PMID- 29223787
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20180507
IS  - 1096-0341 (Electronic)
IS  - 0042-6822 (Linking)
VI  - 515
DP  - 2018 Feb
TI  - A novel peptide-based vaccine candidate with protective efficacy against 
      influenza A in a mouse model.
PG  - 21-28
LID - S0042-6822(17)30397-5 [pii]
LID - 10.1016/j.virol.2017.11.018 [doi]
AB  - Current influenza vaccines mainly induce antibody responses to the variable 
      hemagglutinin proteins of the virus strains included in the vaccine. Instead, a 
      broadly protective influenza vaccine should aim at inducing antibody- and/or 
      cell-mediated immunity against conserved viral proteins. Vacc-FLU is a peptide 
      based vaccine combining conserved B and T cell epitopes. Peptide selection was 
      done using a proprietary peptide design platform technology focusing on responses 
      to human leukocyte antigen (HLA)-restricted epitopes. Immunization of wild-type 
      mice and mice transgenic for HLA-A2.1 with the peptide mix successfully induced 
      both humoral and cell mediated immune responses. Partial protection from severe 
      weight loss upon challenge was observed in both mouse strains but was stronger 
      and observed at lower vaccine doses in transgenic mice. Our results show that the 
      Vacc-FLU peptide mix is capable of inducing IFNgamma-producing T cells and 
      antibody-producing B cells which can protect from severe disease symptoms upon 
      infection.
CI  - Copyright (c) 2017 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Herrera-Rodriguez, Jose
AU  - Herrera-Rodriguez J
AD  - Department of Medical Microbiology, University of Groningen, University Medical 
      Center Groningen, Groningen, The Netherlands.
FAU - Meijerhof, Tjarko
AU  - Meijerhof T
AD  - Department of Medical Microbiology, University of Groningen, University Medical 
      Center Groningen, Groningen, The Netherlands.
FAU - Niesters, Hubert G
AU  - Niesters HG
AD  - Department of Medical Microbiology, University of Groningen, University Medical 
      Center Groningen, Groningen, The Netherlands.
FAU - Stjernholm, Grete
AU  - Stjernholm G
AD  - Bionor Pharma AS, P.O. Box 1477 Vika, NO-0116 Oslo, Norway.
FAU - Hovden, Arnt-Ove
AU  - Hovden AO
AD  - Bionor Pharma AS, P.O. Box 1477 Vika, NO-0116 Oslo, Norway.
FAU - Sorensen, Birger
AU  - Sorensen B
AD  - Department of Medical Microbiology, University of Groningen, University Medical 
      Center Groningen, Groningen, The Netherlands; Bionor Pharma AS, P.O. Box 1477 
      Vika, NO-0116 Oslo, Norway.
FAU - Okvist, Mats
AU  - Okvist M
AD  - Bionor Pharma AS, P.O. Box 1477 Vika, NO-0116 Oslo, Norway.
FAU - Sommerfelt, Maja A
AU  - Sommerfelt MA
AD  - Bionor Pharma AS, P.O. Box 1477 Vika, NO-0116 Oslo, Norway.
FAU - Huckriede, Anke
AU  - Huckriede A
AD  - Department of Medical Microbiology, University of Groningen, University Medical 
      Center Groningen, Groningen, The Netherlands. Electronic address: 
      a.l.w.huckriede@umcg.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171207
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (Influenza Vaccines)
RN  - 0 (Peptides)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Epitopes, T-Lymphocyte/immunology
MH  - Female
MH  - HLA-A2 Antigen
MH  - Humans
MH  - *Immunity, Cellular
MH  - *Immunity, Humoral
MH  - Immunization
MH  - Influenza A virus/*immunology
MH  - Influenza Vaccines/*immunology
MH  - Influenza, Human/*prevention & control/virology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Peptides/*immunology
MH  - Random Allocation
OTO - NOTNLM
OT  - Cell mediated immunity
OT  - Humoral immunity
OT  - Influenza
OT  - Peptides
OT  - Universal vaccine
EDAT- 2017/12/11 06:00
MHDA- 2018/05/08 06:00
CRDT- 2017/12/11 06:00
PHST- 2017/09/25 00:00 [received]
PHST- 2017/11/10 00:00 [revised]
PHST- 2017/11/21 00:00 [accepted]
PHST- 2017/12/11 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2017/12/11 06:00 [entrez]
AID - S0042-6822(17)30397-5 [pii]
AID - 10.1016/j.virol.2017.11.018 [doi]
PST - ppublish
SO  - Virology. 2018 Feb;515:21-28. doi: 10.1016/j.virol.2017.11.018. Epub 2017 Dec 7.