - Melvin A
AD  - Diabetes Complications Research Centre, Conway Institute of Biomolecular and 
      Biomedical Science, University College Dublin, Dublin, Ireland.
FAU - Susta, Davide
AU  - Susta D
AD  - School of Health and Human Performance, Dublin City University, Glasnevin, Dublin 
      9, Ireland.
FAU - Neff, Karl
AU  - Neff K
AD  - Diabetes Complications Research Centre, Conway Institute of Biomolecular and 
      Biomedical Science, University College Dublin, Dublin, Ireland.
FAU - De Vito, Giuseppe
AU  - De Vito G
AD  - Institute for Sport and Health, University College Dublin, Dublin, Ireland.
FAU - Egan, Brendan
AU  - Egan B
AUID- ORCID: 0000-0001-8327-9016
AD  - Institute for Sport and Health, University College Dublin, Dublin, Ireland. 
      brendan.egan@dcu.ie.
AD  - Food for Health Ireland, University College Dublin, Dublin, Ireland. 
      brendan.egan@dcu.ie.
AD  - School of Health and Human Performance, Dublin City University, Glasnevin, Dublin 
      9, Ireland. brendan.egan@dcu.ie.
LA  - eng
GR  - TC2013001/Enterprise Ireland/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20171206
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - 0 (Caseins)
RN  - 0 (Dietary Carbohydrates)
RN  - 9005-79-2 (Glycogen)
SB  - IM
MH  - Adult
MH  - Caseins/administration & dosage/*metabolism/pharmacology
MH  - Dietary Carbohydrates/administration & dosage/*metabolism/pharmacology
MH  - *Exercise
MH  - Glycogen/*biosynthesis
MH  - Humans
MH  - Male
MH  - Muscle Fatigue
MH  - Muscle, Skeletal/*drug effects/metabolism/physiology
MH  - *Recovery of Function
MH  - Signal Transduction
OTO - NOTNLM
OT  - Cycling
OT  - Nutrition
OT  - Protein synthesis
OT  - Sodium caseinate
OT  - Supplementation
EDAT- 2017/12/08 06:00
MHDA- 2018/08/04 06:00
CRDT- 2017/12/08 06:00
PHST- 2017/06/17 00:00 [received]
PHST- 2017/11/29 00:00 [accepted]
PHST- 2017/12/08 06:00 [pubmed]
PHST- 2018/08/04 06:00 [medline]
PHST- 2017/12/08 06:00 [entrez]
AID - 10.1007/s00421-017-3775-x [pii]
AID - 10.1007/s00421-017-3775-x [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2018 Feb;118(2):349-359. doi: 10.1007/s00421-017-3775-x. Epub 
      2017 Dec 6.