PMID- 29214532
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20221207
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 410
IP  - 2
DP  - 2018 Jan
TI  - Qualitative and quantitative temporal analysis of licit and illicit drugs in 
      wastewater in Australia using liquid chromatography coupled to mass spectrometry.
PG  - 529-542
LID - 10.1007/s00216-017-0747-2 [doi]
AB  - The combination of qualitative and quantitative bimonthly analysis of 
      pharmaceuticals and illicit drugs using liquid chromatography coupled to mass 
      spectrometry is presented. A liquid chromatography-quadrupole time of flight 
      instrument equipped with Sequential Window Acquisition of all THeoretical 
      fragment-ion spectra (SWATH) was used to qualitatively screen 346 compounds in 
      influent wastewater from two wastewater treatment plants in South Australia over 
      a 14-month period. A total of 100 compounds were confirmed and/or detected using 
      this strategy, with 61 confirmed in all samples including antidepressants 
      (amitriptyline, dothiepin, doxepin), antipsychotics (amisulpride, clozapine), 
      illicit drugs (cocaine, methamphetamine, amphetamine, 
      3,4-methylenedioxymethamphetamine (MDMA)), and known drug adulterants (lidocaine 
      and tetramisole). A subset of these compounds was also included in a quantitative 
      method, analyzed on a liquid chromatography-triple quadrupole mass spectrometer. 
      The use of illicit stimulants (methamphetamine) showed a clear decrease, levels 
      of opioid analgesics (morphine and methadone) remained relatively stable, while 
      the use of new psychoactive substances (methylenedioxypyrovalerone (MDPV) and 
      Alpha PVP) varied with no visible trend. This work demonstrates the value that 
      high-frequency sampling combined with quantitative and qualitative analysis can 
      deliver. Graphical abstract Temporal analysis of licit and illicit drugs in South 
      Australia.
FAU - Bade, Richard
AU  - Bade R
AD  - School of Pharmacy and Medical Sciences, University of South Australia, GPO Box 
      2471, Adelaide, South Australia, 5001, Australia.
FAU - White, Jason M
AU  - White JM
AD  - School of Pharmacy and Medical Sciences, University of South Australia, GPO Box 
      2471, Adelaide, South Australia, 5001, Australia.
FAU - Gerber, Cobus
AU  - Gerber C
AD  - School of Pharmacy and Medical Sciences, University of South Australia, GPO Box 
      2471, Adelaide, South Australia, 5001, Australia. Cobus.Gerber@unisa.edu.au.
LA  - eng
PT  - Journal Article
DEP - 20171206
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Illicit Drugs)
RN  - 0 (Waste Water)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Australia
MH  - Chromatography, Liquid/methods
MH  - Illicit Drugs/*analysis
MH  - Solid Phase Extraction/methods
MH  - Tandem Mass Spectrometry/*methods
MH  - Wastewater/*analysis
MH  - Water Pollutants, Chemical/*analysis
OTO - NOTNLM
OT  - High resolution mass spectrometry
OT  - Illicit drugs
OT  - New psychoactive substances
OT  - Pharmaceuticals
OT  - Triple quadrupole
OT  - Wastewater
EDAT- 2017/12/08 06:00
MHDA- 2018/03/10 06:00
CRDT- 2017/12/08 06:00
PHST- 2017/09/05 00:00 [received]
PHST- 2017/11/05 00:00 [accepted]
PHST- 2017/11/02 00:00 [revised]
PHST- 2017/12/08 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
PHST- 2017/12/08 06:00 [entrez]
AID - 10.1007/s00216-017-0747-2 [pii]
AID - 10.1007/s00216-017-0747-2 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2018 Jan;410(2):529-542. doi: 10.1007/s00216-017-0747-2. Epub 
      2017 Dec 6.