PMID- 29216509
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20180827
IS  - 1872-7077 (Electronic)
IS  - 1382-6689 (Linking)
VI  - 57
DP  - 2018 Jan
TI  - In vitro study on the joint hepatoxicity upon combined exposure of cadmium and 
      BDE-209.
PG  - 62-69
LID - S1382-6689(17)30321-6 [pii]
LID - 10.1016/j.etap.2017.11.015 [doi]
AB  - Joint toxicity is an important issue during the risk assessment of environmental 
      pollutants. Contamination of heavy metals and persistent organic pollutants 
      (POPs) under the environmental and biological settings poses substantial health 
      risk to humans. Although previous studies demonstrated the co-occurrence of 
      cadmium and decabrominated diphenyl ether (BDE-209) in environmental mediums, 
      food chains and even human body, their potentially joint toxicities remain 
      elusive thus far. Our investigation here with respect to the hepatotoxicity in 
      vitro clearly demonstrated that combined exposure of cadmium and BDE-209 
      aggravated the injuries in hepatocytes, which was evidenced by the additive 
      effects on the induction of remarkable morphological alternations, LDH release, 
      cell apoptosis and necrosis, impairment of mitochondrial activity and 
      transmembrane potential. Enhanced ROS production was one of the mechanisms for 
      cell apoptosis and death upon joint treatment. Additionally, more cadmium-treated 
      cells underwent apoptosis than BDE-209-treated cells while more ROS was generated 
      with BDE-209 treatment, indicating that other mechanisms might be involved in 
      cadmium-induced apoptosis. Our results would be helpful for evaluating the 
      joint-hepatotoxicity upon combined exposure of cadmium and BDE-209 as well as 
      investigating the underlying mechanisms.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Wang, Lixin
AU  - Wang L
AD  - College of Environmental Science and Engineering, Hebei University of Science and 
      Technology, Shijiazhuang 050018, China. Electronic address: 
      lixinwang2017@hebust.edu.cn.
FAU - Zheng, Miaomiao
AU  - Zheng M
AD  - College of Environmental Science and Engineering, Hebei University of Science and 
      Technology, Shijiazhuang 050018, China.
FAU - Gao, Yu
AU  - Gao Y
AD  - College of Environmental Science and Engineering, Hebei University of Science and 
      Technology, Shijiazhuang 050018, China; Xiqing District Environmental Protection 
      Monitoring Station, Tianjin 300380, China.
FAU - Cui, Jiansheng
AU  - Cui J
AD  - College of Environmental Science and Engineering, Hebei University of Science and 
      Technology, Shijiazhuang 050018, China. Electronic address: 
      cuijiansheng@hebust.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20171129
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Reactive Oxygen Species)
RN  - 00BH33GNGH (Cadmium)
RN  - N80BQ29A0H (decabromobiphenyl ether)
SB  - IM
MH  - Apoptosis/drug effects
MH  - Cadmium/*toxicity
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - Drug Synergism
MH  - Environmental Pollutants/toxicity
MH  - Halogenated Diphenyl Ethers/*toxicity
MH  - Hepatocytes/*drug effects/metabolism
MH  - Humans
MH  - Reactive Oxygen Species/metabolism
OTO - NOTNLM
OT  - BDE-209
OT  - Cadmium
OT  - Combined exposure
OT  - In vitro
OT  - Joint hepatoxicity
OT  - ROS
EDAT- 2017/12/08 06:00
MHDA- 2018/08/28 06:00
CRDT- 2017/12/08 06:00
PHST- 2017/10/20 00:00 [received]
PHST- 2017/11/27 00:00 [revised]
PHST- 2017/11/28 00:00 [accepted]
PHST- 2017/12/08 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
PHST- 2017/12/08 06:00 [entrez]
AID - S1382-6689(17)30321-6 [pii]
AID - 10.1016/j.etap.2017.11.015 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2018 Jan;57:62-69. doi: 10.1016/j.etap.2017.11.015. 
      Epub 2017 Nov 29.