PMID- 29218834
OWN - NLM
STAT- MEDLINE
DCOM- 20191108
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 18
IP  - 4
DP  - 2018 Apr
TI  - Comparative evaluation of simple indices using a single fasting blood sample to 
      estimate beta cell function after islet transplantation.
PG  - 990-997
LID - 10.1111/ajt.14620 [doi]
AB  - Six single fasting blood sample-based indices-Secretory Unit of Islet Transplant 
      Objects (SUITO), Transplant Estimated Function (TEF), Homeostasis Model 
      Assessment (HOMA)2-B%, C-peptide/glucose ratio (CP/G), C-peptide/glucose 
      creatinine ratio (CP/GCr), and BETA-2 score-were compared against commonly used 
      90-minute mixed meal tolerance test (MMTT) serum glucose and beta score to assess 
      which of them best recognizes the state of acceptable blood glucose control 
      without insulin supplementation after islet allotransplantation (ITx). We also 
      tested whether the indices could identify the success of ITx based on the Igls 
      classification of beta cell graft function. We analyzed values from 47 MMTT tests 
      in 4 patients with up to 140 months follow-up and from 54 MMTT tests in 13 
      patients with up to 42 months follow-up. SUITO, CP/G, HOMA2-B%, and BETA-2 
      correlated well with the 90-minute glucose of the MMTT and beta-score (r 
      0.54-0.76), whereas CP/GCr showed a modest performance (r 0.41-0.52) while TEF 
      showed little correlation. BETA-2 and SUITO were the best identifiers and 
      predictors of the need for insulin support, glucose intolerance, and ITx success 
      (P < .001), while HOMA2-B% and TEF were unreliable. Single fasting blood sample 
      SUITO and BETA-2 scores are very practical alternative tools that allow for 
      frequent assessments of graft function.
CI  - (c) 2017 The American Society of Transplantation and the American Society of 
      Transplant Surgeons.
FAU - Golebiewska, Justyna E
AU  - Golebiewska JE
AUID- ORCID: 0000-0001-5346-8369
AD  - Department of Surgery, University of Chicago, Chicago, IL.
AD  - Department of Nephrology, Transplantology and Internal Medicine, Medical 
      University of Gdansk, Gdansk, Poland.
FAU - Solomina, Julia
AU  - Solomina J
AD  - Department of Surgery, University of Chicago, Chicago, IL.
FAU - Thomas, Celeste
AU  - Thomas C
AD  - Department of Medicine, University of Chicago, Chicago, IL.
FAU - Kijek, Mark R
AU  - Kijek MR
AD  - Department of Surgery, University of Chicago, Chicago, IL.
FAU - Bachul, Piotr J
AU  - Bachul PJ
AD  - Department of Surgery, University of Chicago, Chicago, IL.
AD  - Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland.
FAU - Basto, Lindsay
AU  - Basto L
AD  - Department of Surgery, University of Chicago, Chicago, IL.
FAU - Golab, Karolina
AU  - Golab K
AD  - Department of Surgery, University of Chicago, Chicago, IL.
FAU - Wang, Ling-Jia
AU  - Wang LJ
AD  - Department of Surgery, University of Chicago, Chicago, IL.
FAU - Fillman, Natalie
AU  - Fillman N
AD  - Department of Surgery, University of Chicago, Chicago, IL.
FAU - Tibudan, Martin
AU  - Tibudan M
AD  - Department of Surgery, University of Chicago, Chicago, IL.
FAU - Cieply, Kamil
AU  - Cieply K
AD  - Department of Surgery, University of Chicago, Chicago, IL.
FAU - Philipson, Louis
AU  - Philipson L
AD  - Department of Medicine, University of Chicago, Chicago, IL.
FAU - Debska-Slizien, Alicja
AU  - Debska-Slizien A
AD  - Department of Nephrology, Transplantology and Internal Medicine, Medical 
      University of Gdansk, Gdansk, Poland.
FAU - Millis, J Michael
AU  - Millis JM
AD  - Department of Surgery, University of Chicago, Chicago, IL.
FAU - Fung, John
AU  - Fung J
AD  - Department of Surgery, University of Chicago, Chicago, IL.
FAU - Witkowski, Piotr
AU  - Witkowski P
AUID- ORCID: 0000-0002-4459-6673
AD  - Department of Surgery, University of Chicago, Chicago, IL.
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20180121
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Insulin)
SB  - IM
EIN - Am J Transplant. 2020 Aug;20(8):2290-2292. PMID: 32735392
MH  - Adult
MH  - Blood Glucose/analysis
MH  - C-Peptide/blood
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 1/*blood/*therapy
MH  - Fasting/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose Tolerance Test
MH  - *Graft Survival
MH  - Humans
MH  - Insulin/blood
MH  - Islets of Langerhans/*physiology
MH  - Islets of Langerhans Transplantation/*methods
MH  - Male
MH  - Middle Aged
MH  - Prognosis
OTO - NOTNLM
OT  - clinical research/practice
OT  - islet transplantation
OT  - islets of Langerhans, monitoring
OT  - physiologic
EDAT- 2017/12/09 06:00
MHDA- 2019/11/09 06:00
CRDT- 2017/12/09 06:00
PHST- 2017/09/28 00:00 [received]
PHST- 2017/11/17 00:00 [revised]
PHST- 2017/11/29 00:00 [accepted]
PHST- 2017/12/09 06:00 [pubmed]
PHST- 2019/11/09 06:00 [medline]
PHST- 2017/12/09 06:00 [entrez]
AID - S1600-6135(22)24765-0 [pii]
AID - 10.1111/ajt.14620 [doi]
PST - ppublish
SO  - Am J Transplant. 2018 Apr;18(4):990-997. doi: 10.1111/ajt.14620. Epub 2018 Jan 
      21.