PMID- 29217283
OWN - NLM
STAT- MEDLINE
DCOM- 20190117
LR  - 20210109
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 136
IP  - Pt B
DP  - 2018 Jul 1
TI  - Insulin-mediated synaptic plasticity in the CNS: Anatomical, functional and 
      temporal contexts.
PG  - 182-191
LID - S0028-3908(17)30590-7 [pii]
LID - 10.1016/j.neuropharm.2017.12.001 [doi]
AB  - For decades the brain was erroneously considered an insulin insensitive organ. 
      Although gaps in our knowledge base remain, conceptual frameworks are starting to 
      emerge to provide insight into the mechanisms through which insulin facilitates 
      critical brain functions like metabolism, cognition, and motivated behaviors. 
      These diverse physiological and behavioral activities highlight the 
      region-specific activities of insulin in the CNS; that is, there is an anatomical 
      context to the activities of insulin in the CNS. Similarly, there is also a 
      temporal context to the activities of insulin in the CNS. Indeed, brain insulin 
      receptor activity can be conceptualized as a continuum in which insulin promotes 
      neuroplasticity from development into adulthood where it is an integral part of 
      healthy brain function. Unfortunately, brain insulin resistance likely 
      contributes to neuroplasticity deficits in obesity and type 2 diabetes mellitus 
      (T2DM). This neuroplasticity continuum can be conceptualized by the mechanisms 
      through which insulin promotes cognitive function through its actions in brain 
      regions like the hippocampus, as well as the ability of insulin to modulate 
      motivated behaviors through actions in brain regions like the nucleus accumbens 
      and the ventral tegmental area. Thus, the goals of this review are to highlight 
      these anatomical, temporal, and functional contexts of insulin activity in these 
      brain regions, and to identify potentially critical time points along this 
      continuum where the transition from enhancement of neuroplasticity to impairment 
      may take place. This article is part of the Special Issue entitled 'Metabolic 
      Impairment as Risk Factors for Neurodegenerative Disorders.'
CI  - Copyright (c) 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Ferrario, Carrie R
AU  - Ferrario CR
AD  - Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 
      48109, USA. Electronic address: Ferrario@umich.edu.
FAU - Reagan, Lawrence P
AU  - Reagan LP
AD  - Department of Pharmacology, Physiology and Neuroscience, University of South 
      Carolina School of Medicine, Columbia, SC 29208, USA; W.J.B. Dorn VA Medical 
      Center, Columbia, SC 29208, USA.
LA  - eng
GR  - I01 BX001804/BX/BLRD VA/United States
GR  - I01 BX002664/BX/BLRD VA/United States
GR  - R01 DK106188/DK/NIDDK NIH HHS/United States
GR  - R01 DK115526/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20171205
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Insulin)
SB  - IM
MH  - Animals
MH  - Central Nervous System/anatomy & histology/*metabolism
MH  - Humans
MH  - Insulin/*metabolism
MH  - Neuronal Plasticity/*physiology
PMC - PMC5988909
MID - NIHMS927597
OTO - NOTNLM
OT  - Cognition
OT  - Glutamate
OT  - Hippocampus
OT  - Motivation
OT  - Nucleus accumbens
OT  - Ventral tegmental area
COIS- The authors have no conflicts of interest to declare.
EDAT- 2017/12/09 06:00
MHDA- 2019/01/18 06:00
PMCR- 2019/07/01
CRDT- 2017/12/09 06:00
PHST- 2017/10/16 00:00 [received]
PHST- 2017/12/01 00:00 [revised]
PHST- 2017/12/03 00:00 [accepted]
PHST- 2017/12/09 06:00 [pubmed]
PHST- 2019/01/18 06:00 [medline]
PHST- 2017/12/09 06:00 [entrez]
PHST- 2019/07/01 00:00 [pmc-release]
AID - S0028-3908(17)30590-7 [pii]
AID - 10.1016/j.neuropharm.2017.12.001 [doi]
PST - ppublish
SO  - Neuropharmacology. 2018 Jul 1;136(Pt B):182-191. doi: 
      10.1016/j.neuropharm.2017.12.001. Epub 2017 Dec 5.