PMID- 29217651
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2049-3614 (Print)
IS  - 2049-3614 (Electronic)
IS  - 2049-3614 (Linking)
VI  - 7
IP  - 1
DP  - 2018 Jan
TI  - Interleukin-18 serum level is elevated in type 2 diabetes and latent autoimmune 
      diabetes.
PG  - 179-185
LID - 10.1530/EC-17-0273 [doi]
AB  - BACKGROUND: Interleukin-18 (IL-18) is an inflammatory cytokine found to be 
      elevated in obesity, metabolic syndrome and type 2 diabetes (T2D) as a part of 
      the chronic low-grade inflammatory process in these states. The aim of the study 
      was to evaluate the interleukin level in patients with latent autoimmune diabetes 
      of the adults (LADA) in comparison to that in T2D subjects. MATERIALS AND 
      METHODS: IL-18 was analyzed through enzyme-linked immunosorbent assay in 76 
      participants with T2D and 24 with LADA and 14 control subjects. Evaluation was 
      also carried out in body mass index (BMI)- and glycemic control-matched diabetic 
      patients. RESULTS: The serum concentration of IL-18 was higher in patients with 
      T2D (389.04 +/- 203.44 pg/mL) and LADA (327.04 +/- 144.48 pg/mL) than that in control 
      subjects (219.88 +/- 91.03 pg/mL), P < 0.05. However, it was not significantly 
      different between both diabetic groups (P = 0.255) despite higher IL-6 
      (4.78 +/- 5.84 vs 1.79 +/- 0.96 pg/mL, P < 0.001) and hs-CRP (2.60 +/- 1.70 vs 
      1.29 +/- 1.20 mg/L, P = 0.002) level in T2D patients. The results were persistent 
      in BMI-matched subjects with diabetes (IL-18 = 403.48 +/- 226.32 vs 
      329.30 +/- 146.30 pg/mL, respectively for T2D and LADA, P = 0.391). The 
      correlations in T2D group concerning HDL cholesterol (r = -0.377, P = 0.001), 
      postprandial glucose (r = 0.244, P = 0.043), IL-6 (r = 0.398, P < 0.001) and 
      hs-CRP (r = 0.427, P = 0.001) were not confirmed in LADA and control subjects. 
      CONCLUSION: The IL-18 serum level was higher in T2D and LADA than that in control 
      subjects, but did not differ between both diabetic groups, even when they were 
      BMI matched. Correlations with lipid, glycemic and inflammatory parameters were 
      present in T2D only.
CI  - (c) 2018 The authors.
FAU - Zaharieva, Emanuela
AU  - Zaharieva E
AD  - Department of Internal MedicineUniversity Hospital Alexandrovska, Clinic of 
      Endocrinology, Faculty of Medicine, Medical University-Sofia, Sofia, Bulgaria.
FAU - Kamenov, Zdravko
AU  - Kamenov Z
AD  - Department of Internal MedicineUniversity Hospital Alexandrovska, Clinic of 
      Endocrinology, Faculty of Medicine, Medical University-Sofia, Sofia, Bulgaria 
      zkamenov@hotmail.com.
FAU - Velikova, Tsvetelina
AU  - Velikova T
AD  - Department of Clinical ImmunologyUniversity Hospital St. Ivan Rilski, Laboratory 
      of Clinical Immunology, Faculty of Medicine, Medical University-Sofia, Sofia, 
      Bulgaria.
FAU - Tsakova, Adelina
AU  - Tsakova A
AD  - Department of Clinical LaboratoryUniversity Hospital Alexandrovska, Central 
      Clinical Laboratory, Faculty of Medicine, Medical University-Sofia, Sofia, 
      Bulgaria.
FAU - El-Darawish, Yosif
AU  - El-Darawish Y
AD  - Laboratory of Tumor Immunology and Cell TherapyHyogo College of Medicine, Hyogo, 
      Japan.
FAU - Okamura, Haruki
AU  - Okamura H
AD  - Laboratory of Tumor Immunology and Cell TherapyHyogo College of Medicine, Hyogo, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20171207
PL  - England
TA  - Endocr Connect
JT  - Endocrine connections
JID - 101598413
PMC - PMC5776671
OTO - NOTNLM
OT  - IL-18
OT  - LADA
OT  - type 2 diabetes
EDAT- 2017/12/09 06:00
MHDA- 2017/12/09 06:01
PMCR- 2017/12/07
CRDT- 2017/12/09 06:00
PHST- 2017/11/30 00:00 [received]
PHST- 2017/12/07 00:00 [accepted]
PHST- 2017/12/09 06:00 [pubmed]
PHST- 2017/12/09 06:01 [medline]
PHST- 2017/12/09 06:00 [entrez]
PHST- 2017/12/07 00:00 [pmc-release]
AID - EC-17-0273 [pii]
AID - EC170273 [pii]
AID - 10.1530/EC-17-0273 [doi]
PST - ppublish
SO  - Endocr Connect. 2018 Jan;7(1):179-185. doi: 10.1530/EC-17-0273. Epub 2017 Dec 7.