PMID- 29221293
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 9
IP  - 9
DP  - 2017 Sep
TI  - Distance-saturation product of the 6-minute walk test predicts mortality of 
      patients with non-cystic fibrosis bronchiectasis.
PG  - 3168-3176
LID - 10.21037/jtd.2017.08.53 [doi]
AB  - BACKGROUND: Previous surveillance methods to monitor the prognoses of patients 
      with bronchiectasis are too complex for use in daily practice. The 6-minute walk 
      test (6MWT) is a simple exercise test to predict the prognosis of chronic 
      obstructive airway disease and numerous chronic lung diseases, including 
      idiopathic pulmonary fibrosis. No studies have investigated exercise-induced 
      oxygen desaturation (EID) and distance-saturation product (DSP) of 6MWT to 
      predict the prognoses of patients with bronchiectasis. METHODS: This was a 
      prospective study to identify correlations between variables of 6MWT and 
      mortality in patients with bronchiectasis over a 6-year period. The study cohort 
      included 69 patients with stable non-cystic fibrosis (non-CF) bronchiectasis who 
      were regularly evaluated for functional status via 6-minute walk distance (6MWD), 
      spirometry, BODE index, EID, and DSP. RESULTS: Of the 69 patients, 9 (13%) died 
      and 60 (87%) survived during the 6-year follow-up period. The percentage of EID 
      was higher [7 of 9 patients (78%) vs. 22 of 60 patients (27%), P=0.003] in the 
      non-survivors group. The 6MWD (467.9+/-77.1 vs. 363.7+/-126.7 m, P=0.001) was higher 
      in the survivors group. DSP was significantly lower in the non-survivors group 
      (411.0+/-78.4 vs. 283.9+/-90.0 m%, P<0.001). Multivariate analysis showed that DSP 
      (OR =0.983; 95% CI: 0.974-0.993, P=0.001) was the best parameter of 6MWT to 
      predict mortality. Patients with a lower DSP of <280 m% were at a 66.5-fold 
      greater risk (OR =66.5; 95% CI: 9.4-469.2) of 6-year mortality compared with 
      those with DSP >280 m% (P<0.001). CONCLUSIONS: DSP is a simple parameter to 
      predict 6-year mortality in patients with non-CF bronchiectasis.
FAU - Hsieh, Meng-Heng
AU  - Hsieh MH
AD  - Department of Thoracic Medicine, Chang Gung Medical Foundation, Chang Gung 
      University, College of Medicine, Taoyuan, Taiwan.
FAU - Fang, Yueh-Fu
AU  - Fang YF
AD  - Department of Thoracic Medicine, Chang Gung Medical Foundation, Chang Gung 
      University, College of Medicine, Taoyuan, Taiwan.
FAU - Chung, Fu-Tsai
AU  - Chung FT
AD  - Department of Thoracic Medicine, Chang Gung Medical Foundation, Chang Gung 
      University, College of Medicine, Taoyuan, Taiwan.
FAU - Lee, Chung-Shu
AU  - Lee CS
AD  - Department of Thoracic Medicine, Chang Gung Medical Foundation, Chang Gung 
      University, College of Medicine, Taoyuan, Taiwan.
FAU - Chang, Yu-Chen
AU  - Chang YC
AD  - Department of Nuclear Medicine, Chang Gung Medical Foundation, Chang Gung 
      University, College of Medicine, Taoyuan, Taiwan.
FAU - Liu, Yuan-Zhang
AU  - Liu YZ
AD  - Department of Radiology, Chang Gung Medical Foundation, Chang Gung University, 
      College of Medicine, Taoyuan, Taiwan.
FAU - Wu, Cheng-Hsien
AU  - Wu CH
AD  - Department of Radiology, Chang Gung Medical Foundation, Chang Gung University, 
      College of Medicine, Taoyuan, Taiwan.
FAU - Lin, Horng-Chyuan
AU  - Lin HC
AD  - Department of Thoracic Medicine, Chang Gung Medical Foundation, Chang Gung 
      University, College of Medicine, Taoyuan, Taiwan.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC5708370
OTO - NOTNLM
OT  - 6-minute walk test (6MWT)
OT  - Non-cystic fibrosis (non-CF) bronchiectasis
OT  - distance-saturation product (DSP)
OT  - mortality
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2017/12/10 06:00
MHDA- 2017/12/10 06:01
PMCR- 2017/09/01
CRDT- 2017/12/10 06:00
PHST- 2017/12/10 06:00 [entrez]
PHST- 2017/12/10 06:00 [pubmed]
PHST- 2017/12/10 06:01 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - jtd-09-09-3168 [pii]
AID - 10.21037/jtd.2017.08.53 [doi]
PST - ppublish
SO  - J Thorac Dis. 2017 Sep;9(9):3168-3176. doi: 10.21037/jtd.2017.08.53.