PMID- 29220212
OWN - NLM
STAT- MEDLINE
DCOM- 20181106
LR  - 20181106
IS  - 1546-3141 (Electronic)
IS  - 0361-803X (Linking)
VI  - 210
IP  - 2
DP  - 2018 Feb
TI  - Comparison of Xenon-Enhanced Area-Detector CT and Krypton Ventilation SPECT/CT 
      for Assessment of Pulmonary Functional Loss and Disease Severity in Smokers.
PG  - W45-W53
LID - 10.2214/AJR.17.18709 [doi]
AB  - OBJECTIVE: The objective of this study was to compare the capability of 
      xenon-enhanced area-detector CT (ADCT) performed with a subtraction technique and 
      coregistered (81m)Kr-ventilation SPECT/CT for the assessment of pulmonary 
      functional loss and disease severity in smokers. SUBJECTS AND METHODS: Forty-six 
      consecutive smokers (32 men and 14 women; mean age, 67.0 years) underwent 
      prospective unenhanced and xenon-enhanced ADCT, (81m)Kr-ventilation SPECT/CT, and 
      pulmonary function tests. Disease severity was evaluated according to the Global 
      Initiative for Chronic Obstructive Lung Disease (GOLD) classification. CT-based 
      functional lung volume (FLV), the percentage of wall area to total airway area 
      (WA%), and ventilated FLV on xenon-enhanced ADCT and SPECT/CT were calculated for 
      each smoker. All indexes were correlated with percentage of forced expiratory 
      volume in 1 second (%FEV(1)) using step-wise regression analyses, and univariate 
      and multivariate logistic regression analyses were performed. In addition, the 
      diagnostic accuracy of the proposed model was compared with that of each 
      radiologic index by means of McNemar analysis. RESULTS: Multivariate logistic 
      regression showed that %FEV(1) was significantly affected (r = 0.77, r(2) = 0.59) 
      by two factors: the first factor, ventilated FLV on xenon-enhanced ADCT (p < 
      0.0001); and the second factor, WA% (p = 0.004). Univariate logistic regression 
      analyses indicated that all indexes significantly affected GOLD classification (p 
      < 0.05). Multivariate logistic regression analyses revealed that ventilated FLV 
      on xenon-enhanced ADCT and CT-based FLV significantly influenced GOLD 
      classification (p < 0.0001). The diagnostic accuracy of the proposed model was 
      significantly higher than that of ventilated FLV on SPECT/CT (p = 0.03) and WA% 
      (p = 0.008). CONCLUSION: Xenon-enhanced ADCT is more effective than 
      (81m)Kr-ventilation SPECT/CT for the assessment of pulmonary functional loss and 
      disease severity.
FAU - Ohno, Yoshiharu
AU  - Ohno Y
AD  - 1 Department of Radiology, Division of Functional and Diagnostic Imaging 
      Research, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, 
      Chuo-ku, Kobe, Hyogo 650-0017, Japan.
AD  - 2 Advanced Biomedical Imaging Research Center, Kobe University Graduate School of 
      Medicine, Kobe, Japan.
FAU - Fujisawa, Yasuko
AU  - Fujisawa Y
AD  - 3 Toshiba Medical Systems Corporation, Otawara, Japan.
FAU - Takenaka, Daisuke
AU  - Takenaka D
AD  - 4 Department of Radiology, Hyogo Cancer Center, Akashi, Japan.
FAU - Kaminaga, Shigeo
AU  - Kaminaga S
AD  - 3 Toshiba Medical Systems Corporation, Otawara, Japan.
FAU - Seki, Shinichiro
AU  - Seki S
AD  - 1 Department of Radiology, Division of Functional and Diagnostic Imaging 
      Research, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, 
      Chuo-ku, Kobe, Hyogo 650-0017, Japan.
AD  - 2 Advanced Biomedical Imaging Research Center, Kobe University Graduate School of 
      Medicine, Kobe, Japan.
FAU - Sugihara, Naoki
AU  - Sugihara N
AD  - 3 Toshiba Medical Systems Corporation, Otawara, Japan.
FAU - Yoshikawa, Takeshi
AU  - Yoshikawa T
AD  - 1 Department of Radiology, Division of Functional and Diagnostic Imaging 
      Research, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, 
      Chuo-ku, Kobe, Hyogo 650-0017, Japan.
AD  - 2 Advanced Biomedical Imaging Research Center, Kobe University Graduate School of 
      Medicine, Kobe, Japan.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20171208
PL  - United States
TA  - AJR Am J Roentgenol
JT  - AJR. American journal of roentgenology
JID - 7708173
RN  - 3H3U766W84 (Xenon)
RN  - 5I8I620HVX (Krypton)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Krypton
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Pulmonary Disease, Chronic Obstructive/*diagnostic imaging/*physiopathology
MH  - Respiratory Function Tests
MH  - Severity of Illness Index
MH  - *Single Photon Emission Computed Tomography Computed Tomography
MH  - *Smokers
MH  - Xenon
OTO - NOTNLM
OT  - CT
OT  - chronic obstructive pulmonary disease (COPD)
OT  - lung
OT  - ventilation
OT  - xenon
EDAT- 2017/12/09 06:00
MHDA- 2018/11/07 06:00
CRDT- 2017/12/09 06:00
PHST- 2017/12/09 06:00 [pubmed]
PHST- 2018/11/07 06:00 [medline]
PHST- 2017/12/09 06:00 [entrez]
AID - 10.2214/AJR.17.18709 [doi]
PST - ppublish
SO  - AJR Am J Roentgenol. 2018 Feb;210(2):W45-W53. doi: 10.2214/AJR.17.18709. Epub 
      2017 Dec 8.