PMID- 29217485
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20181126
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 81
DP  - 2018 Apr
TI  - Developmental origins of adult health and disease: The metabolic role of BDNF 
      from early life to adulthood.
PG  - 45-51
LID - S0026-0495(17)30331-1 [pii]
LID - 10.1016/j.metabol.2017.11.019 [doi]
AB  - Accumulating evidence suggests that the origins of adult disease may occur during 
      fetal life. Thus, the concept of "developmental programming" has been introduced 
      and supported by epidemiological and experimental data. This concept supports the 
      idea that the nutritional and hormonal status during pregnancy could interfere in 
      metabolism control. The mechanisms responsible for this "developmental 
      programming" remain poorly documented. Current research indicates that 
      neurotrophins and particularly brain-derived neurotrophic factor (BDNF) may play 
      a crucial role in this process. Although mainly expressed in the nervous system, 
      BDNF and its receptor, tropomyosin-related kinase B (TrkB), are immunolocalized 
      in several regions of the human placenta and have important functions during 
      pregnancy. BDNF serves widespread roles in regulating energy homeostasis in both 
      fetuses and adults, by controlling patterns of fetal growth, adult feeding and 
      physical activity, and by regulating glucose metabolism in peripheral tissues. 
      Impaired BDNF signaling may be implicated in the etiopathogenesis of the 
      metabolic syndrome. Novel BDNF-focused interventions are being developed for 
      obesity, diabetes and neurological disorders. The aim of this article is to 
      provide a brief comprehensive literary review regarding the potential 
      implications of BDNF in "developmental programming", through regulation of 
      metabolism and energy balance from early life to adulthood.
CI  - Copyright (c) 2017. Published by Elsevier Inc.
FAU - Briana, Despina D
AU  - Briana DD
AD  - Department of Neonatology, National and Kapodistrian University of Athens, 
      Athens, Greece.
FAU - Malamitsi-Puchner, Ariadne
AU  - Malamitsi-Puchner A
AD  - Department of Neonatology, National and Kapodistrian University of Athens, 
      Athens, Greece. Electronic address: amalpu@med.uoa.gr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171205
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - *Fetal Development
MH  - Fetal Growth Retardation/etiology
MH  - Homeostasis
MH  - Humans
MH  - Metabolic Diseases/metabolism
MH  - Obesity/metabolism
OTO - NOTNLM
OT  - Adult
OT  - BDNF
OT  - Fetus
OT  - Metabolism
OT  - Placenta
EDAT- 2017/12/09 06:00
MHDA- 2018/11/27 06:00
CRDT- 2017/12/09 06:00
PHST- 2017/07/08 00:00 [received]
PHST- 2017/11/22 00:00 [revised]
PHST- 2017/11/29 00:00 [accepted]
PHST- 2017/12/09 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2017/12/09 06:00 [entrez]
AID - S0026-0495(17)30331-1 [pii]
AID - 10.1016/j.metabol.2017.11.019 [doi]
PST - ppublish
SO  - Metabolism. 2018 Apr;81:45-51. doi: 10.1016/j.metabol.2017.11.019. Epub 2017 Dec 
      5.