PMID- 29219184
OWN - NLM
STAT- MEDLINE
DCOM- 20181120
LR  - 20220321
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 128
IP  - 6
DP  - 2018 Jun
TI  - Minimal clinically important difference of voice handicap index-10 in vocal fold 
      paralysis.
PG  - 1419-1424
LID - 10.1002/lary.27001 [doi]
AB  - OBJECTIVES/HYPOTHESIS: The Voice Handicap Index-10 (VHI-10) is commonly used to 
      measure patients' perception of vocal handicap. Clinical consensus has previously 
      defined clinically meaningful improvement as a decrease >/=5. This study determines 
      the minimal clinically important difference (MCID) for VHI-10 in patients with 
      unilateral vocal fold paralysis (UVFP) using anchor-based methodology. STUDY 
      DESIGN: Prospective cohort questionnaire analysis. METHODS: Two hundred 
      eighty-one UVFP patients completed the VHI-10 on two consecutive visits (within 3 
      months). At the follow-up visit, patients answered an 11-point Global Rating of 
      Change Questionnaire (GRCQ) scored from -5 to +5. Relationship between the GRCQ 
      and change in VHI-10 was quantified using analysis of variance, and MCID for the 
      VHI-10 was determined using receiver operating characteristic (ROC) curve 
      analysis. RESULTS: Overall mean VHI-10 change was -3.71 (standard deviation [SD] 
      = 8.89) and mean GRCQ was 1.37 (SD = 2.51). Average interval between measurements 
      was 1.73 months (SD = 0.83). Mean changes in VHI-10 scores were -7.45, -0.53, and 
      +4.40 for patients whose GRCQ scores indicated improvement, no change, and 
      worsening, respectively. Differences between mean scores were statistically 
      significant (P < .001). Area under the ROC curve was 0.80, demonstrating the 
      classification accuracy of VHI-10 change scores. A VHI-10 change of -4 was 
      determined to be the optimal threshold that discriminated between improvement and 
      no improvement (sensitivity and specificity 0.62 and 0.88, respectively). 
      CONCLUSIONS: The MCID for improvement in VHI-10 in UVFP patients is a decrease of 
      4. This information improves understanding of patients' response to treatment and 
      allows comparison between different treatments. Future research should determine 
      MCID for VHI-10 across all voice disorders. LEVEL OF EVIDENCE: 4. Laryngoscope, 
      128:1419-1424, 2018.
CI  - (c) 2017 The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Young, VyVy N
AU  - Young VN
AUID- ORCID: 0000-0002-3095-8290
AD  - Department of Otolaryngology, University of Pittsburgh Voice Center, University 
      of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
FAU - Jeong, Kwonho
AU  - Jeong K
AD  - Department of Medicine, Center for Research on Health Care Data Center, 
      University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
FAU - Rothenberger, Scott D
AU  - Rothenberger SD
AD  - Department of Medicine, Center for Research on Health Care Data Center, 
      University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
FAU - Gillespie, Amanda I
AU  - Gillespie AI
AD  - Department of Otolaryngology, University of Pittsburgh Voice Center, University 
      of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
FAU - Smith, Libby J
AU  - Smith LJ
AD  - Department of Otolaryngology, University of Pittsburgh Voice Center, University 
      of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
FAU - Gartner-Schmidt, Jackie L
AU  - Gartner-Schmidt JL
AUID- ORCID: 0000-0002-8375-462X
AD  - Department of Otolaryngology, University of Pittsburgh Voice Center, University 
      of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
FAU - Rosen, Clark A
AU  - Rosen CA
AD  - Department of Otolaryngology, University of Pittsburgh Voice Center, University 
      of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
LA  - eng
PT  - Journal Article
DEP - 20171208
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Cohort Studies
MH  - Disability Evaluation
MH  - Female
MH  - Humans
MH  - Male
MH  - Minimal Clinically Important Difference
MH  - Prospective Studies
MH  - ROC Curve
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Vocal Cord Paralysis/*diagnosis
MH  - Vocal Cords/*physiopathology
MH  - Voice
MH  - *Voice Quality
OTO - NOTNLM
OT  - Voice
OT  - measure
OT  - outcome
OT  - paralysis
EDAT- 2017/12/09 06:00
MHDA- 2018/11/21 06:00
CRDT- 2017/12/09 06:00
PHST- 2017/03/30 00:00 [received]
PHST- 2017/09/13 00:00 [revised]
PHST- 2017/10/16 00:00 [accepted]
PHST- 2017/12/09 06:00 [pubmed]
PHST- 2018/11/21 06:00 [medline]
PHST- 2017/12/09 06:00 [entrez]
AID - 10.1002/lary.27001 [doi]
PST - ppublish
SO  - Laryngoscope. 2018 Jun;128(6):1419-1424. doi: 10.1002/lary.27001. Epub 2017 Dec 
      8.