PMID- 29218768 OWN - NLM STAT- MEDLINE DCOM- 20190403 LR - 20190403 IS - 1447-0594 (Electronic) IS - 1447-0594 (Linking) VI - 18 IP - 3 DP - 2018 Mar TI - Relationships between serum brain-derived neurotrophic factor concentration and parameters for health scores in community-dwelling older adults. PG - 456-461 LID - 10.1111/ggi.13210 [doi] AB - AIM: Brain-derived neurotrophic factor (BDNF) have been implicated in the progression of neuronal survival, phenotyping differentiation and maintenance of various neurons, as well as neurogenesis. We studied how BDNF affects health parameters of older adults by carrying out a health examination of community-dwelling older adults. METHODS: We measured the serum BDNF concentration of 898 older adults aged 65-84 years who participated in regional health examinations in the Tokyo area and also measured various parameters, such as the thickness of the quadriceps femoris, percentage of body fat, body mass index, grip strength, frequency of walking, and use of sleeping drugs and steroidal anti-inflammatory drugs. RESULTS: We obtained significant relationships between serum BDNF values and thickness of the quadriceps muscle, body mass index or percentage of body fat. Individuals holding onto something when they stood up had lower serum BDNF values than individuals not holding onto something when they stood up. Smokers had higher serum BDNF values than non-smokers. CONCLUSIONS: Older adults who had higher serum BDNF had bigger quadriceps muscles, higher body mass index and higher body fat rate, and were also able to stand up without holding onto something from a sitting position. Geriatr Gerontol Int 2018; 18: 456-461. CI - (c) 2017 Japan Geriatrics Society. FAU - Hachisu, Mitsugu AU - Hachisu M AUID- ORCID: 0000-0002-1240-1157 AD - Department of Pharmaceutical therapeutics, Division of Clinical Pharmacy, Pharmacy School, Showa University, Tokyo, Japan. FAU - Hashizume, Masahiro AU - Hashizume M AD - Department of Psychosomatic Medicine, School of Medicine, Toho University, Tokyo, Japan. FAU - Kawai, Hisashi AU - Kawai H AD - Human Care Research Team, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. FAU - Hirano, Hirohiko AU - Hirano H AD - Department of Dentistry, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. FAU - Kojima, Motonaga AU - Kojima M AD - Human Care Research Team, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. FAU - Fujiwara, Yoshinori AU - Fujiwara Y AD - Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. FAU - Obuchi, Shuichi AU - Obuchi S AD - Human Care Research Team, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. FAU - Ihara, Kazushige AU - Ihara K AD - Department of Public Health, School of Medicine, Toho University, Tokyo, Japan. LA - eng PT - Journal Article DEP - 20171208 PL - Japan TA - Geriatr Gerontol Int JT - Geriatrics & gerontology international JID - 101135738 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Aged MH - Aged, 80 and over MH - Brain-Derived Neurotrophic Factor/*blood MH - *Health Status Indicators MH - Humans MH - Independent Living MH - Tokyo OTO - NOTNLM OT - brain-derived neurotrophic factor OT - elderly cohort OT - health examination OT - quadriceps femoris EDAT- 2017/12/09 06:00 MHDA- 2019/04/04 06:00 CRDT- 2017/12/09 06:00 PHST- 2017/09/06 00:00 [revised] PHST- 2017/09/28 00:00 [accepted] PHST- 2017/12/09 06:00 [pubmed] PHST- 2019/04/04 06:00 [medline] PHST- 2017/12/09 06:00 [entrez] AID - 10.1111/ggi.13210 [doi] PST - ppublish SO - Geriatr Gerontol Int. 2018 Mar;18(3):456-461. doi: 10.1111/ggi.13210. Epub 2017 Dec 8.