PMID- 29215761
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20190520
IS  - 1600-0625 (Electronic)
IS  - 0906-6705 (Linking)
VI  - 27
IP  - 2
DP  - 2018 Feb
TI  - In vivo differentiation of common basal cell carcinoma subtypes by microvascular 
      and structural imaging using dynamic optical coherence tomography.
PG  - 156-165
LID - 10.1111/exd.13479 [doi]
AB  - The subtype of basal cell carcinoma (BCC) influences the choice of treatment. 
      Optical coherence tomography (OCT) is a non-invasive imaging tool, and a recent 
      development of an angiographic version of OCT has extended the application of OCT 
      to image the cutaneous microvasculature (so-called dynamic OCT, D-OCT). This 
      study explores D-OCT's ability to differentiate the common BCC subtypes by 
      microvascular and structural imaging. Eighty-one patients with 98 BCC lesions, 
      consisting of three subtypes: 27 superficial BCC (sBCC), 55 nodular BCC (nBCC) 
      and 16 infiltrative BCC (iBCC) were D-OCT scanned at three European dermatology 
      centres. Blinded evaluations of microvascular and structural features were 
      performed, followed by extensive statistical analysis of risk ratio (RR) and 
      multiple correspondence analysis. nBCC lesions displayed most characteristic 
      structural and vascular features. Serpiginous vessels, branching vessels, vessels 
      creating a circumscribed figure and sharply demarcated hyporeflective ovoid 
      structures in the dermis were all associated with a higher risk of the subtype 
      being nBCC. The presence of highly present lines and dark peripheral borders at 
      the margin of ovoid structures was negatively associated with iBCC. Lastly, the 
      finding of hyporeflective ovoid structures protruding from epidermis correlated 
      with sBCC. We identified various microvascular and structural D-OCT features that 
      may aid non-invasive identification of BCC subtypes. This would allow clinicians 
      to individualize and optimize BCC treatment as well as aid follow-up of 
      non-surgical treatment.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Themstrup, Lotte
AU  - Themstrup L
AUID- ORCID: 0000-0003-1368-1522
AD  - Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.
AD  - Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - De Carvalho, Nathalie
AU  - De Carvalho N
AUID- ORCID: 0000-0002-0823-5731
AD  - Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
FAU - Nielsen, Sabrina M
AU  - Nielsen SM
AD  - Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and 
      Frederiksberg Hospital, Frederiksberg, Copenhagen, Denmark.
FAU - Olsen, Jonas
AU  - Olsen J
AD  - Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.
AD  - Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Ciardo, Silvana
AU  - Ciardo S
AD  - Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
FAU - Schuh, Sandra
AU  - Schuh S
AD  - Department of Dermatology and Allergology, General Hospital Augsburg, Augsburg, 
      Germany.
FAU - Nornberg, Birgit M-H
AU  - Nornberg BM
AD  - Department of Pathology, Zealand University Hospital, Roskilde, Denmark.
FAU - Welzel, Julia
AU  - Welzel J
AD  - Department of Dermatology and Allergology, General Hospital Augsburg, Augsburg, 
      Germany.
FAU - Ulrich, Martina
AU  - Ulrich M
AD  - CMB/Collegium Medicum Berlin, Berlin, Germany.
FAU - Pellacani, Giovanni
AU  - Pellacani G
AD  - Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
FAU - Jemec, Gregor B E
AU  - Jemec GBE
AD  - Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.
AD  - Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 
      Denmark.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180110
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
SB  - IM
MH  - Aged
MH  - Biopsy
MH  - Carcinoma, Basal Cell/*diagnostic imaging/*pathology
MH  - Cell Differentiation
MH  - Europe
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Male
MH  - *Microcirculation
MH  - Middle Aged
MH  - Neovascularization, Pathologic
MH  - Observer Variation
MH  - Random Allocation
MH  - Risk
MH  - Skin Neoplasms/*diagnostic imaging/*pathology
MH  - *Tomography, Optical Coherence
OTO - NOTNLM
OT  - OCT angiography
OT  - biophotonics
OT  - keratinocyte carcinoma
OT  - non-invasive imaging
OT  - non-melanoma skin cancer
EDAT- 2017/12/08 06:00
MHDA- 2019/05/21 06:00
CRDT- 2017/12/08 06:00
PHST- 2017/11/30 00:00 [accepted]
PHST- 2017/12/08 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
PHST- 2017/12/08 06:00 [entrez]
AID - 10.1111/exd.13479 [doi]
PST - ppublish
SO  - Exp Dermatol. 2018 Feb;27(2):156-165. doi: 10.1111/exd.13479. Epub 2018 Jan 10.