PMID- 29223148
OWN - NLM
STAT- MEDLINE
DCOM- 20200512
LR  - 20200512
IS  - 0125-877X (Print)
IS  - 0125-877X (Linking)
VI  - 36
IP  - 3
DP  - 2018 Sep
TI  - Exhaled nitric oxide helps discriminating asthmatic children with and without 
      positive specific IgE to aeroallergens.
PG  - 145-151
LID - 10.12932/AP-270717-0126 [doi]
AB  - BACKGROUND: Aeroallergen sensitization may predict higher fractional exhaled 
      nitric oxide (FeNO) levels. OBJECTIVE: We evaluate cut-off values of FeNO in 
      asthmatic children with and without positive specific immunoglobulin E (IgE) to 
      at least one of 5 aeroallergens (Dermatophagoides pteronyssinus, Dermatophagoides 
      farinae, cat, dog, and cockroach). METHODS: 564 patients with asthma and allergic 
      rhinitis (AR) aged 5 to 18 years were enrolled into two groups. Sensitized group 
      included 378 children with positive IgE to at least one of 5 inhaled allergens. 
      Non-sensitized group included 186 children. Pulmonary function tests, FeNO, 
      eosinophil counts, and IgE levels were examined. Patients were divided into 
      preschool age (5~6 years old), elementary school children (7~11 years old) and 
      adolescents (12~18 years old). RESULTS: In preschool children, FeNO>/=15.5 ppb 
      differentiates between non-sensitized and sensitized groups. (sensitivity 54.3%; 
      specificity 87.5%; positive predictive value (PPV) 86.2%; negative predictive 
      value (NPV) 57.1%; area under receiver operating characteristic curve (AUC) 0.72) 
      Among elementary school children, the cut-off value of FeNO>/=19.5 ppb showed 
      sensitivity 66.4%; specificity 85.8%; PPV 90.5%; NPV 55.7%; AUC 0.81. In 
      adolescents, FeNO>/=27.5 ppb showed sensitivity 60.2%; specificity 85.4%; PPV 
      91.2%; NPV 46.1%; AUC 0.76. CONCLUSION: In asthmatic children, aeroallergen 
      sensitization appears to contribute to higher FeNO levels than those not 
      sensitized. Cut-off values of FeNO which well discriminate asthmatic children 
      with and without aeroallergen sensitization should be chose according to 
      different ages.
FAU - Fang, Li-Ching
AU  - Fang LC
AD  - Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
FAU - Shyur, Shyh-Dar
AU  - Shyur SD
AD  - Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
AD  - School of Medicine, Mackay Medical College, New Taipei City, Taiwan.
FAU - Wang, Jen-Yu
AU  - Wang JY
AD  - Department of Dermatology, Mackay memorial hospital, Taipei,Taiwan.
FAU - Kao, Yu-Hsuan
AU  - Kao YH
AD  - Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
FAU - Yang, Chien-Hui
AU  - Yang CH
AD  - Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
FAU - Yu, Yu-Ting
AU  - Yu YT
AD  - Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Allergy Immunol
JT  - Asian Pacific journal of allergy and immunology
JID - 8402034
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Insect Proteins)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/immunology
MH  - Animals
MH  - Antigens, Dermatophagoides/immunology
MH  - Asthma/*diagnosis/*immunology
MH  - Cats
MH  - Child
MH  - Child, Preschool
MH  - Dogs
MH  - Exhalation
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*diagnosis/*immunology
MH  - Immunoglobulin E/immunology
MH  - Insect Proteins/immunology
MH  - Male
MH  - Nitric Oxide/*analysis
MH  - Respiratory Function Tests/methods
MH  - Retrospective Studies
EDAT- 2017/12/11 06:00
MHDA- 2020/05/13 06:00
CRDT- 2017/12/11 06:00
PHST- 2017/12/11 06:00 [pubmed]
PHST- 2020/05/13 06:00 [medline]
PHST- 2017/12/11 06:00 [entrez]
AID - 10.12932/AP-270717-0126 [doi]
PST - ppublish
SO  - Asian Pac J Allergy Immunol. 2018 Sep;36(3):145-151. doi: 
      10.12932/AP-270717-0126.